SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vot'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		4 / 5 GLY A 268
LEU A 211
THR A 210
VAL A 313
 None
 1.10A 1ekjF-3votA:
undetectable
1ekjG-3votA:
undetectable		 1ekjF-3votA:
19.20
1ekjG-3votA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		4 / 6 TYR A 339
TYR A 404
HIS A 394
VAL A 358
 None
 1.35A 1q13A-3votA:
undetectable		 1q13A-3votA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		5 / 12 GLY A 264
ALA A 262
ILE A 119
PHE A 104
ALA A 289
 None
 1.20A 1vq1A-3votA:
undetectable		 1vq1A-3votA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		5 / 10 TYR A 224
TYR A 238
ILE A 252
GLU A 273
ILE A 208
 None
None
None
CA  A 503 ( 2.6A)
None
 1.21A 2dm6A-3votA:
5.1
2dm6B-3votA:
5.0		 2dm6A-3votA:
20.70
2dm6B-3votA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		4 / 6 PHE A 368
PHE A 370
GLY A 295
GLY A 293
 None
 1.01A 2qr2A-3votA:
undetectable
2qr2B-3votA:
undetectable		 2qr2A-3votA:
20.38
2qr2B-3votA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		5 / 12 ALA A   9
ALA A  47
GLY A  43
VAL A  66
THR A  70
 None
 1.13A 3c6gB-3votA:
undetectable		 3c6gB-3votA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		5 / 9 GLN A 344
LEU A 355
VAL A 358
TYR A 339
ILE A 341
 None
 1.27A 3claA-3votA:
undetectable		 3claA-3votA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		5 / 10 ILE A 307
SER A 304
LYS A 302
GLY A 306
LEU A 312
 None
 1.36A 3ik6B-3votA:
undetectable
3ik6E-3votA:
undetectable		 3ik6B-3votA:
20.41
3ik6E-3votA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		5 / 10 SER A 304
LYS A 302
GLY A 306
SER A 221
LEU A 312
 None
 1.15A 3ik6B-3votA:
undetectable
3ik6E-3votA:
undetectable		 3ik6B-3votA:
20.41
3ik6E-3votA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		5 / 11 SER A 304
LYS A 302
GLY A 306
SER A 221
LEU A 312
 None
 1.08A 3iluB-3votA:
undetectable
3iluE-3votA:
undetectable		 3iluB-3votA:
20.41
3iluE-3votA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		5 / 12 HIS A 271
LEU A 220
SER A 297
PHE A 309
GLY A 268
 None
 0.98A 3kk6B-3votA:
undetectable		 3kk6B-3votA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		5 / 12 HIS A 271
VAL A 219
LEU A 220
SER A 297
PHE A 309
 None
 1.25A 3kk6B-3votA:
undetectable		 3kk6B-3votA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		5 / 12 PHE A 368
PHE A 309
GLY A 268
ALA A 270
THR A 272
 None
 1.44A 3ld6B-3votA:
undetectable		 3ld6B-3votA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		4 / 6 ILE A  10
ALA A   9
ALA A  93
THR A  90
 None
 0.81A 3mdrB-3votA:
undetectable		 3mdrB-3votA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		4 / 5 PHE A 326
ILE A 307
GLY A 328
HIS A 218
 None
 1.23A 3r0lD-3votA:
undetectable		 3r0lD-3votA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		4 / 8 LEU A 144
VAL A 129
LEU A 170
TYR A 146
 None
 1.09A 3v81A-3votA:
undetectable		 3v81A-3votA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		4 / 6 GLY A 388
ILE A 352
GLN A 369
VAL A 367
 None
 1.07A 4d39B-3votA:
undetectable		 4d39B-3votA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		4 / 7 LEU A  97
ALA A  93
LEU A  99
THR A  90
 None
 0.88A 4d7bA-3votA:
undetectable		 4d7bA-3votA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		4 / 6 PHE A  76
ALA A   9
ALA A  94
THR A  90
 None
 1.00A 4dtzA-3votA:
undetectable		 4dtzA-3votA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		4 / 7 LEU A  97
ALA A  93
LEU A  99
THR A  90
 None
 0.97A 4ikjA-3votA:
undetectable
4ikjB-3votA:
undetectable		 4ikjA-3votA:
14.52
4ikjB-3votA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		4 / 7 LEU A  97
ALA A  93
LEU A  99
THR A  90
 None
 0.93A 4ikkA-3votA:
undetectable
4ikkB-3votA:
undetectable		 4ikkA-3votA:
14.52
4ikkB-3votA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		3 / 3 ARG A   4
LYS A   2
LYS A 319
 None
 1.18A 4k50A-3votA:
undetectable		 4k50A-3votA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		3 / 3 ARG A   4
LYS A   2
LYS A 319
 None
 1.13A 4k50I-3votA:
undetectable		 4k50I-3votA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		5 / 12 PHE A  89
LEU A  54
GLY A 101
LEU A  97
PHE A  76
 None
 1.11A 4kykA-3votA:
undetectable
4kykB-3votA:
undetectable		 4kykA-3votA:
17.10
4kykB-3votA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		5 / 10 THR A 272
ALA A 251
VAL A 219
GLY A 258
THR A 257
 None
 0.96A 4qvyK-3votA:
undetectable
4qvyL-3votA:
undetectable		 4qvyK-3votA:
20.19
4qvyL-3votA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		5 / 10 THR A 272
ALA A 251
VAL A 219
GLY A 258
THR A 257
 None
 0.96A 4qvyY-3votA:
undetectable
4qvyZ-3votA:
undetectable		 4qvyY-3votA:
20.19
4qvyZ-3votA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		3 / 5 GLY A 226
GLY A 236
GLU A 235
 None
None
CA  A 502 ( 4.4A)
 0.50A 4z2eA-3votA:
2.3
4z2eD-3votA:
2.6		 4z2eA-3votA:
21.03
4z2eD-3votA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		3 / 5 GLY A 236
GLY A 226
GLU A 205
 None
None
ADP  A 501 ( 2.7A)
 0.46A 4z2eA-3votA:
2.3
4z2eD-3votA:
2.6		 4z2eA-3votA:
21.03
4z2eD-3votA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		4 / 8 ILE A  10
LEU A   8
ILE A  20
LEU A  82
 None
 0.66A 4zvcA-3votA:
undetectable
4zvcB-3votA:
undetectable		 4zvcA-3votA:
13.85
4zvcB-3votA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		4 / 8 ILE A  20
LEU A  82
ILE A  10
LEU A   8
 None
 0.66A 4zvcA-3votA:
undetectable
4zvcB-3votA:
undetectable		 4zvcA-3votA:
13.85
4zvcB-3votA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		4 / 8 LEU A  56
ILE A  11
LEU A  54
MET A  64
 None
 0.83A 5g48A-3votA:
undetectable		 5g48A-3votA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		5 / 12 VAL A 287
ALA A 270
ILE A 208
THR A 210
GLY A 258
 None
 0.75A 5hieA-3votA:
undetectable		 5hieA-3votA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		5 / 12 VAL A 287
ALA A 270
ILE A 208
THR A 210
GLY A 258
 None
 0.74A 5hieB-3votA:
2.1		 5hieB-3votA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3vot L-AMINO ACID LIGASE,
BL00235
(Bacillus
licheniformis) 		5 / 12 VAL A 287
ALA A 270
ILE A 208
THR A 210
GLY A 258
 None
 0.74A 5hieD-3votA:
undetectable		 5hieD-3votA:
20.87