SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 12 THR A 399
TYR A 307
TYR A 413
GLY A 415
ALA A 417
 None
AMP  A 601 (-4.9A)
AMP  A 601 (-3.4A)
None
None
 1.31A 1httC-3vnsA:
2.8		 1httC-3vnsA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 12 THR A 399
TYR A 307
TYR A 413
GLY A 415
ALA A 417
 None
AMP  A 601 (-4.9A)
AMP  A 601 (-3.4A)
None
None
 1.28A 1httD-3vnsA:
2.7		 1httD-3vnsA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 9 PRO A 354
GLU A 405
GLY A 355
GLY A 409
ASP A 408
 None
 0.97A 1mxdA-3vnsA:
undetectable		 1mxdA-3vnsA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 11 PRO A 354
GLU A 405
GLY A 355
GLY A 409
ASP A 408
 None
 0.94A 1mxgA-3vnsA:
undetectable		 1mxgA-3vnsA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 7 GLY A 281
THR A 317
ILE A 333
GLY A 306
 AMP  A 601 ( 3.4A)
None
None
AMP  A 601 (-4.7A)
 0.80A 1usqF-3vnsA:
undetectable		 1usqF-3vnsA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 6 TYR A  92
GLY A 216
PHE A 218
SER A 219
 None
 0.85A 2a3cA-3vnsA:
undetectable		 2a3cA-3vnsA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 6 TYR A  92
GLY A 216
PHE A 218
SER A 219
 None
 0.83A 2a3cB-3vnsA:
undetectable		 2a3cB-3vnsA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 6 ALA A 217
TYR A  43
TRP A 215
ILE A 214
 None
 0.98A 2dcfA-3vnsA:
undetectable		 2dcfA-3vnsA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 7 GLY A 281
THR A 317
ILE A 333
GLY A 306
 AMP  A 601 ( 3.4A)
None
None
AMP  A 601 (-4.7A)
 0.80A 2jkjE-3vnsA:
undetectable		 2jkjE-3vnsA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 7 GLY A 281
THR A 317
ILE A 333
GLY A 306
 AMP  A 601 ( 3.4A)
None
None
AMP  A 601 (-4.7A)
 0.78A 2jklE-3vnsA:
undetectable		 2jklE-3vnsA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 5 PHE A 318
PHE A 315
PHE A 209
VAL A 304
 None
DVA  A 602 (-3.7A)
DVA  A 602 ( 4.2A)
None
 1.22A 2lh6A-3vnsA:
undetectable		 2lh6A-3vnsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 9 GLU A 320
VAL A 190
GLY A 306
PHE A 279
ILE A 278
 None
None
AMP  A 601 (-4.7A)
None
None
 1.45A 2w98A-3vnsA:
4.3		 2w98A-3vnsA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 7 ALA A 217
TYR A  43
TRP A 215
ILE A 214
 None
 0.99A 2zm7A-3vnsA:
undetectable		 2zm7A-3vnsA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 8 ALA A 217
TYR A  43
TRP A 215
ILE A 214
 None
 0.97A 2zm8A-3vnsA:
undetectable		 2zm8A-3vnsA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 8 ALA A 217
TYR A  43
TRP A 215
ILE A 214
 None
 0.98A 2zmaA-3vnsA:
undetectable		 2zmaA-3vnsA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 5 VAL A 344
VAL A 345
THR A 342
ARG A 343
 None
 1.22A 3bjwA-3vnsA:
undetectable		 3bjwA-3vnsA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 12 GLY A 216
ILE A  82
LEU A  86
LEU A  34
LEU A 201
 None
 1.26A 3cs8A-3vnsA:
undetectable		 3cs8A-3vnsA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 12 GLY A  89
GLY A  65
ASP A  16
VAL A  18
ARG A  63
 None
 1.34A 3dlcA-3vnsA:
undetectable		 3dlcA-3vnsA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		3 / 3 ASN A 479
HIS A 480
VAL A 437
 None
 0.78A 3elzB-3vnsA:
undetectable		 3elzB-3vnsA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 7 GLY A 355
PHE A 340
PHE A 411
GLY A 409
 None
 0.92A 3ko0M-3vnsA:
undetectable
3ko0P-3vnsA:
undetectable		 3ko0M-3vnsA:
10.42
3ko0P-3vnsA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 8 GLY A 355
PHE A 340
PHE A 411
GLY A 409
 None
 0.99A 3ko0O-3vnsA:
undetectable
3ko0Q-3vnsA:
undetectable		 3ko0O-3vnsA:
10.42
3ko0Q-3vnsA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		3 / 3 ASP A 401
GLU A 311
SER A 331
 AMP  A 601 (-2.7A)
None
None
 0.77A 3p2kA-3vnsA:
undetectable		 3p2kA-3vnsA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 12 TYR A 307
ALA A 330
ASN A 305
LEU A 303
TYR A 325
 AMP  A 601 (-4.9A)
None
AMP  A 601 (-3.6A)
None
None
 1.20A 3qxyA-3vnsA:
undetectable		 3qxyA-3vnsA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 10 PHE A 191
GLY A 216
PHE A 209
PHE A 315
PHE A 318
 None
None
DVA  A 602 ( 4.2A)
DVA  A 602 (-3.7A)
None
 1.39A 3r6wA-3vnsA:
undetectable
3r6wB-3vnsA:
2.1		 3r6wA-3vnsA:
19.19
3r6wB-3vnsA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 11 TYR A 307
ALA A 330
ASN A 305
LEU A 303
TYR A 325
 AMP  A 601 (-4.9A)
None
AMP  A 601 (-3.6A)
None
None
 1.19A 3rc0A-3vnsA:
undetectable		 3rc0A-3vnsA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 12 TYR A 307
ALA A 330
ASN A 305
LEU A 303
TYR A 325
 AMP  A 601 (-4.9A)
None
AMP  A 601 (-3.6A)
None
None
 1.18A 3rc0B-3vnsA:
undetectable		 3rc0B-3vnsA:
22.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 7 PHE A 207
ASP A 208
GLY A 280
THR A 310
 DVA  A 602 (-4.1A)
DVA  A 602 (-2.8A)
DVA  A 602 ( 4.1A)
AMP  A 601 (-3.9A)
 0.83A 3vnsA-3vnsA:
74.1		 3vnsA-3vnsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		7 / 7 PHE A 207
ASP A 208
PHE A 209
GLY A 281
THR A 310
PHE A 315
LYS A 507
 DVA  A 602 (-4.1A)
DVA  A 602 (-2.8A)
DVA  A 602 ( 4.2A)
AMP  A 601 ( 3.4A)
AMP  A 601 (-3.9A)
DVA  A 602 (-3.7A)
DVA  A 602 ( 2.7A)
 0.00A 3vnsA-3vnsA:
74.1		 3vnsA-3vnsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 12 ASP A   9
LEU A  20
GLY A 221
SER A 194
ARG A 275
 None
 1.31A 4djeA-3vnsA:
undetectable		 4djeA-3vnsA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		3 / 3 LYS A 381
ARG A 398
TRP A 361
 None
 1.48A 4i90A-3vnsA:
undetectable		 4i90A-3vnsA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 12 PHE A 202
GLU A 213
THR A 253
GLU A 282
GLY A 506
 None
 1.19A 4q15B-3vnsA:
undetectable		 4q15B-3vnsA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 8 ARG A 290
ALA A 286
LEU A 289
PHE A 207
 None
None
None
DVA  A 602 (-4.1A)
 1.02A 4rkuA-3vnsA:
undetectable
4rkuJ-3vnsA:
undetectable		 4rkuA-3vnsA:
23.35
4rkuJ-3vnsA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 7 GLU A 320
LEU A 303
LEU A 289
ARG A 290
 None
 0.80A 4wg0B-3vnsA:
undetectable
4wg0C-3vnsA:
undetectable		 4wg0B-3vnsA:
2.70
4wg0C-3vnsA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		3 / 3 ARG A 198
ASP A 197
ARG A 275
 None
 0.70A 4wq4B-3vnsA:
undetectable		 4wq4B-3vnsA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 7 PHE A 207
ASP A 208
GLY A 280
THR A 310
 DVA  A 602 (-4.1A)
DVA  A 602 (-2.8A)
DVA  A 602 ( 4.1A)
AMP  A 601 (-3.9A)
 1.05A 4zxiA-3vnsA:
46.1		 4zxiA-3vnsA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 7 PHE A 207
ASP A 208
GLY A 281
THR A 310
LYS A 507
 DVA  A 602 (-4.1A)
DVA  A 602 (-2.8A)
AMP  A 601 ( 3.4A)
AMP  A 601 (-3.9A)
DVA  A 602 ( 2.7A)
 0.56A 4zxiA-3vnsA:
46.1		 4zxiA-3vnsA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 11 THR A 399
TYR A 307
TYR A 413
GLY A 415
ALA A 417
 None
AMP  A 601 (-4.9A)
AMP  A 601 (-3.4A)
None
None
 1.34A 5e3iB-3vnsA:
undetectable		 5e3iB-3vnsA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 5 ASP A 432
THR A 435
ARG A 439
GLU A 414
 None
 1.00A 5k9dA-3vnsA:
undetectable		 5k9dA-3vnsA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 12 GLY A 281
TYR A 307
ASN A 305
TYR A 325
LEU A 289
 AMP  A 601 ( 3.4A)
AMP  A 601 (-4.9A)
AMP  A 601 (-3.6A)
None
None
 1.42A 5kklB-3vnsA:
undetectable		 5kklB-3vnsA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 12 GLY A 281
TYR A 413
ASN A 305
TYR A 325
LEU A 289
 AMP  A 601 ( 3.4A)
AMP  A 601 (-3.4A)
AMP  A 601 (-3.6A)
None
None
 1.26A 5kklB-3vnsA:
undetectable		 5kklB-3vnsA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 5 LEU A 183
PHE A 191
LEU A 337
TRP A 212
 None
 1.34A 5m10A-3vnsA:
undetectable		 5m10A-3vnsA:
24.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		6 / 7 PHE A 207
ASP A 208
PHE A 209
GLY A 281
GLY A 308
LYS A 507
 DVA  A 602 (-4.1A)
DVA  A 602 (-2.8A)
DVA  A 602 ( 4.2A)
AMP  A 601 ( 3.4A)
DVA  A 602 ( 4.2A)
DVA  A 602 ( 2.7A)
 0.47A 5n9xA-3vnsA:
59.3		 5n9xA-3vnsA:
56.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		5 / 12 ALA A 217
LEU A 184
ILE A  11
VAL A  24
ASP A  16
 None
 1.21A 5vlmG-3vnsA:
undetectable		 5vlmG-3vnsA:
16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WM7_A_ACTA603_0
(SALICYLATE-AMP
LIGASE)		 3vns NRPS ADENYLATION
PROTEIN CYTC1
(Streptomyces
sp.) 		4 / 4 THR A 253
THR A 255
ALA A 256
ARG A 502
 None
 1.28A 5wm7A-3vnsA:
41.6		 5wm7A-3vnsA:
35.73