SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vn4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 3vn4 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 13
(Homo
sapiens) 		4 / 7 GLY A 491
ASP A 454
HIS A 469
ALA A 451
 None
 0.89A 1gxsA-3vn4A:
undetectable
1gxsB-3vn4A:
undetectable		 1gxsA-3vn4A:
20.39
1gxsB-3vn4A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3vn4 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 13
(Homo
sapiens) 		4 / 5 PHE A 530
GLY A 403
SER A 394
THR A 406
 None
 1.26A 1icuC-3vn4A:
undetectable
1icuD-3vn4A:
undetectable		 1icuC-3vn4A:
18.20
1icuD-3vn4A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3vn4 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 13
(Homo
sapiens) 		5 / 12 ILE A 673
ALA A 586
ARG A 639
ILE A 611
PHE A 573
 None
 1.45A 1y0xX-3vn4A:
undetectable		 1y0xX-3vn4A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 3vn4 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 13
(Homo
sapiens) 		4 / 7 LEU A 374
TRP A 365
ALA A 417
GLY A 420
 None
 0.97A 2wq5A-3vn4A:
undetectable		 2wq5A-3vn4A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3vn4 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 13
(Homo
sapiens) 		5 / 12 GLY A 479
LEU A 521
SER A 520
ARG A 398
MET A 486
 None
None
None
BGC  A 904 (-4.1A)
None
 1.04A 3bxoB-3vn4A:
undetectable		 3bxoB-3vn4A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3vn4 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 13
(Homo
sapiens) 		5 / 9 MET A 432
LEU A 521
ARG A 625
SER A 538
GLY A 517
 None
 1.33A 3hcnB-3vn4A:
undetectable		 3hcnB-3vn4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3vn4 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 13
(Homo
sapiens) 		4 / 5 SER A 612
THR A 615
GLU A 641
ASP A 672
 None
 1.35A 3tm4A-3vn4A:
undetectable		 3tm4A-3vn4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3vn4 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 13
(Homo
sapiens) 		4 / 5 SER A 612
THR A 615
GLU A 641
ASP A 672
 None
 1.36A 3tm4B-3vn4A:
undetectable		 3tm4B-3vn4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3vn4 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 13
(Homo
sapiens) 		5 / 12 LEU A 649
ILE A 645
THR A 615
VAL A 597
VAL A 605
 None
 1.15A 4nkvA-3vn4A:
undetectable		 4nkvA-3vn4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 3vn4 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 13
(Homo
sapiens) 		4 / 6 ARG A 660
ARG A 659
ILE A 673
THR A 563
 None
 1.01A 5vceA-3vn4A:
undetectable		 5vceA-3vn4A:
19.84