SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3voc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		3 / 3 ALA A  50
VAL A  47
TRP A  44
 None
 0.87A 1c4dC-3vocA:
undetectable
1c4dD-3vocA:
undetectable		 1c4dC-3vocA:
9.52
1c4dD-3vocA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		3 / 3 GLN A 132
ILE A 276
HIS A 265
 CA  A 501 (-2.9A)
None
EDO  A 505 ( 4.2A)
 0.75A 1fm9A-3vocA:
undetectable		 1fm9A-3vocA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		5 / 11 ALA A 121
GLY A 130
GLY A 158
HIS A 256
VAL A 259
 None
 1.02A 1pg2A-3vocA:
undetectable		 1pg2A-3vocA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 8 MET A  11
THR A  39
ALA A  37
VAL A  75
 None
 0.82A 1sn5C-3vocA:
undetectable		 1sn5C-3vocA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 6 SER A 161
ARG A 165
TYR A 170
TYR A 169
 None
 1.41A 1tufA-3vocA:
5.2
1tufB-3vocA:
7.2		 1tufA-3vocA:
21.88
1tufB-3vocA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 8 TYR A 169
CYH A 323
TRP A 285
LEU A 341
 None
 1.37A 1uw6A-3vocA:
undetectable
1uw6B-3vocA:
undetectable		 1uw6A-3vocA:
19.40
1uw6B-3vocA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 8 TYR A 169
CYH A 323
TRP A 285
LEU A 341
 None
 1.33A 1uw6D-3vocA:
undetectable
1uw6E-3vocA:
undetectable		 1uw6D-3vocA:
19.40
1uw6E-3vocA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 8 TYR A 169
CYH A 323
TRP A 285
LEU A 341
 None
 1.33A 1uw6G-3vocA:
undetectable
1uw6H-3vocA:
undetectable		 1uw6G-3vocA:
19.40
1uw6H-3vocA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 8 TYR A 169
CYH A 323
TRP A 285
LEU A 341
 None
 1.35A 1uw6P-3vocA:
undetectable
1uw6Q-3vocA:
undetectable		 1uw6P-3vocA:
19.40
1uw6Q-3vocA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 8 TRP A 285
LEU A 341
TYR A 169
CYH A 323
 None
 1.31A 1uw6P-3vocA:
undetectable
1uw6T-3vocA:
undetectable		 1uw6P-3vocA:
19.40
1uw6T-3vocA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 5 LEU A 324
GLY A 358
ILE A 376
PHE A 379
 None
 0.94A 1xf1A-3vocA:
1.4		 1xf1A-3vocA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 5 PRO A 225
GLY A 230
ASN A 234
GLY A 236
 None
 1.08A 1zlqA-3vocA:
undetectable		 1zlqA-3vocA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		5 / 12 ALA A 264
ALA A 315
LEU A 317
LEU A 164
HIS A 256
 None
 1.12A 2h77A-3vocA:
undetectable		 2h77A-3vocA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 8 LEU A 308
LEU A 283
PRO A 124
GLY A 159
 None
 0.94A 2po5B-3vocA:
undetectable		 2po5B-3vocA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		9 / 12 GLU A 163
ARG A 165
TYR A 169
TRP A 175
SER A 281
GLY A 282
HIS A 284
THR A 322
MET A 326
 None
None
None
None
None
None
GOL  A 508 ( 4.7A)
None
None
 0.58A 2xffA-3vocA:
42.5		 2xffA-3vocA:
31.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 7 PRO A 124
ILE A 260
PRO A 160
GLY A 159
 None
 0.94A 2y7kA-3vocA:
undetectable		 2y7kA-3vocA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		5 / 12 HIS A  81
SER A  79
THR A  80
GLY A 159
LEU A 156
 None
 1.14A 3fzgA-3vocA:
undetectable		 3fzgA-3vocA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		5 / 12 HIS A  81
SER A  79
THR A  80
GLY A 162
LEU A 156
 None
 1.26A 3fzgA-3vocA:
undetectable		 3fzgA-3vocA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 7 LEU A 308
ARG A 165
PRO A 124
GLY A 159
 None
 0.86A 3hcrB-3vocA:
undetectable		 3hcrB-3vocA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		5 / 12 ARG A 180
GLY A 181
GLY A 300
GLU A 113
ASN A 118
 None
 1.05A 3kkzB-3vocA:
undetectable		 3kkzB-3vocA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 8 ILE A  93
SER A  49
SER A  97
GLY A  45
 None
 0.93A 3lslA-3vocA:
undetectable
3lslD-3vocA:
undetectable		 3lslA-3vocA:
22.68
3lslD-3vocA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		5 / 10 PHE A 140
VAL A  47
ILE A  78
THR A  40
PHE A 144
 None
 1.26A 3t3rD-3vocA:
undetectable		 3t3rD-3vocA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		5 / 11 LEU A 324
THR A 322
GLU A 325
VAL A  10
PHE A 406
 None
 1.30A 3tbgA-3vocA:
undetectable		 3tbgA-3vocA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 8 VAL A  47
TYR A  59
TRP A  20
TYR A 147
 None
 1.05A 3v81A-3vocA:
undetectable		 3v81A-3vocA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		5 / 12 TYR A 137
ILE A 260
ALA A 264
PHE A 312
LEU A 317
 None
 1.49A 3vw1B-3vocA:
undetectable		 3vw1B-3vocA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 4 PRO A  96
LEU A 122
HIS A 256
LEU A 257
 None
 1.30A 3vw7A-3vocA:
undetectable		 3vw7A-3vocA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 5 GLY A 181
TYR A 170
TYR A 169
GLU A 120
 None
 1.04A 4ae1B-3vocA:
undetectable		 4ae1B-3vocA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		5 / 12 TYR A  60
TYR A  63
ILE A 154
ALA A  64
ILE A  78
 None
 1.11A 4rvdA-3vocA:
undetectable		 4rvdA-3vocA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 6 SER A 204
LEU A 205
ASP A 206
LEU A 219
 None
GOL  A 506 (-4.6A)
GOL  A 506 (-2.9A)
None
 0.78A 4wozA-3vocA:
11.1
4wozB-3vocA:
10.6		 4wozA-3vocA:
24.52
4wozB-3vocA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		5 / 11 ILE A  77
THR A 385
ASP A  41
GLU A 359
GLU A 163
 None
 1.23A 4xt7A-3vocA:
undetectable		 4xt7A-3vocA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 7 LEU A  95
GLY A 159
GLY A 158
ILE A 260
 None
 0.61A 4yjiA-3vocA:
undetectable		 4yjiA-3vocA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 6 SER A   9
GLY A 358
ASN A 357
ILE A 410
 None
 1.07A 5j4nA-3vocA:
undetectable		 5j4nA-3vocA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		3 / 3 ARG A 165
PRO A 160
ASN A 118
 None
 0.82A 5jwaA-3vocA:
undetectable
5jwaH-3vocA:
undetectable		 5jwaA-3vocA:
21.65
5jwaH-3vocA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 7 ILE A 222
PHE A 194
LYS A 201
SER A 251
 None
 1.23A 5nr3A-3vocA:
undetectable		 5nr3A-3vocA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		3 / 3 LEU A 356
VAL A 342
ASP A 343
 None
None
TRS  A 509 ( 3.0A)
 0.45A 5x23A-3vocA:
undetectable		 5x23A-3vocA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		3 / 3 GLN A 132
ILE A 276
HIS A 265
 CA  A 501 (-2.9A)
None
EDO  A 505 ( 4.2A)
 0.71A 5z12B-3vocA:
undetectable		 5z12B-3vocA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		4 / 5 LYS A 352
GLN A 310
GLY A 301
ILE A 280
 None
 1.33A 6debB-3vocA:
undetectable		 6debB-3vocA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 3voc BETA/ALPHA-AMYLASE
(Paenibacillus
polymyxa) 		5 / 11 GLU A 120
SER A 168
ALA A 299
THR A 296
LEU A 341
 None
 1.46A 6efnA-3vocA:
7.4		 6efnA-3vocA:
22.36