SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vkw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		4 / 6 SER A1005
GLY A1002
LEU A1055
GLU A1026
 None
 0.80A 1fduD-3vkwA:
undetectable		 1fduD-3vkwA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		5 / 9 LEU A1028
VAL A1000
GLY A1002
LEU A1013
TYR A1033
 None
 1.35A 1lwfA-3vkwA:
undetectable		 1lwfA-3vkwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		4 / 6 ASP A1089
ARG A1054
ASP A1024
THR A1056
 None
 1.11A 2j2pE-3vkwA:
undetectable
2j2pF-3vkwA:
undetectable		 2j2pE-3vkwA:
17.18
2j2pF-3vkwA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		3 / 3 ARG A1076
ASN A 978
THR A 966
 SO4  A1203 (-2.7A)
None
None
 0.78A 2q63A-3vkwA:
undetectable		 2q63A-3vkwA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		4 / 7 ASN A 917
SER A 824
ALA A 928
ALA A 826
 None
 0.74A 3a2qA-3vkwA:
undetectable		 3a2qA-3vkwA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		4 / 7 ASN A 917
SER A 824
ALA A 928
ALA A 826
 None
 0.74A 3a2qA-3vkwA:
undetectable		 3a2qA-3vkwA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		5 / 12 THR A1038
GLU A1041
ILE A 940
LEU A1052
TYR A1083
 SO4  A1204 (-3.3A)
SO4  A1204 (-4.3A)
SO4  A1206 ( 4.5A)
None
None
 1.44A 3gwxB-3vkwA:
undetectable		 3gwxB-3vkwA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		4 / 5 ASN A 941
ASP A 711
GLU A 820
THR A 698
 None
 1.18A 3p2kC-3vkwA:
undetectable		 3p2kC-3vkwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		5 / 12 LEU A 687
ALA A 684
LEU A 728
ILE A 727
SER A 718
 None
 1.08A 4dm8B-3vkwA:
undetectable		 4dm8B-3vkwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		4 / 5 TYR A 931
THR A 974
LEU A 977
THR A 934
 None
 1.45A 4mbsB-3vkwA:
undetectable		 4mbsB-3vkwA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		5 / 12 VAL A1036
ALA A1034
SER A1030
GLY A1032
THR A1019
 None
 1.14A 4mm4A-3vkwA:
undetectable		 4mm4A-3vkwA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		5 / 12 VAL A1036
ALA A1034
SER A1030
GLY A1032
THR A1019
 None
 1.15A 4mm4B-3vkwA:
undetectable		 4mm4B-3vkwA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		4 / 6 GLU A1041
THR A1038
GLN A1022
LEU A1029
 SO4  A1204 (-4.3A)
SO4  A1204 (-3.3A)
SO4  A1204 (-3.8A)
None
 1.40A 4qzuC-3vkwA:
undetectable		 4qzuC-3vkwA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		3 / 3 ARG A 793
TYR A 773
GLU A 767
 None
 0.60A 4zzbE-3vkwA:
undetectable		 4zzbE-3vkwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		3 / 3 ASP A 886
LEU A 676
ARG A 810
 None
SO4  A1207 (-4.4A)
SO4  A1207 (-3.9A)
 0.82A 5e8qA-3vkwA:
undetectable		 5e8qA-3vkwA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		5 / 12 GLY A 908
GLY A 932
VAL A 916
ASP A 906
ILE A 905
 None
 1.04A 5ehiA-3vkwA:
undetectable		 5ehiA-3vkwA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		5 / 12 GLY A 908
GLY A 932
VAL A 916
ASP A 906
ILE A 905
 None
 1.02A 5eiwA-3vkwA:
undetectable		 5eiwA-3vkwA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		4 / 6 LYS A1016
LEU A1018
SER A1075
THR A1046
 None
 1.25A 5l4iB-3vkwA:
undetectable		 5l4iB-3vkwA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3vkw REPLICASE LARGE
SUBUNIT
(Tobacco
mosaic
virus) 		5 / 12 GLN A1022
THR A1038
VAL A1039
VAL A1042
VAL A1060
 SO4  A1204 (-3.8A)
SO4  A1204 (-3.3A)
None
None
None
 1.20A 6bzoC-3vkwA:
undetectable		 6bzoC-3vkwA:
16.47