SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vly'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		3 / 3 ALA A 245
VAL A 261
TRP A 225
 None
 0.93A 1grmA-3vlyA:
undetectable		 1grmA-3vlyA:
3.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		3 / 3 ALA A 245
VAL A 261
TRP A 225
 None
 0.93A 1grmB-3vlyA:
undetectable		 1grmB-3vlyA:
3.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		5 / 12 LEU A 171
LEU A 163
ALA A 138
MET A 108
LEU A  95
 None
 1.39A 1kt5A-3vlyA:
undetectable		 1kt5A-3vlyA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		5 / 11 LEU A 171
LEU A 163
ALA A 138
MET A 108
LEU A  95
 None
 1.40A 1kt6A-3vlyA:
undetectable		 1kt6A-3vlyA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		4 / 5 PRO A 239
GLY A 183
ASN A 184
GLY A 231
 None
 1.15A 1zlqA-3vlyA:
undetectable		 1zlqA-3vlyA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		5 / 12 LEU A 110
LEU A 125
GLY A 162
SER A 127
ALA A 164
 None
 1.05A 2bm9D-3vlyA:
undetectable		 2bm9D-3vlyA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		5 / 10 ALA A 278
LEU A 335
GLU A 320
LEU A 260
VAL A 261
 None
 1.06A 2bxeA-3vlyA:
undetectable		 2bxeA-3vlyA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		5 / 9 LEU A 153
PHE A 106
LEU A  68
ARG A  89
LEU A  59
 None
 1.19A 2bxeA-3vlyA:
undetectable		 2bxeA-3vlyA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		5 / 11 LEU A 369
GLY A 374
SER A 427
LEU A 423
SER A 424
 None
K  A 603 ( 4.6A)
None
None
None
 0.88A 2qmmA-3vlyA:
undetectable
2qmmB-3vlyA:
undetectable		 2qmmA-3vlyA:
15.49
2qmmB-3vlyA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		4 / 6 LEU A 398
LEU A 112
ILE A 404
ARG A 397
 None
 0.90A 2rlfA-3vlyA:
undetectable
2rlfB-3vlyA:
undetectable		 2rlfA-3vlyA:
5.53
2rlfB-3vlyA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		4 / 6 LEU A 398
LEU A 112
ILE A 404
ARG A 397
 None
 0.94A 2rlfC-3vlyA:
undetectable
2rlfD-3vlyA:
undetectable		 2rlfC-3vlyA:
5.53
2rlfD-3vlyA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		4 / 5 VAL A 229
TYR A 200
VAL A 195
ASP A 196
 None
 1.22A 2x45A-3vlyA:
undetectable		 2x45A-3vlyA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		4 / 5 VAL A 229
TYR A 200
VAL A 195
ASP A 196
 None
 1.31A 2x45C-3vlyA:
undetectable		 2x45C-3vlyA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		5 / 11 VAL A 422
VAL A 376
SER A 427
ILE A 371
ALA A 385
 None
 1.19A 2zbzA-3vlyA:
undetectable		 2zbzA-3vlyA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		3 / 3 PRO A 222
PHE A 264
LYS A 224
 None
None
SO3  A 606 ( 2.2A)
 1.01A 3bjwG-3vlyA:
undetectable		 3bjwG-3vlyA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		4 / 5 ARG A 329
ARG A 323
GLY A 321
GLU A 320
 None
 1.29A 3k9fA-3vlyA:
1.6
3k9fB-3vlyA:
1.6
3k9fC-3vlyA:
undetectable		 3k9fA-3vlyA:
22.24
3k9fB-3vlyA:
22.24
3k9fC-3vlyA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		5 / 12 ILE A 493
ALA A 491
LEU A 515
VAL A 464
ILE A 460
 None
 0.92A 3oapA-3vlyA:
undetectable		 3oapA-3vlyA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		4 / 6 ILE A  65
LEU A  90
PHE A 106
GLY A 104
 None
 1.04A 3sj1X-3vlyA:
undetectable		 3sj1X-3vlyA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		4 / 8 ILE A 396
ILE A 404
VAL A 376
GLY A 374
 None
None
None
K  A 603 ( 4.6A)
 0.80A 4acaC-3vlyA:
undetectable		 4acaC-3vlyA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		4 / 8 ILE A 396
ILE A 404
VAL A 376
GLY A 374
 None
None
None
K  A 603 ( 4.6A)
 0.81A 4acbC-3vlyA:
undetectable		 4acbC-3vlyA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		4 / 8 PRO A 227
VAL A 178
VAL A 229
GLY A 183
 None
 0.90A 4mk4A-3vlyA:
2.0		 4mk4A-3vlyA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		3 / 3 ARG A 375
GLU A 452
ARG A 149
 None
None
SRM  A 601 (-2.9A)
 0.92A 4mwvA-3vlyA:
undetectable		 4mwvA-3vlyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		5 / 9 LEU A 299
LEU A 276
ARG A 323
LEU A 317
ILE A 314
 None
 1.34A 4ubsA-3vlyA:
undetectable		 4ubsA-3vlyA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		4 / 5 ARG A 329
ARG A 323
GLY A 321
GLU A 320
 None
 1.25A 4z3oA-3vlyA:
2.6
4z3oB-3vlyA:
2.2		 4z3oA-3vlyA:
22.32
4z3oB-3vlyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		4 / 7 ARG A 329
ARG A 323
GLY A 321
GLU A 320
 None
 1.05A 5btfA-3vlyA:
1.4
5btfC-3vlyA:
1.3
5btfD-3vlyA:
undetectable		 5btfA-3vlyA:
22.12
5btfC-3vlyA:
22.12
5btfD-3vlyA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		4 / 5 ARG A 323
GLY A 321
GLU A 320
ARG A 329
 None
 1.10A 5cdqA-3vlyA:
undetectable
5cdqB-3vlyA:
undetectable
5cdqC-3vlyA:
undetectable		 5cdqA-3vlyA:
23.05
5cdqB-3vlyA:
13.36
5cdqC-3vlyA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3vly NITRITE REDUCTASE
(Nicotiana
tabacum) 		5 / 12 LEU A 470
LEU A 433
LEU A 546
GLY A 516
LEU A 515
 None
 0.93A 6b0cD-3vlyA:
undetectable		 6b0cD-3vlyA:
9.41