SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vmw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		5 / 9 LEU A  99
ILE A  56
ILE A  84
VAL A  68
ILE A  97
 None
 1.00A 1ohrB-3vmwA:
undetectable		 1ohrB-3vmwA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		5 / 12 VAL A  52
ILE A 112
ILE A  97
ILE A 105
ILE A 123
 None
 1.27A 1r5lA-3vmwA:
undetectable		 1r5lA-3vmwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		5 / 12 VAL A  52
ILE A 112
ILE A  97
VAL A  68
ILE A 123
 None
 1.25A 1r5lA-3vmwA:
undetectable		 1r5lA-3vmwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		3 / 3 PHE A 298
TYR A 302
TYR A 304
 None
 0.95A 1x70B-3vmwA:
undetectable		 1x70B-3vmwA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		4 / 6 GLU A 163
TYR A 164
ASP A 215
ARG A 238
 None
None
None
SO4  A 905 (-3.1A)
 1.50A 2a3bB-3vmwA:
undetectable		 2a3bB-3vmwA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		5 / 9 ASP A  67
GLY A  96
ILE A 123
VAL A  52
ILE A  31
 None
 1.29A 3ekyB-3vmwA:
undetectable		 3ekyB-3vmwA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		4 / 6 ILE A 231
THR A 178
PHE A 172
TYR A 196
 None
 0.95A 3elzB-3vmwA:
undetectable		 3elzB-3vmwA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		4 / 7 TYR A   7
ILE A 134
MET A 218
ARG A 160
 None
None
None
SO4  A 907 (-3.3A)
 1.10A 3ik3B-3vmwA:
undetectable		 3ik3B-3vmwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		3 / 3 ARG A  98
LYS A  74
ARG A 160
 None
SO4  A 906 (-4.5A)
SO4  A 907 (-3.3A)
 1.47A 3w1wA-3vmwA:
undetectable
3w1wB-3vmwA:
undetectable		 3w1wA-3vmwA:
21.69
3w1wB-3vmwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		6 / 12 LEU A  99
ILE A  66
ILE A  56
ILE A  84
VAL A  68
ILE A  97
 None
 1.25A 4q1xB-3vmwA:
undetectable		 4q1xB-3vmwA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		4 / 5 ILE A  97
HIS A 175
TYR A 196
VAL A 167
 None
 1.26A 4s0vA-3vmwA:
undetectable		 4s0vA-3vmwA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		5 / 9 PHE A  92
ILE A  97
GLY A  28
LEU A  34
LEU A  48
 None
 1.30A 4ze0A-3vmwA:
undetectable		 4ze0A-3vmwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_B_QMRB1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		5 / 10 TYR A 302
VAL A 216
VAL A 181
MET A 158
ILE A 165
 None
 1.48A 5ainB-3vmwA:
0.0
5ainC-3vmwA:
0.0		 5ainB-3vmwA:
19.64
5ainC-3vmwA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		4 / 7 GLY A  96
GLY A 118
TYR A 152
ALA A 122
 None
 0.95A 5e26A-3vmwA:
undetectable
5e26B-3vmwA:
undetectable		 5e26A-3vmwA:
20.88
5e26B-3vmwA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		4 / 6 GLY A 120
THR A 121
VAL A 115
HIS A 175
 None
 1.15A 5ewuA-3vmwA:
undetectable		 5ewuA-3vmwA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		4 / 6 GLY A 120
THR A 121
VAL A 115
HIS A 175
 None
 1.14A 5ewuB-3vmwA:
undetectable		 5ewuB-3vmwA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		5 / 12 ILE A  31
ILE A  84
PHE A  92
LEU A  48
THR A  49
 None
 1.31A 5tiwB-3vmwA:
undetectable		 5tiwB-3vmwA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		3 / 3 THR A 121
GLU A 124
HIS A 183
 None
None
SO4  A 904 ( 3.8A)
 0.67A 5xioA-3vmwA:
undetectable		 5xioA-3vmwA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		3 / 3 THR A 121
GLU A 124
HIS A 183
 None
None
SO4  A 904 ( 3.8A)
 0.67A 5xiqB-3vmwA:
undetectable		 5xiqB-3vmwA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		3 / 3 THR A 121
GLU A 124
HIS A 183
 None
None
SO4  A 904 ( 3.8A)
 0.73A 5xiqD-3vmwA:
undetectable		 5xiqD-3vmwA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3vmw PECTATE LYASE
(Bacillus
sp.
N16-5) 		5 / 12 VAL A 181
MET A 218
PHE A 284
PRO A 264
GLY A 266
 None
 1.15A 6brdC-3vmwA:
undetectable		 6brdC-3vmwA:
13.29