SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vnp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 3vnp HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		3 / 3 THR A   9
THR A  25
PRO A   4
 None
 0.83A 1dscC-3vnpA:
undetectable		 1dscC-3vnpA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 3vnp HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		5 / 9 ILE A 102
VAL A  83
GLY A  97
ILE A 126
ILE A 108
 None
 0.97A 1hshB-3vnpA:
undetectable		 1hshB-3vnpA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 3vnp HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		5 / 12 ALA A 112
ILE A  96
GLY A  97
GLY A 115
ILE A 126
 None
 0.76A 1hxbA-3vnpA:
undetectable		 1hxbA-3vnpA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 3vnp HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		5 / 12 ILE A  30
LEU A  63
GLY A  31
ASN A  53
ASP A  75
 None
 1.17A 1likA-3vnpA:
undetectable		 1likA-3vnpA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 3vnp HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		5 / 11 ALA A 112
ILE A  96
GLY A  97
GLY A 115
ILE A 126
 None
 0.79A 1sduA-3vnpA:
undetectable		 1sduA-3vnpA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 3vnp HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		5 / 10 ALA A 112
ILE A  96
GLY A  97
GLY A 115
ILE A 126
 None
 0.84A 1sdvA-3vnpA:
undetectable		 1sdvA-3vnpA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3vnp HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		5 / 12 ILE A 114
ALA A 112
ARG A 155
LEU A  85
ILE A  73
 None
 1.18A 1y0xX-3vnpA:
undetectable		 1y0xX-3vnpA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 3vnp HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		3 / 3 THR A   9
THR A  25
PRO A   4
 None
 0.88A 209dC-3vnpA:
undetectable		 209dC-3vnpA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3vnp HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		5 / 11 LEU A  63
LEU A  85
ILE A  30
THR A  34
ASN A  53
 None
 1.16A 2ft9A-3vnpA:
undetectable		 2ft9A-3vnpA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 3vnp HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		4 / 6 LEU A  95
LEU A 143
MET A 151
GLU A 150
 None
 1.08A 2kuhA-3vnpA:
undetectable		 2kuhA-3vnpA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 3vnp HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		3 / 3 GLU A 157
ARG A 153
GLN A  58
 None
 0.96A 4rtbA-3vnpA:
undetectable		 4rtbA-3vnpA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 3vnp HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		4 / 4 VAL A  55
GLY A  76
ARG A  54
VAL A 159
 None
 1.45A 5d4nA-3vnpA:
undetectable
5d4nB-3vnpA:
undetectable		 5d4nA-3vnpA:
20.11
5d4nB-3vnpA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3vnp HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		4 / 6 GLY A  26
THR A  25
VAL A  28
HIS A  64
 None
None
None
MG  A 202 (-3.4A)
 0.99A 5ewuA-3vnpA:
undetectable		 5ewuA-3vnpA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3vnp HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		4 / 6 GLY A  26
THR A  25
VAL A  28
HIS A  64
 None
None
None
MG  A 202 (-3.4A)
 1.08A 5ewuB-3vnpA:
undetectable		 5ewuB-3vnpA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 3vnp HYPOTHETICAL
CONSERVED PROTEIN
(Geobacillus
kaustophilus) 		4 / 6 SER A 118
ALA A 132
THR A 130
ALA A  94
 None
 1.00A 6ma6A-3vnpA:
undetectable		 6ma6A-3vnpA:
17.82