SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3von'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 3von UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
2
(Homo
sapiens) 		3 / 3 GLU B 121
LYS B 108
VAL B 105
 None
 0.89A 1l2iA-3vonB:
undetectable		 1l2iA-3vonB:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3von UBIQUITIN
THIOESTERASE OTUB1
(Homo
sapiens) 		4 / 5 SER A 180
PHE A 130
VAL A 200
PHE A 203
 None
 1.30A 1oipA-3vonA:
undetectable		 1oipA-3vonA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3von UBIQUITIN
THIOESTERASE OTUB1
(Homo
sapiens) 		5 / 12 PHE A  92
GLY A 264
ILE A 231
LEU A 223
ASN A  90
 None
 1.11A 3eeoA-3vonA:
undetectable		 3eeoA-3vonA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3von UBIQUITIN
THIOESTERASE OTUB1
(Homo
sapiens) 		4 / 7 TYR A 235
VAL A  56
ILE A  72
ARG A  83
 None
 1.18A 3ik3A-3vonA:
undetectable		 3ik3A-3vonA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3von UBIQUITIN
THIOESTERASE OTUB1
(Homo
sapiens) 		3 / 3 HIS A 265
SER A 215
GLU A 214
 None
 0.89A 3s8pA-3vonA:
undetectable		 3s8pA-3vonA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3von UBIQUITIN
THIOESTERASE OTUB1
(Homo
sapiens) 		5 / 12 VAL A 257
ALA A 103
LEU A 101
PHE A 114
LEU A 223
 None
 1.20A 4eckA-3vonA:
undetectable		 4eckA-3vonA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3von UBIQUITIN
THIOESTERASE OTUB1
(Homo
sapiens) 		3 / 3 PHE A  98
VAL A 229
ILE A 231
 None
 0.64A 4emaA-3vonA:
undetectable		 4emaA-3vonA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_G_AZMG402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 3von UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
2
(Homo
sapiens) 		5 / 12 GLU B  18
VAL B  80
LEU B  65
VAL B  67
LEU B 119
 None
 0.91A 4xiwG-3vonB:
undetectable		 4xiwG-3vonB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 3von UBIQUITIN
THIOESTERASE OTUB1
(Homo
sapiens) 		4 / 8 TYR A  79
LYS A  78
PRO A 255
ILE A 231
 None
 0.99A 5jhdE-3vonA:
undetectable
5jhdG-3vonA:
undetectable		 5jhdE-3vonA:
22.61
5jhdG-3vonA:
19.11