SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vn3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 12 ILE A 158
GLY A 112
SER A 129
PHE A 185
ALA A 109
 None
None
None
None
EDO  A 304 (-3.5A)
 1.08A 1sg9C-3vn3A:
undetectable		 1sg9C-3vn3A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		6 / 12 ILE A  16
ALA A 209
ALA A  18
ALA A 191
VAL A  63
LEU A  44
 None
None
None
IYR  A  91 ( 4.3A)
None
None
 1.42A 1xiuB-3vn3A:
undetectable		 1xiuB-3vn3A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 11 TYR A  14
LEU A  17
ILE A  79
THR A  76
PRO A  75
 EDO  A 303 (-4.2A)
None
None
None
None
 1.34A 2ft9A-3vn3A:
undetectable		 2ft9A-3vn3A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		4 / 7 GLU A 186
TRP A 142
LYS A 167
GLY A 187
 None
 1.21A 2hs1B-3vn3A:
undetectable		 2hs1B-3vn3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 12 THR A  10
ASN A  13
VAL A  36
GLY A  35
THR A  76
 None
EDO  A 303 (-4.1A)
None
None
None
 1.12A 3bf1A-3vn3A:
undetectable
3bf1B-3vn3A:
undetectable		 3bf1A-3vn3A:
22.18
3bf1B-3vn3A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 12 ALA A 153
GLY A 182
GLY A 155
GLN A 216
ILE A 207
 None
 0.97A 3douA-3vn3A:
undetectable		 3douA-3vn3A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		6 / 12 ILE A  16
ALA A 209
ALA A  18
ALA A 191
VAL A  63
LEU A  44
 None
None
None
IYR  A  91 ( 4.3A)
None
None
 1.45A 3oapA-3vn3A:
undetectable		 3oapA-3vn3A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 10 VAL A 177
ILE A 189
GLY A 187
VAL A 152
ILE A 179
 None
 1.06A 3oxvB-3vn3A:
undetectable		 3oxvB-3vn3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		4 / 5 LEU A 190
LEU A   8
GLY A   9
GLY A  12
 IYR  A  91 ( 4.0A)
EDO  A 301 ( 4.9A)
None
None
 0.83A 3si7C-3vn3A:
undetectable
3si7D-3vn3A:
undetectable		 3si7C-3vn3A:
23.43
3si7D-3vn3A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 10 ARG A  97
GLY A 118
TRP A 142
THR A 139
THR A 137
 None
 1.44A 3wg7G-3vn3A:
undetectable
3wg7N-3vn3A:
undetectable
3wg7O-3vn3A:
undetectable		 3wg7G-3vn3A:
17.49
3wg7N-3vn3A:
18.09
3wg7O-3vn3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 10 ARG A  97
GLY A 118
TRP A 142
THR A 139
THR A 137
 None
 1.41A 3x2qG-3vn3A:
undetectable
3x2qN-3vn3A:
undetectable
3x2qO-3vn3A:
undetectable		 3x2qG-3vn3A:
17.49
3x2qN-3vn3A:
18.09
3x2qO-3vn3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 12 VAL A 173
ALA A 174
GLY A 127
SER A 124
GLY A 148
 IYR  A  91 ( 3.8A)
IYR  A  91 ( 3.7A)
None
None
None
 1.18A 4mmdB-3vn3A:
undetectable		 4mmdB-3vn3A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 11 ARG A  97
GLY A 118
TRP A 142
THR A 139
THR A 137
 None
 1.37A 5w97G-3vn3A:
undetectable
5w97a-3vn3A:
undetectable
5w97b-3vn3A:
undetectable		 5w97G-3vn3A:
17.49
5w97a-3vn3A:
18.09
5w97b-3vn3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 11 TRP A 142
THR A 139
THR A 137
ARG A  97
GLY A 118
 None
 1.34A 5w97A-3vn3A:
undetectable
5w97B-3vn3A:
undetectable
5w97g-3vn3A:
undetectable		 5w97A-3vn3A:
18.09
5w97B-3vn3A:
22.58
5w97g-3vn3A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 10 ARG A  97
GLY A 118
TRP A 142
THR A 139
THR A 137
 None
 1.38A 5wauG-3vn3A:
undetectable
5waua-3vn3A:
undetectable
5waub-3vn3A:
undetectable		 5wauG-3vn3A:
17.49
5waua-3vn3A:
18.09
5waub-3vn3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		6 / 12 ILE A  16
ALA A 209
ALA A  18
ALA A 191
VAL A  63
LEU A  44
 None
None
None
IYR  A  91 ( 4.3A)
None
None
 1.42A 5z12B-3vn3A:
undetectable		 5z12B-3vn3A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 11 TRP A 142
THR A 139
THR A 137
ARG A  97
GLY A 118
 None
 1.45A 5z86A-3vn3A:
0.3
5z86B-3vn3A:
undetectable
5z86T-3vn3A:
undetectable		 5z86A-3vn3A:
18.09
5z86B-3vn3A:
22.58
5z86T-3vn3A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 10 ARG A  97
GLY A 118
TRP A 142
THR A 139
THR A 137
 None
 1.45A 5z86G-3vn3A:
undetectable
5z86N-3vn3A:
undetectable
5z86O-3vn3A:
undetectable		 5z86G-3vn3A:
17.49
5z86N-3vn3A:
18.09
5z86O-3vn3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		4 / 7 THR A 113
LEU A 110
ILE A 158
TYR A 120
 EDO  A 304 ( 4.7A)
None
None
None
 0.81A 5zsfA-3vn3A:
1.4
5zsfB-3vn3A:
1.3		 5zsfA-3vn3A:
15.42
5zsfB-3vn3A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 9 ARG A  97
GLY A 118
TRP A 142
THR A 139
THR A 137
 None
 1.39A 6nknG-3vn3A:
0.0
6nknN-3vn3A:
undetectable
6nknO-3vn3A:
0.0		 6nknG-3vn3A:
17.49
6nknN-3vn3A:
18.09
6nknO-3vn3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vn3 ANTIFREEZE PROTEIN
(Typhula
ishikariensis) 		5 / 9 TRP A 142
THR A 139
THR A 137
ARG A  97
GLY A 118
 None
 1.37A 6nmfA-3vn3A:
undetectable
6nmfB-3vn3A:
0.0
6nmfT-3vn3A:
0.0		 6nmfA-3vn3A:
18.09
6nmfB-3vn3A:
22.58
6nmfT-3vn3A:
17.49