SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vpo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		5 / 12 HIS A 172
PHE A 236
PHE A 240
GLY A 267
HIS A 269
 None
None
None
None
FE  A 402 (-3.3A)
 1.28A 1a4lD-3vpoA:
undetectable		 1a4lD-3vpoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		4 / 8 GLY A 238
SER A 242
PHE A 133
PHE A 134
 None
 0.90A 1ax9A-3vpoA:
undetectable		 1ax9A-3vpoA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		7 / 11 ASP A 138
GLU A 169
HIS A 172
GLU A 232
PHE A 240
ILE A 262
GLU A 266
 None
FE  A 402 (-2.6A)
None
FE  A 402 (-2.8A)
None
None
FE  A 402 (-1.8A)
 0.50A 1rnrA-3vpoA:
31.1		 1rnrA-3vpoA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		7 / 11 ASP A 138
HIS A 172
GLU A 232
SER A 239
PHE A 240
ILE A 262
GLU A 266
 None
None
FE  A 402 (-2.8A)
None
None
None
FE  A 402 (-1.8A)
 0.77A 1rnrA-3vpoA:
31.1		 1rnrA-3vpoA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		7 / 12 ASP A 138
GLU A 169
HIS A 172
GLU A 232
PHE A 240
ILE A 262
GLU A 266
 None
FE  A 402 (-2.6A)
None
FE  A 402 (-2.8A)
None
None
FE  A 402 (-1.8A)
 0.43A 1rnrB-3vpoA:
31.1		 1rnrB-3vpoA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		7 / 12 ASP A 138
GLU A 169
HIS A 172
TYR A 176
GLU A 232
ILE A 262
GLU A 266
 None
FE  A 402 (-2.6A)
None
None
FE  A 402 (-2.8A)
None
FE  A 402 (-1.8A)
 0.67A 1rnrB-3vpoA:
31.1		 1rnrB-3vpoA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		4 / 6 LEU A 131
PHE A 134
ALA A 135
LEU A 179
 None
 0.88A 1ukbA-3vpoA:
undetectable		 1ukbA-3vpoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		5 / 10 ALA A 230
PHE A 228
TRP A 213
ALA A 210
LEU A 211
 None
 1.07A 2bxqA-3vpoA:
undetectable		 2bxqA-3vpoA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		4 / 7 MET A  93
ILE A 155
VAL A 153
TYR A 221
 None
 0.87A 3p6hA-3vpoA:
undetectable		 3p6hA-3vpoA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		3 / 3 LEU A 275
HIS A 279
MET A 276
 None
 0.96A 3thrD-3vpoA:
undetectable		 3thrD-3vpoA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		5 / 12 PHE A 244
SER A 258
HIS A 172
TYR A 176
LEU A 131
 None
 1.19A 3vn2A-3vpoA:
2.5		 3vn2A-3vpoA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		4 / 6 HIS A 269
GLU A 232
LEU A 145
ASP A 138
 FE  A 402 (-3.3A)
FE  A 402 (-2.8A)
None
None
 1.41A 4cevA-3vpoA:
undetectable
4cevB-3vpoA:
undetectable		 4cevA-3vpoA:
22.85
4cevB-3vpoA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		4 / 5 GLY A 222
ARG A 224
GLU A 152
PHE A 149
 None
 1.03A 4r82A-3vpoA:
undetectable
4r82B-3vpoA:
undetectable		 4r82A-3vpoA:
18.62
4r82B-3vpoA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		4 / 6 PHE A  83
PRO A  84
THR A 156
ILE A  85
 None
None
MG  A 401 (-2.9A)
None
 1.35A 5ih0A-3vpoA:
undetectable		 5ih0A-3vpoA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		5 / 12 ILE A 140
GLY A 139
PHE A 134
PHE A 236
ALA A 210
 None
 1.22A 5n0rA-3vpoA:
undetectable		 5n0rA-3vpoA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		5 / 12 ILE A 140
GLY A 139
PHE A 134
PHE A 236
ALA A 210
 None
 1.24A 5n0xB-3vpoA:
undetectable		 5n0xB-3vpoA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		4 / 6 TYR A  94
ASP A  89
TRP A  91
HIS A  88
 None
 1.40A 5ov9A-3vpoA:
undetectable		 5ov9A-3vpoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		4 / 7 TYR A  94
ASP A  89
TRP A  91
HIS A  88
 None
 1.40A 5ov9B-3vpoA:
undetectable		 5ov9B-3vpoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		4 / 7 ILE A 313
LEU A 246
MET A 252
LEU A 255
 None
 0.93A 5u4sA-3vpoA:
undetectable		 5u4sA-3vpoA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		4 / 8 ILE A 313
LEU A 246
MET A 252
LEU A 255
 None
 0.92A 5u4sB-3vpoA:
undetectable		 5u4sB-3vpoA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		4 / 6 ASP A 138
GLN A 165
VAL A 141
ALA A 104
 None
FE  A 402 (-4.5A)
None
None
 1.12A 6djzB-3vpoA:
undetectable		 6djzB-3vpoA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens) 		3 / 3 TRP A 116
ILE A 127
GLU A 122
 None
 0.83A 6hcxA-3vpoA:
undetectable		 6hcxA-3vpoA:
14.39