SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vla'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 3vla EDGP
(Daucus
carota) 		5 / 9 LEU A 332
ILE A 330
VAL A 361
GLY A 360
LEU A 279
 None
 1.10A 1e7aB-3vlaA:
undetectable		 1e7aB-3vlaA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3vla EDGP
(Daucus
carota) 		5 / 12 VAL A 152
GLY A 153
LEU A  37
GLY A 150
VAL A  11
 None
 1.21A 1fduC-3vlaA:
undetectable		 1fduC-3vlaA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3vla EDGP
(Daucus
carota) 		4 / 4 ILE A 343
LEU A 253
VAL A 287
ILE A 246
 None
 0.91A 1fm6D-3vlaA:
undetectable		 1fm6D-3vlaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3vla EDGP
(Daucus
carota) 		4 / 7 LEU A 257
ILE A 270
THR A 268
TRP A 341
 NAG  A 601 ( 4.4A)
None
None
None
 1.19A 1kglA-3vlaA:
undetectable		 1kglA-3vlaA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3vla EDGP
(Daucus
carota) 		5 / 10 GLY A 310
LEU A 359
PHE A 291
ARG A 302
ILE A 292
 None
 1.08A 2f8dA-3vlaA:
undetectable		 2f8dA-3vlaA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3vla EDGP
(Daucus
carota) 		5 / 10 GLY A 310
LEU A 359
PHE A 291
ARG A 302
ILE A 292
 None
 1.09A 2f8dB-3vlaA:
undetectable		 2f8dB-3vlaA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 3vla EDGP
(Daucus
carota) 		4 / 5 SER A 185
THR A 405
SER A 183
ASP A 381
 None
 1.31A 2hdnB-3vlaA:
undetectable
2hdnC-3vlaA:
undetectable
2hdnD-3vlaA:
undetectable		 2hdnB-3vlaA:
21.56
2hdnC-3vlaA:
7.72
2hdnD-3vlaA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 3vla EDGP
(Daucus
carota) 		4 / 6 SER A 223
PRO A 233
SER A 225
VAL A 235
 None
 1.28A 2hdnI-3vlaA:
undetectable
2hdnJ-3vlaA:
undetectable
2hdnL-3vlaA:
undetectable		 2hdnI-3vlaA:
7.72
2hdnJ-3vlaA:
21.56
2hdnL-3vlaA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3vla EDGP
(Daucus
carota) 		4 / 8 MET A 180
LEU A 182
PRO A 165
GLY A  43
 None
 0.91A 2po5B-3vlaA:
undetectable		 2po5B-3vlaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3vla EDGP
(Daucus
carota) 		5 / 12 ILE A 372
GLY A 267
GLY A 240
LEU A 334
ILE A 239
 None
 1.08A 2y7kD-3vlaA:
undetectable		 2y7kD-3vlaA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3vla EDGP
(Daucus
carota) 		5 / 12 GLY A 158
GLY A 156
ASP A  40
LEU A 164
LEU A 388
 None
 1.13A 2zw9B-3vlaA:
undetectable		 2zw9B-3vlaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 3vla EDGP
(Daucus
carota) 		5 / 11 VAL A 287
THR A 277
ILE A 374
LEU A 332
THR A 268
 None
 1.34A 3bf1A-3vlaA:
undetectable
3bf1B-3vlaA:
undetectable		 3bf1A-3vlaA:
21.58
3bf1B-3vlaA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 3vla EDGP
(Daucus
carota) 		3 / 3 ASN A  99
ASP A  49
GLN A  52
 None
 0.71A 3eeyC-3vlaA:
undetectable		 3eeyC-3vlaA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 3vla EDGP
(Daucus
carota) 		3 / 3 ASN A  99
ASP A  49
GLN A  52
 None
 0.71A 3eeyD-3vlaA:
undetectable		 3eeyD-3vlaA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 3vla EDGP
(Daucus
carota) 		3 / 3 ASN A  99
ASP A  49
GLN A  52
 None
 0.70A 3eeyE-3vlaA:
undetectable		 3eeyE-3vlaA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vla EDGP
(Daucus
carota) 		5 / 11 PHE A 386
PHE A 178
GLY A  42
GLY A  43
ILE A 273
 None
 1.44A 3owxA-3vlaA:
undetectable
3owxB-3vlaA:
undetectable		 3owxA-3vlaA:
17.83
3owxB-3vlaA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 3vla EDGP
(Daucus
carota) 		3 / 3 ARG A   5
PRO A 132
PHE A 172
 None
 0.87A 3thrC-3vlaA:
undetectable		 3thrC-3vlaA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3vla EDGP
(Daucus
carota) 		3 / 3 PHE A 409
VAL A  10
GLU A 118
 None
 0.61A 4fvqA-3vlaA:
undetectable		 4fvqA-3vlaA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3vla EDGP
(Daucus
carota) 		4 / 5 GLY A  42
ILE A 270
LEU A 182
LEU A 147
 None
 0.87A 4o8fA-3vlaA:
undetectable		 4o8fA-3vlaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3vla EDGP
(Daucus
carota) 		4 / 5 ILE A 193
PHE A 395
SER A 123
ASP A 209
 None
 1.37A 4rzvB-3vlaA:
undetectable		 4rzvB-3vlaA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vla EDGP
(Daucus
carota) 		5 / 11 PHE A 386
PHE A 178
GLY A  42
GLY A  43
ILE A 273
 None
 1.43A 4zvmA-3vlaA:
undetectable
4zvmB-3vlaA:
undetectable		 4zvmA-3vlaA:
17.83
4zvmB-3vlaA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3vla EDGP
(Daucus
carota) 		3 / 3 ASP A 121
ASN A 196
PHE A 172
 None
 0.58A 5dsgB-3vlaA:
undetectable		 5dsgB-3vlaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3vla EDGP
(Daucus
carota) 		3 / 3 ASP A 121
ASN A 196
PHE A 194
 None
 0.58A 5dsgB-3vlaA:
undetectable		 5dsgB-3vlaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3vla EDGP
(Daucus
carota) 		5 / 12 VAL A 241
LEU A 258
SER A 282
ILE A 244
LEU A 359
 None
 0.97A 5hbsA-3vlaA:
undetectable		 5hbsA-3vlaA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 3vla EDGP
(Daucus
carota) 		5 / 12 GLY A 345
GLY A 324
SER A 320
THR A 344
HIS A 377
 None
 1.14A 5kocB-3vlaA:
undetectable		 5kocB-3vlaA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3vla EDGP
(Daucus
carota) 		4 / 6 LEU A 257
ILE A 239
THR A 268
TRP A 341
 NAG  A 601 ( 4.4A)
None
None
None
 1.44A 5ljeA-3vlaA:
undetectable		 5ljeA-3vlaA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3vla EDGP
(Daucus
carota) 		4 / 6 LEU A 257
ILE A 270
THR A 268
TRP A 341
 NAG  A 601 ( 4.4A)
None
None
None
 1.22A 5ljeA-3vlaA:
undetectable		 5ljeA-3vlaA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3vla EDGP
(Daucus
carota) 		4 / 4 VAL A  48
VAL A 152
TYR A  54
GLN A  52
 None
 1.38A 5qggA-3vlaA:
undetectable		 5qggA-3vlaA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3vla EDGP
(Daucus
carota) 		4 / 4 VAL A  48
VAL A 152
TYR A  54
GLN A  52
 None
 1.37A 5qgoA-3vlaA:
undetectable		 5qgoA-3vlaA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3vla EDGP
(Daucus
carota) 		4 / 4 VAL A  48
VAL A 152
TYR A  54
GLN A  52
 None
 1.37A 5qgpA-3vlaA:
undetectable		 5qgpA-3vlaA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3vla EDGP
(Daucus
carota) 		4 / 4 VAL A  48
VAL A 152
TYR A  54
GLN A  52
 None
 1.33A 5qgqA-3vlaA:
undetectable		 5qgqA-3vlaA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3vla EDGP
(Daucus
carota) 		4 / 4 VAL A  48
VAL A 152
TYR A  54
GLN A  52
 None
 1.39A 5qhbA-3vlaA:
undetectable		 5qhbA-3vlaA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3vla EDGP
(Daucus
carota) 		5 / 10 LEU A 143
ALA A 139
SER A 225
VAL A  95
ARG A  44
 None
 1.39A 6b89A-3vlaA:
undetectable		 6b89A-3vlaA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3vla EDGP
(Daucus
carota) 		5 / 10 LEU A 143
ALA A 139
SER A 225
VAL A  95
ARG A  44
 None
 1.44A 6b89B-3vlaA:
undetectable		 6b89B-3vlaA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3vla EDGP
(Daucus
carota) 		5 / 10 ALA A 179
LEU A 383
LEU A 212
TYR A 214
VAL A 207
 None
 1.29A 6g2pB-3vlaA:
undetectable		 6g2pB-3vlaA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3vla EDGP
(Daucus
carota) 		3 / 3 LYS A  14
SER A 183
SER A 185
 None
 1.04A 6gbfA-3vlaA:
undetectable		 6gbfA-3vlaA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 3vla EDGP
(Daucus
carota) 		4 / 6 THR A 398
LEU A 399
THR A 342
LEU A 379
 None
 0.90A 6mvxA-3vlaA:
undetectable
6mvxB-3vlaA:
undetectable
6mvxC-3vlaA:
undetectable		 6mvxA-3vlaA:
20.95
6mvxB-3vlaA:
20.95
6mvxC-3vlaA:
20.95