SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		6 / 12 ILE A  36
LEU A  70
VAL A  28
ALA A 316
ILE A 320
ILE A 300
 None
 1.33A 1epbA-3vmlA:
undetectable		 1epbA-3vmlA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		6 / 12 ILE A  36
LEU A  70
VAL A  28
ALA A 316
ILE A 320
ILE A 300
 None
 1.32A 1epbB-3vmlA:
undetectable		 1epbB-3vmlA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 10 SER A 310
TYR A 278
GLY A 274
HIS A  99
GLU A  64
 None
 1.25A 1equA-3vmlA:
undetectable		 1equA-3vmlA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		4 / 6 GLY A 335
GLY A 331
TYR A 332
SER A 339
 None
 0.85A 1eswA-3vmlA:
undetectable		 1eswA-3vmlA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		4 / 7 LEU A 246
GLY A 248
LEU A 138
TYR A 143
 CL  A 403 (-4.6A)
None
None
IPM  A 401 (-4.5A)
 1.03A 1gtiD-3vmlA:
undetectable		 1gtiD-3vmlA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		4 / 7 LEU A 246
GLY A 248
LEU A 138
TYR A 143
 CL  A 403 (-4.6A)
None
None
IPM  A 401 (-4.5A)
 1.02A 1gtiE-3vmlA:
undetectable		 1gtiE-3vmlA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 12 ARG A 107
ILE A 132
SER A 252
ILE A 255
ALA A 256
 IPM  A 401 (-4.5A)
None
None
None
None
 1.03A 2bxqA-3vmlA:
undetectable		 2bxqA-3vmlA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		4 / 5 TYR A   3
ILE A  36
LEU A 306
LEU A 307
 None
 1.13A 2zb7A-3vmlA:
undetectable		 2zb7A-3vmlA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 9 ILE A  36
TYR A   3
ILE A   5
LEU A 306
LEU A 307
 None
 0.86A 3f78A-3vmlA:
2.3		 3f78A-3vmlA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 9 ILE A  36
TYR A   3
ILE A   5
LEU A 306
LEU A 307
 None
 0.86A 3f78B-3vmlA:
2.4		 3f78B-3vmlA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		4 / 8 SER A 284
ILE A  48
PRO A  88
GLY A  44
 None
 0.96A 3lslA-3vmlA:
2.9
3lslD-3vmlA:
2.8		 3lslA-3vmlA:
22.60
3lslD-3vmlA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 11 GLY A  98
LEU A 138
ASN A 105
ASN A 245
LEU A  93
 None
 1.31A 3ndvC-3vmlA:
undetectable
3ndvD-3vmlA:
undetectable		 3ndvC-3vmlA:
23.89
3ndvD-3vmlA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 12 GLY A  14
GLY A  45
GLY A  75
GLY A  12
ASP A  86
 None
 0.86A 3p97A-3vmlA:
undetectable		 3p97A-3vmlA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 12 GLY A  14
GLY A  45
GLY A  75
GLY A  12
ASP A  86
 None
 0.84A 4ctjA-3vmlA:
undetectable		 4ctjA-3vmlA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 12 GLY A  14
GLY A  45
GLY A  75
GLY A  12
ASP A  86
 None
 0.86A 4ctkA-3vmlA:
undetectable		 4ctkA-3vmlA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 9 VAL A 297
ALA A 298
GLY A 335
SER A 261
GLY A 263
 None
 1.41A 4mmeA-3vmlA:
undetectable		 4mmeA-3vmlA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 12 GLY A  14
GLY A  45
GLY A  75
GLY A  12
ASP A  86
 None
 0.86A 5e9qA-3vmlA:
undetectable		 5e9qA-3vmlA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 12 GLY A  14
GLY A  45
GLY A  75
GLY A  12
ASP A  86
 None
 0.88A 5ec8C-3vmlA:
undetectable		 5ec8C-3vmlA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		6 / 12 GLY A  14
GLY A  45
GLY A  75
GLY A  12
GLU A  89
ASP A  86
 None
None
None
None
IPM  A 401 ( 4.5A)
None
 1.28A 5ehgA-3vmlA:
undetectable		 5ehgA-3vmlA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 12 GLY A  14
GLY A  45
GLY A  75
GLY A  12
ASP A  86
 None
 0.85A 5eifA-3vmlA:
undetectable		 5eifA-3vmlA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 12 GLY A  14
GLY A  45
GLY A  75
GLY A  12
ASP A  86
 None
 0.89A 5eifC-3vmlA:
undetectable		 5eifC-3vmlA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 12 GLY A  14
GLY A  45
GLY A  75
GLY A  12
ASP A  86
 None
 0.89A 5ikmA-3vmlA:
undetectable		 5ikmA-3vmlA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 12 GLY A  14
GLY A  45
GLY A  75
GLY A  12
ASP A  86
 None
 0.88A 5kqrA-3vmlA:
undetectable		 5kqrA-3vmlA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 12 GLY A  14
GLY A  45
GLY A  75
GLY A  12
ASP A  86
 None
 0.87A 5kqsA-3vmlA:
undetectable		 5kqsA-3vmlA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 12 VAL A  43
ASP A  42
LEU A 306
GLN A   4
GLY A  62
 None
 1.24A 5m50E-3vmlA:
3.3		 5m50E-3vmlA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 12 GLY A  14
GLY A  45
GLY A  75
GLY A  12
ASP A  86
 None
 0.88A 5m5bA-3vmlA:
undetectable		 5m5bA-3vmlA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 12 GLY A  14
GLY A  45
GLY A  75
GLY A  12
ASP A  86
 None
 0.85A 5njvA-3vmlA:
undetectable		 5njvA-3vmlA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 3vml 3-ISOPROPYLMALATE
DEHYDROGENASE
(Shewanella
benthica;
Shewanella
oneidensis) 		5 / 12 GLY A  14
GLY A  45
GLY A  75
GLY A  12
ASP A  86
 None
 0.85A 5njvB-3vmlA:
undetectable		 5njvB-3vmlA:
22.89