SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vkg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 PHE A3920
LEU A3924
ALA A3801
LEU A3798
ILE A3974
 None
 1.02A 1crbA-3vkgA:
undetectable		 1crbA-3vkgA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 ALA A2109
PHE A2132
SER A2198
ILE A2199
LEU A2219
 None
 1.07A 1dlsA-3vkgA:
undetectable		 1dlsA-3vkgA:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 ALA A2109
PHE A2132
SER A2198
ILE A2199
LEU A2219
 None
 0.99A 1drfA-3vkgA:
undetectable		 1drfA-3vkgA:
4.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 SER A4687
VAL A4688
MET A4642
VAL A4639
 None
 1.07A 1fduB-3vkgA:
undetectable		 1fduB-3vkgA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 LEU A4229
LEU A4230
SER A4233
LEU A4187
ILE A4190
 None
 1.37A 1fmlA-3vkgA:
undetectable		 1fmlA-3vkgA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 4 LEU A1543
PRO A1654
LEU A1545
ARG A1556
 None
 1.36A 1hrkB-3vkgA:
undetectable		 1hrkB-3vkgA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 GLU A1567
HIS A1568
ASP A3053
 None
 0.76A 1i9gA-3vkgA:
undetectable		 1i9gA-3vkgA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 4 GLY A1992
LEU A1991
GLY A1937
ARG A1993
 None
 0.96A 1j7kA-3vkgA:
undetectable		 1j7kA-3vkgA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 7 LEU A2431
VAL A2512
TYR A2505
TYR A2430
 None
 0.89A 1lweA-3vkgA:
undetectable		 1lweA-3vkgA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 ASP A2399
GLY A2276
ASP A2307
ASP A2358
 None
 0.84A 1m4iA-3vkgA:
undetectable		 1m4iA-3vkgA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 THR A2251
GLU A2257
ASP A2201
 None
 0.86A 1nt2A-3vkgA:
undetectable		 1nt2A-3vkgA:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 THR A1953
ASP A1954
ILE A1927
PHE A1934
TYR A1936
 ADP  A9001 (-4.0A)
None
None
None
None
 1.11A 1oltA-3vkgA:
undetectable		 1oltA-3vkgA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 10 LEU A3959
ALA A3915
LEU A3971
GLN A3970
GLN A3910
 None
 1.22A 1rlbE-3vkgA:
undetectable		 1rlbE-3vkgA:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 5 TYR A1803
LEU A1878
VAL A1815
VAL A1822
 None
 1.22A 1t88B-3vkgA:
undetectable		 1t88B-3vkgA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 VAL A1888
VAL A1883
TRP A1823
 None
 0.96A 1w5uC-3vkgA:
undetectable
1w5uD-3vkgA:
undetectable		 1w5uC-3vkgA:
1.24
1w5uD-3vkgA:
1.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 7 PHE A3763
PHE A3786
LEU A3652
PHE A3765
 None
 1.12A 1wrlE-3vkgA:
undetectable		 1wrlE-3vkgA:
2.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 TYR A3601
LEU A3181
TYR A3233
THR A3237
ILE A3238
 None
 1.48A 1xoqA-3vkgA:
undetectable		 1xoqA-3vkgA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 TYR A3601
LEU A3181
TYR A3233
THR A3237
ILE A3238
 None
 1.48A 1xoqB-3vkgA:
undetectable		 1xoqB-3vkgA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 4 LEU A3943
SER A3944
TYR A3942
LEU A3930
 None
 1.28A 1xz1A-3vkgA:
undetectable		 1xz1A-3vkgA:
4.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 4 LEU A3943
SER A3944
TYR A3942
LEU A3930
 None
 1.29A 1xz3A-3vkgA:
undetectable		 1xz3A-3vkgA:
4.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 ARG A3767
SER A3912
LEU A4133
LEU A4204
 None
 0.93A 2bfpA-3vkgA:
undetectable		 2bfpA-3vkgA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 PHE A2538
TYR A2430
LEU A2577
LEU A2581
 None
 0.95A 2bfpA-3vkgA:
undetectable		 2bfpA-3vkgA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 ARG A3767
SER A3912
LEU A4133
LEU A4204
 None
 0.95A 2bfpB-3vkgA:
undetectable		 2bfpB-3vkgA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 PHE A2538
TYR A2430
LEU A2577
LEU A2581
 None
 0.96A 2bfpB-3vkgA:
undetectable		 2bfpB-3vkgA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 ARG A3767
SER A3912
LEU A4133
LEU A4204
 None
 0.93A 2bfpD-3vkgA:
undetectable		 2bfpD-3vkgA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 5 GLY A3020
LYS A3022
LEU A3014
PRO A3149
 ADP  A9004 (-3.6A)
ADP  A9004 (-3.4A)
None
None
 1.31A 2dqyA-3vkgA:
undetectable		 2dqyA-3vkgA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 PHE A2701
VAL A2759
ILE A2786
CYH A2718
LEU A2699
 None
 1.22A 2ft9A-3vkgA:
undetectable		 2ft9A-3vkgA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 ILE A2243
ALA A2244
THR A2284
VAL A2288
ARG A2530
 None
None
ADP  A9002 (-3.1A)
None
None
 1.12A 2g78A-3vkgA:
undetectable		 2g78A-3vkgA:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 4 LEU A1543
PRO A1654
LEU A1545
ARG A1556
 None
 1.37A 2hrcB-3vkgA:
undetectable		 2hrcB-3vkgA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 4 LEU A2434
ILE A2569
ILE A2501
ALA A2500
 None
 0.84A 2i30A-3vkgA:
undetectable		 2i30A-3vkgA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 VAL A1883
TRP A1823
VAL A1888
 None
 0.94A 2izqA-3vkgA:
undetectable
2izqB-3vkgA:
undetectable		 2izqA-3vkgA:
1.24
2izqB-3vkgA:
1.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 6 GLY A1743
PHE A1754
PRO A1757
THR A1740
 None
 1.35A 2m2oB-3vkgA:
undetectable		 2m2oB-3vkgA:
1.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 5 SER A2097
GLY A4345
ASP A4311
ASP A4302
 None
 1.12A 2oxtB-3vkgA:
undetectable		 2oxtB-3vkgA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 SER A3842
ASP A3301
ASP A3294
 None
 0.64A 2plwA-3vkgA:
undetectable		 2plwA-3vkgA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 4 LEU A1543
PRO A1654
LEU A1545
ARG A1556
 None
 1.41A 2pnjB-3vkgA:
undetectable		 2pnjB-3vkgA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 7 LEU A1729
LEU A1770
ILE A1758
MET A1744
 None
 1.07A 2qqcG-3vkgA:
undetectable
2qqcJ-3vkgA:
undetectable		 2qqcG-3vkgA:
2.22
2qqcJ-3vkgA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 7 LEU A1729
LEU A1770
ILE A1758
MET A1744
 None
 1.07A 2qqdA-3vkgA:
undetectable
2qqdE-3vkgA:
undetectable		 2qqdA-3vkgA:
2.26
2qqdE-3vkgA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 LYS A3964
ARG A3957
VAL A3955
 None
 0.97A 2r2vC-3vkgA:
undetectable
2r2vD-3vkgA:
undetectable		 2r2vC-3vkgA:
1.09
2r2vD-3vkgA:
1.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 10 GLN A1813
LEU A1814
LEU A1817
LEU A1925
LEU A1785
 None
 0.92A 2riwA-3vkgA:
undetectable
2riwB-3vkgA:
undetectable		 2riwA-3vkgA:
7.50
2riwB-3vkgA:
1.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_A_BEZA1222_0
(PEROXIREDOXIN 6.)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 9 PRO A3775
THR A3256
VAL A3017
SER A3018
ALA A3150
 None
 1.41A 2v41A-3vkgA:
undetectable
2v41B-3vkgA:
undetectable		 2v41A-3vkgA:
5.36
2v41B-3vkgA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 7 PHE A2593
LEU A2516
ALA A2519
PHE A2528
 None
 0.59A 2vcvA-3vkgA:
undetectable		 2vcvA-3vkgA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 7 PHE A2593
LEU A2516
ALA A2519
PHE A2528
 None
 0.66A 2vcvG-3vkgA:
undetectable		 2vcvG-3vkgA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 7 PHE A2593
LEU A2516
ALA A2519
PHE A2528
 None
 0.50A 2vcvL-3vkgA:
undetectable		 2vcvL-3vkgA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 PHE A2593
LEU A2516
ALA A2519
PHE A2528
 None
 0.69A 2vcvP-3vkgA:
undetectable		 2vcvP-3vkgA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 PHE A1904
SER A4340
LEU A4338
 None
 0.82A 2w1bA-3vkgA:
undetectable		 2w1bA-3vkgA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 LEU A2711
ILE A2786
PHE A2788
PHE A2772
 None
 0.91A 2weyB-3vkgA:
undetectable		 2weyB-3vkgA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 10 GLN A1813
LEU A1814
LEU A1817
LEU A1925
LEU A1785
 None
 1.05A 2xn6A-3vkgA:
undetectable
2xn6B-3vkgA:
undetectable		 2xn6A-3vkgA:
7.75
2xn6B-3vkgA:
1.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 10 GLN A1813
LEU A1814
LEU A1817
LEU A1925
LEU A1785
 None
 1.04A 2xn7A-3vkgA:
undetectable
2xn7B-3vkgA:
undetectable		 2xn7A-3vkgA:
7.81
2xn7B-3vkgA:
1.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 SER A4010
GLN A4017
ILE A4005
SER A4041
 None
 1.14A 2xz5B-3vkgA:
undetectable
2xz5E-3vkgA:
undetectable		 2xz5B-3vkgA:
5.52
2xz5E-3vkgA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 5 ILE A2827
ARG A2877
MET A2682
THR A2681
 ADP  A9003 (-3.8A)
None
ADP  A9003 (-3.4A)
ADP  A9003 (-3.5A)
 1.48A 3abkN-3vkgA:
undetectable
3abkW-3vkgA:
undetectable		 3abkN-3vkgA:
9.59
3abkW-3vkgA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 HIS A2270
LEU A2266
PHE A2395
LEU A2367
LEU A2387
 None
 1.35A 3adsA-3vkgA:
undetectable		 3adsA-3vkgA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 ALA A2642
PHE A2913
ASN A2832
GLY A2829
LEU A2849
 None
 1.13A 3aodC-3vkgA:
undetectable		 3aodC-3vkgA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 6 ASP A3074
LEU A3014
LEU A3091
HIS A3011
 None
 1.24A 3bj8C-3vkgA:
undetectable
3bj8D-3vkgA:
undetectable		 3bj8C-3vkgA:
4.18
3bj8D-3vkgA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 11 LEU A1991
ALA A1932
ALA A1930
MET A1910
TYR A1957
 None
 1.34A 3bszF-3vkgA:
undetectable		 3bszF-3vkgA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 4 VAL A3267
ARG A3620
ILE A3238
THR A3189
 None
 0.95A 3cl9A-3vkgA:
undetectable		 3cl9A-3vkgA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 TYR A3601
LEU A3181
TYR A3233
THR A3237
ILE A3238
 None
 1.48A 3g4lC-3vkgA:
undetectable		 3g4lC-3vkgA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 ASP A4352
LEU A4644
PRO A4289
GLY A4291
LEU A4290
 None
 1.32A 3j6pB-3vkgA:
undetectable		 3j6pB-3vkgA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 ALA A2109
PHE A2132
SER A2198
ILE A2199
LEU A2219
 None
 1.12A 3k2hB-3vkgA:
undetectable		 3k2hB-3vkgA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 LEU A2910
ASP A2996
ARG A2911
ALA A3180
GLU A3179
 None
 1.24A 3k39C-3vkgA:
undetectable		 3k39C-3vkgA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 LEU A2910
ASP A2996
ARG A2911
ALA A3180
GLU A3179
 None
 1.24A 3k39D-3vkgA:
undetectable		 3k39D-3vkgA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 LEU A2910
ASP A2996
ARG A2911
ALA A3180
GLU A3179
 None
 1.25A 3k39I-3vkgA:
undetectable		 3k39I-3vkgA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 LEU A2910
ASP A2996
ARG A2911
ALA A3180
GLU A3179
 None
 1.23A 3k39J-3vkgA:
undetectable		 3k39J-3vkgA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 LEU A2910
ASP A2996
ARG A2911
ALA A3180
GLU A3179
 None
 1.23A 3k39K-3vkgA:
undetectable		 3k39K-3vkgA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 LEU A2910
ASP A2996
ARG A2911
ALA A3180
GLU A3179
 None
 1.23A 3k39L-3vkgA:
undetectable		 3k39L-3vkgA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 PHE A1537
LEU A1602
ILE A1656
LEU A1543
ASP A1544
 None
 1.19A 3ko0G-3vkgA:
undetectable
3ko0H-3vkgA:
undetectable
3ko0I-3vkgA:
undetectable
3ko0J-3vkgA:
undetectable		 3ko0G-3vkgA:
2.97
3ko0H-3vkgA:
2.97
3ko0I-3vkgA:
2.97
3ko0J-3vkgA:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 ILE A2046
THR A2045
VAL A2057
SER A2010
VAL A2014
 None
 1.05A 3kpdC-3vkgA:
undetectable		 3kpdC-3vkgA:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 GLY A2072
ALA A2021
GLY A2020
LEU A2067
ILE A2046
 None
 0.92A 3ku1A-3vkgA:
undetectable		 3ku1A-3vkgA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 GLY A2072
ALA A2021
GLY A2020
LEU A2067
ILE A2046
 None
 0.94A 3ku1C-3vkgA:
undetectable		 3ku1C-3vkgA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 GLY A2072
ALA A2021
GLY A2020
LEU A2067
ILE A2046
 None
 0.99A 3ku1G-3vkgA:
undetectable		 3ku1G-3vkgA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 VAL A1888
VAL A1883
TRP A1823
 None
 0.90A 3l8lC-3vkgA:
undetectable
3l8lD-3vkgA:
undetectable		 3l8lC-3vkgA:
1.24
3l8lD-3vkgA:
1.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 ALA A4193
LEU A4200
LEU A4197
ALA A4171
ILE A4162
 None
 1.10A 3lbdA-3vkgA:
undetectable		 3lbdA-3vkgA:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 VAL A2641
GLY A2829
ALA A2834
LEU A2835
LEU A2879
 None
 0.99A 3mb5A-3vkgA:
undetectable		 3mb5A-3vkgA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 VAL A1815
SER A1819
LEU A1878
 None
 0.69A 3n8xA-3vkgA:
undetectable		 3n8xA-3vkgA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 GLN A1885
LEU A1859
LEU A1856
ILE A1879
 None
 0.90A 3nbqB-3vkgA:
undetectable		 3nbqB-3vkgA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 5 LEU A4290
SER A4720
LEU A4410
PRO A4411
 None
 1.23A 3onnA-3vkgA:
undetectable		 3onnA-3vkgA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 9 ILE A3845
ALA A3562
LEU A3563
LEU A3838
ALA A3841
 None
 0.89A 3ozvB-3vkgA:
undetectable		 3ozvB-3vkgA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 GLU A4297
PHE A4295
GLN A4282
 None
 0.96A 3r55A-3vkgA:
undetectable		 3r55A-3vkgA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 HIS A2524
ILE A2525
ILE A2671
ARG A2532
 None
 1.06A 3sfeB-3vkgA:
undetectable
3sfeC-3vkgA:
undetectable		 3sfeB-3vkgA:
5.46
3sfeC-3vkgA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 VAL A4688
LEU A4705
LEU A4654
ILE A4664
 None
 0.89A 3u5kA-3vkgA:
undetectable		 3u5kA-3vkgA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 VAL A4688
LEU A4705
LEU A4654
ILE A4664
 None
 0.90A 3u5kC-3vkgA:
undetectable		 3u5kC-3vkgA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 9 ASP A2201
GLY A2193
ILE A2192
LEU A2156
VAL A2155
 None
 1.04A 3u7sB-3vkgA:
undetectable		 3u7sB-3vkgA:
2.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 5 TYR A1957
SER A1989
ASP A2104
ILE A2108
 None
None
None
ADP  A9001 (-4.3A)
 1.25A 3uj7B-3vkgA:
undetectable		 3uj7B-3vkgA:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 ILE A1927
TYR A1912
LEU A1925
LEU A1814
TYR A1957
 None
 1.31A 3vn2A-3vkgA:
undetectable		 3vn2A-3vkgA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 LEU A2087
PRO A2088
LEU A2091
 None
 0.45A 3w1wB-3vkgA:
undetectable		 3w1wB-3vkgA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 TYR A3601
TRP A3617
ARG A3620
LEU A3621
 None
 0.93A 3wipG-3vkgA:
undetectable
3wipH-3vkgA:
undetectable		 3wipG-3vkgA:
5.57
3wipH-3vkgA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 ARG A3620
LEU A3621
TYR A3601
TRP A3617
 None
 0.95A 3wipF-3vkgA:
undetectable
3wipJ-3vkgA:
undetectable		 3wipF-3vkgA:
5.57
3wipJ-3vkgA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 ILE A1718
ASN A1711
GLY A1710
ILE A1709
 None
 0.75A 3wxoA-3vkgA:
undetectable		 3wxoA-3vkgA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 LEU A4248
LEU A4375
ILE A4280
GLN A4362
PHE A4373
 None
 1.21A 4a79B-3vkgA:
undetectable		 4a79B-3vkgA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 5 VAL A4688
LEU A4705
LEU A4654
ILE A4664
 None
 0.95A 4a9jB-3vkgA:
undetectable		 4a9jB-3vkgA:
3.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 5 VAL A4688
LEU A4705
LEU A4654
ILE A4664
 None
 0.94A 4a9jC-3vkgA:
undetectable		 4a9jC-3vkgA:
3.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 TYR A1548
CYH A1552
ILE A1646
ILE A1644
 None
 1.03A 4afgD-3vkgA:
undetectable
4afgE-3vkgA:
undetectable		 4afgD-3vkgA:
5.56
4afgE-3vkgA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 7 LEU A2431
VAL A2512
TYR A2505
TYR A2430
 None
 1.07A 4b3qA-3vkgA:
undetectable		 4b3qA-3vkgA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 LEU A1831
TRP A1906
ARG A1911
VAL A1827
 None
 0.97A 4em2A-3vkgA:
undetectable		 4em2A-3vkgA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 11 LEU A2511
VAL A2512
ALA A2519
PHE A2593
PHE A2596
 None
 1.44A 4evrA-3vkgA:
undetectable		 4evrA-3vkgA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 ASN A3661
PHE A3786
VAL A3674
LEU A3652
 None
 1.09A 4f5zA-3vkgA:
undetectable		 4f5zA-3vkgA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 5 LEU A1867
ARG A1872
ILE A1879
ASN A1857
 None
 1.10A 4i00A-3vkgA:
undetectable		 4i00A-3vkgA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 7 THR A4015
LYS A4082
GLN A4066
LEU A4033
 None
 1.03A 4ib4A-3vkgA:
undetectable		 4ib4A-3vkgA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 PRO A2707
GLN A2765
ILE A2311
MET A2766
 None
 1.10A 4iilA-3vkgA:
undetectable		 4iilA-3vkgA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 ARG A3957
GLU A4125
ASN A4234
 None
 0.81A 4imaD-3vkgA:
undetectable		 4imaD-3vkgA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 ARG A3957
GLU A4125
ASN A4234
 None
 0.82A 4ip7D-3vkgA:
undetectable		 4ip7D-3vkgA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 LEU A2131
LEU A2134
LEU A2139
ILE A2199
LEU A2152
 None
 1.11A 4j24A-3vkgA:
undetectable		 4j24A-3vkgA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 HIS A3223
GLY A3590
ILE A3626
 None
 0.64A 4k50A-3vkgA:
undetectable		 4k50A-3vkgA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 HIS A3223
GLY A3590
ILE A3626
 None
 0.63A 4k50I-3vkgA:
undetectable		 4k50I-3vkgA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 ARG A2965
ARG A3000
ASP A2927
ARG A2911
 None
 1.29A 4kr4C-3vkgA:
undetectable		 4kr4C-3vkgA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 LEU A4084
VAL A4027
LEU A4430
LEU A3992
 None
 1.02A 4l1xA-3vkgA:
undetectable		 4l1xA-3vkgA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 7 TYR A4317
VAL A4334
ILE A4310
ILE A4270
 None
 0.84A 4lv9A-3vkgA:
undetectable		 4lv9A-3vkgA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 7 TYR A4317
VAL A4334
ILE A4310
ILE A4270
 None
 0.87A 4lv9B-3vkgA:
undetectable		 4lv9B-3vkgA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 5 TYR A4287
ASP A4092
GLU A4412
VAL A4053
 None
SPM  A9016 ( 4.4A)
None
None
 1.49A 4nkvB-3vkgA:
undetectable		 4nkvB-3vkgA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 ASN A2381
ASP A2329
ASP A2341
 None
 0.72A 4obwD-3vkgA:
undetectable		 4obwD-3vkgA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 PRO A3717
MET A3761
TYR A3689
 None
 1.06A 4qa0B-3vkgA:
undetectable		 4qa0B-3vkgA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 10 TYR A1936
LEU A1781
ALA A1747
ALA A1727
GLY A1942
 None
 1.48A 4rn6A-3vkgA:
undetectable		 4rn6A-3vkgA:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_E_AZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 ASN A2390
HIS A2304
VAL A2391
LEU A2336
THR A2335
 None
 1.16A 4ygfE-3vkgA:
undetectable		 4ygfE-3vkgA:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_F_AZMF303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 9 ASN A2390
HIS A2304
VAL A2391
LEU A2336
THR A2335
 None
 1.15A 4ygfF-3vkgA:
undetectable		 4ygfF-3vkgA:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 10 ASN A2390
HIS A2304
VAL A2391
LEU A2336
THR A2335
 None
 1.19A 4yhaB-3vkgA:
undetectable		 4yhaB-3vkgA:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 10 ASN A2390
HIS A2304
VAL A2391
LEU A2336
THR A2335
 None
 1.12A 4yhaH-3vkgA:
undetectable		 4yhaH-3vkgA:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 ARG A3914
ASP A3918
TYR A3921
 None
 0.91A 4yo9B-3vkgA:
undetectable		 4yo9B-3vkgA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 6 ASN A4650
THR A4662
PRO A4663
VAL A4648
 None
 1.09A 4yoaA-3vkgA:
undetectable		 4yoaA-3vkgA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 7 LEU A3855
LEU A3834
ALA A3837
ALA A3841
LEU A3567
 None
 1.32A 4z90F-3vkgA:
undetectable
4z90G-3vkgA:
undetectable
4z90H-3vkgA:
undetectable
4z90J-3vkgA:
undetectable		 4z90F-3vkgA:
6.73
4z90G-3vkgA:
6.73
4z90H-3vkgA:
6.73
4z90J-3vkgA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 6 ILE A4255
PHE A4252
ARG A4269
THR A4387
 None
 1.00A 5b1aN-3vkgA:
undetectable
5b1aW-3vkgA:
undetectable		 5b1aN-3vkgA:
9.59
5b1aW-3vkgA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 7 SER A2860
TYR A2874
PHE A2864
HIS A2871
 None
 1.42A 5dlvB-3vkgA:
undetectable		 5dlvB-3vkgA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 6 LEU A4285
LEU A4410
LEU A4408
LEU A4355
 None
 0.71A 5gs4A-3vkgA:
undetectable		 5gs4A-3vkgA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 6 ARG A4286
PHE A4295
GLU A4239
VAL A4137
 None
 0.69A 5h4dA-3vkgA:
undetectable		 5h4dA-3vkgA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 6 HIS A2270
LEU A2387
CYH A2411
LEU A2367
 None
 1.03A 5hrqD-3vkgA:
undetectable
5hrqG-3vkgA:
undetectable
5hrqH-3vkgA:
undetectable		 5hrqD-3vkgA:
1.34
5hrqG-3vkgA:
0.68
5hrqH-3vkgA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 6 HIS A2270
LEU A2387
CYH A2411
LEU A2367
 None
 1.06A 5hrqB-3vkgA:
undetectable
5hrqI-3vkgA:
undetectable
5hrqJ-3vkgA:
undetectable		 5hrqB-3vkgA:
1.34
5hrqI-3vkgA:
0.68
5hrqJ-3vkgA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_ACTA305_0
(CARBONIC ANHYDRASE 4)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 4 GLN A4072
VAL A4077
GLU A3984
ILE A3983
 None
 1.21A 5jncA-3vkgA:
undetectable		 5jncA-3vkgA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_ACTA305_0
(CARBONIC ANHYDRASE 4)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 4 GLN A4072
VAL A4077
GLU A3987
ILE A3983
 None
 1.10A 5jncA-3vkgA:
undetectable		 5jncA-3vkgA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 HIS A4622
LYS A4620
PHE A4679
 None
 1.37A 5klaA-3vkgA:
undetectable		 5klaA-3vkgA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 MET A2766
GLN A2765
ARG A2764
 None
None
MG  A   1 ( 4.9A)
 1.07A 5m35B-3vkgA:
undetectable		 5m35B-3vkgA:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 MET A2766
GLN A2765
ARG A2764
 None
None
MG  A   1 ( 4.9A)
 1.05A 5m36A-3vkgA:
undetectable		 5m36A-3vkgA:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 LEU A3091
HIS A3142
SER A3036
GLY A3063
LEU A3059
 None
 1.22A 5m50E-3vkgA:
undetectable		 5m50E-3vkgA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 LYS A4635
TRP A4671
SER A4636
 None
 1.21A 5nwwA-3vkgA:
undetectable		 5nwwA-3vkgA:
1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 5 ALA A2159
VAL A2155
PHE A2118
ILE A2128
 None
 1.03A 5of1A-3vkgA:
undetectable		 5of1A-3vkgA:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 ASP A4352
LEU A4644
PRO A4289
GLY A4291
LEU A4290
 None
 1.25A 5ogcB-3vkgA:
undetectable		 5ogcB-3vkgA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 ASP A2005
ALA A2038
SER A4164
ARG A2011
LEU A2059
 None
 1.36A 5syfB-3vkgA:
undetectable		 5syfB-3vkgA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 GLU A2908
HIS A2907
ARG A2903
 None
 0.90A 5uunA-3vkgA:
undetectable		 5uunA-3vkgA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 7 VAL A3204
PRO A3202
ILE A3200
SER A3230
 None
 1.06A 5vkqA-3vkgA:
undetectable
5vkqD-3vkgA:
undetectable		 5vkqA-3vkgA:
20.03
5vkqD-3vkgA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 ALA A4306
LEU A4360
TYR A4317
TYR A1908
THR A1959
 None
 1.21A 5vlmD-3vkgA:
undetectable		 5vlmD-3vkgA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_2
(RIBOFLAVIN LYASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 4 ASN A3669
GLN A3266
ASP A3262
THR A3256
 None
 1.45A 5w4zB-3vkgA:
undetectable		 5w4zB-3vkgA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 7 ILE A4083
ARG A4424
MET A4426
LEU A4430
 None
SPM  A9016 ( 3.8A)
None
None
 0.97A 5xdqA-3vkgA:
undetectable
5xdqJ-3vkgA:
undetectable		 5xdqA-3vkgA:
9.59
5xdqJ-3vkgA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 5 ILE A4255
PHE A4252
ARG A4269
THR A4387
 None
 1.21A 5z84N-3vkgA:
undetectable
5z84W-3vkgA:
undetectable		 5z84N-3vkgA:
9.59
5z84W-3vkgA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 LEU A2050
ILE A2046
PHE A2074
VAL A1926
GLY A2023
 None
 1.16A 6a7pA-3vkgA:
undetectable		 6a7pA-3vkgA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 12 GLN A1813
THR A1812
VAL A1807
TYR A1803
LEU A1882
 None
 1.46A 6ak3A-3vkgA:
undetectable		 6ak3A-3vkgA:
2.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 ASN A2547
ARG A2543
HIS A2661
GLU A2550
 None
 1.11A 6b94A-3vkgA:
undetectable		 6b94A-3vkgA:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 8 LEU A3802
TYR A3886
THR A3809
ASN A3937
 None
 1.24A 6c71B-3vkgA:
undetectable		 6c71B-3vkgA:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 6 SER A1824
TYR A1912
GLN A1826
GLU A1881
 None
 1.38A 6djzA-3vkgA:
undetectable		 6djzA-3vkgA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 6 PHE A2691
VAL A2657
LEU A2670
LEU A2664
 None
 1.03A 6e43B-3vkgA:
undetectable		 6e43B-3vkgA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 6 PHE A2691
VAL A2657
LEU A2670
LEU A2664
 None
 1.02A 6e43D-3vkgA:
undetectable		 6e43D-3vkgA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 7 GLN A1962
GLY A2072
PHE A2074
GLY A1969
 None
 0.77A 6ekzA-3vkgA:
undetectable		 6ekzA-3vkgA:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 LEU A4033
SER A4031
PHE A4030
 None
 0.61A 6fgcA-3vkgA:
undetectable		 6fgcA-3vkgA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 11 MET A4260
ILE A4270
LEU A4273
ARG A4269
PRO A4384
 None
 1.13A 6fgcA-3vkgA:
undetectable		 6fgcA-3vkgA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 MET A2766
GLN A2765
ARG A2764
 None
None
MG  A   1 ( 4.9A)
 1.07A 6fn9A-3vkgA:
undetectable		 6fn9A-3vkgA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 MET A2766
GLN A2765
ARG A2764
 None
None
MG  A   1 ( 4.9A)
 1.05A 6fnaB-3vkgA:
undetectable		 6fnaB-3vkgA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 MET A2766
GLN A2765
ARG A2764
 None
None
MG  A   1 ( 4.9A)
 1.08A 6fnbA-3vkgA:
undetectable		 6fnbA-3vkgA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		5 / 9 LEU A1859
PHE A1875
GLU A1876
LEU A1867
VAL A1807
 None
 1.15A 6ftpA-3vkgA:
undetectable
6ftpB-3vkgA:
undetectable		 6ftpA-3vkgA:
2.29
6ftpB-3vkgA:
1.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 ASP A4092
ASP A4051
ASN A4650
 SPM  A9016 ( 4.4A)
None
None
 0.86A 6gngB-3vkgA:
undetectable		 6gngB-3vkgA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		4 / 7 HIS A1877
THR A1812
ARG A1872
GLU A1876
 None
 1.15A 6mn4E-3vkgA:
undetectable		 6mn4E-3vkgA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 ARG A2532
PHE A2537
PHE A2528
 None
 1.04A 6nknC-3vkgA:
undetectable
6nknJ-3vkgA:
undetectable		 6nknC-3vkgA:
6.07
6nknJ-3vkgA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 ARG A2532
PHE A2538
PHE A2528
 None
 1.06A 6nknC-3vkgA:
undetectable
6nknJ-3vkgA:
undetectable		 6nknC-3vkgA:
6.07
6nknJ-3vkgA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC
(Dictyostelium
discoideum) 		3 / 3 ARG A3667
PHE A3263
PHE A3637
 None
 1.08A 6nknC-3vkgA:
undetectable
6nknJ-3vkgA:
undetectable		 6nknC-3vkgA:
6.07
6nknJ-3vkgA:
1.82