SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vnd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3vnd TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Shewanella
frigidimarina) 		4 / 8 GLU A  32
ASP A  28
ILE A  37
LEU A 252
 None
 0.95A 1hmyA-3vndA:
undetectable		 1hmyA-3vndA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 3vnd TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Shewanella
frigidimarina) 		4 / 8 ILE A  26
LEU A 106
VAL A 107
LEU A 102
 None
 0.87A 2w98B-3vndA:
undetectable		 2w98B-3vndA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3vnd TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Shewanella
frigidimarina) 		5 / 12 PHE A 140
PHE A 115
PRO A 139
ALA A 138
ALA A 109
 None
 1.29A 2x2nA-3vndA:
undetectable		 2x2nA-3vndA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3vnd TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Shewanella
frigidimarina) 		5 / 12 PHE A 140
PHE A 115
PRO A 139
ALA A 138
ALA A 109
 None
 1.25A 2x2nB-3vndA:
undetectable		 2x2nB-3vndA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3vnd TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Shewanella
frigidimarina) 		4 / 8 PRO A 139
ALA A 143
ALA A 146
ILE A 112
 None
 0.69A 3dtuC-3vndA:
undetectable
3dtuD-3vndA:
undetectable		 3dtuC-3vndA:
19.79
3dtuD-3vndA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3vnd TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Shewanella
frigidimarina) 		5 / 12 GLY A  27
THR A  77
ASP A  28
ILE A  38
ASP A  81
 None
 1.34A 3iv6B-3vndA:
undetectable		 3iv6B-3vndA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3vnd TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Shewanella
frigidimarina) 		5 / 11 LEU A 100
PHE A  53
VAL A 107
ILE A  86
ALA A 122
 None
 1.13A 3mdtB-3vndA:
undetectable		 3mdtB-3vndA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 3vnd TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Shewanella
frigidimarina) 		4 / 6 PRO A 209
ILE A 194
GLY A 228
GLU A 195
 None
 1.02A 6gqiA-3vndA:
undetectable		 6gqiA-3vndA:
19.34