SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3voo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		3 / 3 TRP A 326
PHE A 347
TRP A 340
 None
 1.46A 1r15C-3vooA:
undetectable		 1r15C-3vooA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		3 / 3 TRP A 326
PHE A 347
TRP A 340
 None
 1.45A 1r15F-3vooA:
undetectable		 1r15F-3vooA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		3 / 3 TRP A 326
PHE A 347
TRP A 340
 None
 1.45A 1r15G-3vooA:
undetectable		 1r15G-3vooA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		3 / 3 TRP A 326
PHE A 347
TRP A 340
 None
 1.46A 1r15H-3vooA:
undetectable		 1r15H-3vooA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		5 / 12 GLY A  82
GLY A  81
LYS A 194
ILE A 197
SER A 228
 None
 0.99A 1v2xA-3vooA:
undetectable		 1v2xA-3vooA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		3 / 3 PHE A 252
TYR A  21
TYR A 317
 None
 1.02A 1x70B-3vooA:
undetectable		 1x70B-3vooA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		5 / 11 GLU A 235
GLY A  79
ILE A 197
LEU A 236
ALA A 193
 None
 0.92A 1x7pA-3vooA:
undetectable
1x7pB-3vooA:
undetectable		 1x7pA-3vooA:
23.21
1x7pB-3vooA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		3 / 3 LEU A  31
PHE A  36
ARG A  22
 None
 0.74A 1xdkF-3vooA:
undetectable		 1xdkF-3vooA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		5 / 10 PHE A 133
ALA A 254
LEU A 257
LEU A 378
LEU A 401
 None
 1.13A 2bxqA-3vooA:
2.3		 2bxqA-3vooA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		5 / 12 ILE A 200
ILE A 197
TRP A 192
VAL A 239
VAL A 237
 None
None
None
HEM  A 501 ( 3.9A)
None
 1.13A 2ygpA-3vooA:
undetectable		 2ygpA-3vooA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		6 / 11 GLY A  81
ILE A 197
LEU A 236
VAL A 234
ARG A 186
ALA A 233
 None
 1.39A 3dcmX-3vooA:
undetectable		 3dcmX-3vooA:
18.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		4 / 5 LEU A  77
PHE A 169
ARG A 241
PRO A 242
 None
None
None
HEM  A 501 (-4.2A)
 0.29A 3vm4A-3vooA:
69.3		 3vm4A-3vooA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		3 / 3 PHE A 332
ASP A 328
ARG A 336
 None
 0.88A 4eahF-3vooA:
undetectable		 4eahF-3vooA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		3 / 3 PHE A 332
ASP A 328
ARG A 336
 None
 0.87A 4eahG-3vooA:
undetectable		 4eahG-3vooA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		5 / 10 LEU A 153
GLU A 117
ARG A 120
GLY A 163
LEU A 165
 None
 1.34A 5dxbA-3vooA:
undetectable		 5dxbA-3vooA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		5 / 12 ILE A 263
TYR A 273
GLU A 331
PHE A 284
TYR A 285
 None
 1.34A 5igwA-3vooA:
undetectable		 5igwA-3vooA:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		4 / 8 LEU A  77
ARG A 241
PRO A 242
PHE A 287
 None
None
HEM  A 501 (-4.2A)
HEM  A 501 (-3.7A)
 0.51A 5m0oC-3vooA:
54.5		 5m0oC-3vooA:
37.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		5 / 12 GLY A  50
GLY A 318
ASN A  34
PHE A 347
THR A 325
 None
 1.37A 5yf0A-3vooA:
undetectable		 5yf0A-3vooA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		4 / 7 PHE A  98
LEU A 240
ALA A 149
THR A 211
 HEM  A 501 (-3.7A)
None
None
None
 0.89A 6a7jA-3vooA:
32.0		 6a7jA-3vooA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 3voo FATTY ACID
ALPHA-HYDROXYLASE
(Sphingomonas
paucimobilis) 		5 / 12 ARG A 186
GLY A 199
ALA A 193
ALA A 233
VAL A 234
 None
 1.01A 6c2mC-3vooA:
undetectable		 6c2mC-3vooA:
11.52