SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vps'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		4 / 5 SER A 118
THR A 119
GLU A 151
GLY A 149
 None
UD1  A 400 (-3.0A)
None
None
 1.15A 1icrA-3vpsA:
undetectable
1icrB-3vpsA:
undetectable		 1icrA-3vpsA:
22.12
1icrB-3vpsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		4 / 5 GLU A 151
GLY A 149
SER A 118
THR A 119
 None
None
None
UD1  A 400 (-3.0A)
 1.15A 1icrA-3vpsA:
undetectable
1icrB-3vpsA:
undetectable		 1icrA-3vpsA:
22.12
1icrB-3vpsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		4 / 6 GLU A 151
GLY A 149
SER A 118
THR A 119
 None
None
None
UD1  A 400 (-3.0A)
 1.16A 1icuA-3vpsA:
undetectable
1icuB-3vpsA:
undetectable		 1icuA-3vpsA:
22.12
1icuB-3vpsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		4 / 6 SER A 118
THR A 119
GLU A 151
GLY A 149
 None
UD1  A 400 (-3.0A)
None
None
 1.16A 1icuC-3vpsA:
undetectable
1icuD-3vpsA:
undetectable		 1icuC-3vpsA:
22.12
1icuD-3vpsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		4 / 5 SER A 118
THR A 119
GLU A 151
GLY A 149
 None
UD1  A 400 (-3.0A)
None
None
 1.14A 1icvC-3vpsA:
undetectable
1icvD-3vpsA:
undetectable		 1icvC-3vpsA:
22.12
1icvD-3vpsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		4 / 5 GLU A 151
GLY A 149
SER A 118
THR A 119
 None
None
None
UD1  A 400 (-3.0A)
 1.14A 1icvC-3vpsA:
undetectable
1icvD-3vpsA:
undetectable		 1icvC-3vpsA:
22.12
1icvD-3vpsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		4 / 5 GLU A 151
GLY A 149
SER A 118
THR A 119
 None
None
None
UD1  A 400 (-3.0A)
 1.16A 1kqbA-3vpsA:
undetectable
1kqbB-3vpsA:
undetectable		 1kqbA-3vpsA:
22.50
1kqbB-3vpsA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		4 / 6 GLU A 151
GLY A 149
SER A 118
THR A 119
 None
None
None
UD1  A 400 (-3.0A)
 1.15A 1kqbC-3vpsA:
undetectable
1kqbD-3vpsA:
undetectable		 1kqbC-3vpsA:
22.50
1kqbD-3vpsA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		5 / 12 LEU A  62
ALA A  77
LEU A  76
LEU A  37
VAL A  36
 None
NAD  A 401 (-3.6A)
NAD  A 401 (-4.2A)
None
None
 1.11A 2c12C-3vpsA:
undetectable		 2c12C-3vpsA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		3 / 3 PRO A 199
ASN A 191
ARG A 195
 UD1  A 400 (-4.1A)
None
None
 1.09A 2qeuB-3vpsA:
undetectable		 2qeuB-3vpsA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		5 / 12 GLY A 155
ALA A 154
VAL A  96
GLY A 149
ILE A 168
 None
 0.89A 3ekqA-3vpsA:
undetectable		 3ekqA-3vpsA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		5 / 9 LEU A  72
VAL A  34
GLY A  20
ILE A  19
ILE A  10
 None
None
None
NAD  A 401 (-4.1A)
None
 1.05A 3el0B-3vpsA:
undetectable		 3el0B-3vpsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		5 / 12 GLU A 133
GLN A 278
ASN A 233
VAL A 216
LEU A  23
 None
 1.30A 4k39A-3vpsA:
undetectable		 4k39A-3vpsA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		4 / 7 GLU A 179
THR A 298
GLY A 176
VAL A 174
 NAD  A 401 ( 4.3A)
None
None
NAD  A 401 (-3.9A)
 0.92A 4qwpB-3vpsA:
undetectable		 4qwpB-3vpsA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		5 / 12 GLY A  14
GLY A  17
PRO A  44
LEU A  40
LEU A  37
 NAD  A 401 (-3.2A)
NAD  A 401 (-3.3A)
None
None
None
 1.31A 4x61A-3vpsA:
2.7		 4x61A-3vpsA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		5 / 12 ASP A 209
SER A 236
VAL A 245
ILE A 291
GLY A 290
 None
 1.03A 4y8wA-3vpsA:
undetectable		 4y8wA-3vpsA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		5 / 12 ASP A 209
SER A 236
VAL A 245
ILE A 291
GLY A 290
 None
 1.08A 4y8wB-3vpsA:
undetectable		 4y8wB-3vpsA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		5 / 12 VAL A  59
HIS A  75
LEU A  76
ALA A  77
THR A 119
 NAD  A 401 (-4.1A)
None
NAD  A 401 (-4.2A)
NAD  A 401 (-3.6A)
UD1  A 400 (-3.0A)
 1.10A 5nd3B-3vpsA:
6.4		 5nd3B-3vpsA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		5 / 12 PHE A  18
VAL A 115
GLY A  20
VAL A 217
ILE A 213
 None
 1.36A 5tuiB-3vpsA:
3.9		 5tuiB-3vpsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		3 / 3 LEU A  27
VAL A 217
ASP A 218
 None
 0.64A 5x23A-3vpsA:
undetectable		 5x23A-3vpsA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		3 / 3 LYS A 113
LEU A  72
ARG A  71
 None
 0.86A 5yw0A-3vpsA:
undetectable		 5yw0A-3vpsA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		4 / 7 ILE A  19
LEU A  23
ILE A 168
ALA A 224
 NAD  A 401 (-4.1A)
None
None
None
 0.80A 6b5vA-3vpsA:
undetectable
6b5vC-3vpsA:
undetectable		 6b5vA-3vpsA:
14.33
6b5vC-3vpsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		4 / 7 ILE A  19
LEU A  23
ILE A 168
ALA A 224
 NAD  A 401 (-4.1A)
None
None
None
 0.80A 6b5vC-3vpsA:
undetectable
6b5vD-3vpsA:
undetectable		 6b5vC-3vpsA:
14.33
6b5vD-3vpsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Streptomyces
chartreusis) 		4 / 7 ALA A 224
ILE A  19
LEU A  23
ILE A 168
 None
NAD  A 401 (-4.1A)
None
None
 0.80A 6b5vB-3vpsA:
undetectable
6b5vD-3vpsA:
undetectable		 6b5vB-3vpsA:
14.33
6b5vD-3vpsA:
14.33