SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vn5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3vn5 RIBONUCLEASE HIII
(Aquifex
aeolicus) 		3 / 3 PHE A 187
ASN A 185
PHE A 193
 None
 0.95A 2zbuD-3vn5A:
undetectable		 2zbuD-3vn5A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 3vn5 RIBONUCLEASE HIII
(Aquifex
aeolicus) 		4 / 8 GLY A  86
PRO A 139
LYS A 213
ARG A 211
 None
 0.94A 3bjwA-3vn5A:
undetectable		 3bjwA-3vn5A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 3vn5 RIBONUCLEASE HIII
(Aquifex
aeolicus) 		5 / 9 ILE A   6
ILE A  14
LYS A  13
LEU A  67
LEU A  68
 None
 1.46A 3f78A-3vn5A:
undetectable		 3f78A-3vn5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 3vn5 RIBONUCLEASE HIII
(Aquifex
aeolicus) 		4 / 6 TYR A 142
MET A 155
ASN A 153
LEU A 152
 None
 1.47A 3lslG-3vn5A:
undetectable		 3lslG-3vn5A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3vn5 RIBONUCLEASE HIII
(Aquifex
aeolicus) 		5 / 6 PHE A 214
ARG A 211
LEU A  88
GLU A  78
SER A  79
 None
 1.43A 3vlnA-3vn5A:
undetectable		 3vlnA-3vn5A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3vn5 RIBONUCLEASE HIII
(Aquifex
aeolicus) 		4 / 7 TYR A 142
TYR A 146
ASN A 151
TYR A 181
 None
 1.36A 4f8yC-3vn5A:
undetectable
4f8yD-3vn5A:
undetectable		 4f8yC-3vn5A:
19.62
4f8yD-3vn5A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 3vn5 RIBONUCLEASE HIII
(Aquifex
aeolicus) 		5 / 12 LEU A 218
VAL A 221
ILE A 251
ILE A  84
VAL A 237
 None
 1.16A 4y0pA-3vn5A:
undetectable		 4y0pA-3vn5A:
20.87