SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vpx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		4 / 8 GLY A  78
ASN A  69
GLY A  77
VAL A 294
 None
 0.90A 1dbbH-3vpxA:
undetectable
1dbbL-3vpxA:
undetectable		 1dbbH-3vpxA:
20.97
1dbbL-3vpxA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		4 / 6 LEU A  74
VAL A 291
VAL A 285
SER A 288
 None
 0.93A 1e7aB-3vpxA:
undetectable		 1e7aB-3vpxA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		5 / 10 ALA A 231
SER A 170
LEU A 192
ALA A 197
PHE A 234
 None
 1.19A 1g5yC-3vpxA:
undetectable		 1g5yC-3vpxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		5 / 9 ALA A 160
VAL A 316
GLY A 153
ILE A 154
ILE A 317
 None
 1.04A 1hpvB-3vpxA:
undetectable		 1hpvB-3vpxA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		5 / 9 ASP A 315
VAL A 316
GLY A 153
ILE A 154
ILE A 317
 None
 1.08A 1hpvB-3vpxA:
undetectable		 1hpvB-3vpxA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		5 / 12 TYR A 280
ILE A 243
ILE A 248
ILE A 200
ALA A 231
 None
 1.24A 1jtxA-3vpxA:
undetectable		 1jtxA-3vpxA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		5 / 12 LEU A 106
GLY A  77
GLY A  37
ILE A  31
THR A  43
 None
 0.96A 1p91B-3vpxA:
4.9		 1p91B-3vpxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		5 / 12 VAL A 176
ILE A 286
VAL A 279
ALA A 235
LEU A 192
 None
 0.96A 1r9oA-3vpxA:
undetectable		 1r9oA-3vpxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		5 / 12 TYR A 280
ALA A  72
ASN A 287
SER A 288
ILE A 242
 None
 1.39A 1xvaB-3vpxA:
4.8		 1xvaB-3vpxA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		4 / 5 LEU A  40
ASN A  69
VAL A 360
ALA A 295
 None
 0.90A 2cizA-3vpxA:
undetectable		 2cizA-3vpxA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		5 / 11 ILE A 111
GLY A 135
THR A 136
THR A 112
GLU A 297
 None
 1.06A 2fn1B-3vpxA:
undetectable		 2fn1B-3vpxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		5 / 10 ILE A 126
ALA A 113
ILE A 103
PHE A  99
THR A 134
 None
 1.15A 2w9sC-3vpxA:
undetectable		 2w9sC-3vpxA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		5 / 10 ILE A 126
ALA A 113
ILE A 103
PHE A  99
THR A 134
 None
 1.04A 2w9sD-3vpxA:
undetectable		 2w9sD-3vpxA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		5 / 10 ILE A 126
ALA A 113
ILE A 103
PHE A  99
THR A 134
 None
 1.04A 2w9sF-3vpxA:
undetectable		 2w9sF-3vpxA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		5 / 12 GLY A  41
GLY A  78
ILE A 111
ALA A 113
LEU A  61
 None
 1.19A 3ckkA-3vpxA:
3.8		 3ckkA-3vpxA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		4 / 7 VAL A 133
THR A 112
ILE A 103
THR A  43
 None
 0.84A 3deuA-3vpxA:
undetectable		 3deuA-3vpxA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		5 / 12 PHE A  99
GLY A 100
ILE A 126
ALA A  39
LEU A 106
 None
 1.03A 3hs6B-3vpxA:
undetectable		 3hs6B-3vpxA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA315_0
(UNCHARACTERIZED
PROTEIN)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		5 / 11 THR A  43
THR A 118
PHE A  99
VAL A 133
ILE A 111
 None
 1.36A 3ijdA-3vpxA:
undetectable		 3ijdA-3vpxA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		5 / 12 TYR A 132
GLY A 100
ILE A  29
LEU A 128
ASN A 127
 None
 1.13A 3q87B-3vpxA:
7.1		 3q87B-3vpxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		4 / 7 ASP A 122
GLY A 135
THR A 134
PHE A  99
 None
 1.06A 4ac9C-3vpxA:
undetectable		 4ac9C-3vpxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		4 / 6 THR A 150
GLY A 153
ILE A 286
LEU A 188
 None
 1.07A 4acaC-3vpxA:
undetectable		 4acaC-3vpxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		4 / 6 THR A 150
GLY A 153
ILE A 286
LEU A 188
 None
 1.07A 4acbC-3vpxA:
undetectable		 4acbC-3vpxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		4 / 8 LEU A 251
SER A 228
THR A 175
ASP A 232
 None
 1.03A 4drjB-3vpxA:
undetectable		 4drjB-3vpxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		4 / 6 TYR A 156
LYS A 159
LEU A 192
GLU A 195
 None
 1.20A 4f3tA-3vpxA:
3.5		 4f3tA-3vpxA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		4 / 5 GLY A  41
MET A  65
ASN A  69
GLU A 114
 None
 1.19A 4fglC-3vpxA:
4.2		 4fglC-3vpxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		3 / 3 LYS A  68
ARG A 309
VAL A 310
 None
 0.73A 4x3uA-3vpxA:
undetectable
4x3uB-3vpxA:
undetectable		 4x3uA-3vpxA:
10.84
4x3uB-3vpxA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		5 / 12 GLY A  78
ILE A  28
THR A  43
GLY A  42
GLY A  41
 None
 0.95A 5koxA-3vpxA:
undetectable		 5koxA-3vpxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		4 / 8 GLU A 357
GLY A  37
LEU A  36
THR A  34
 None
 1.08A 5syjA-3vpxA:
undetectable		 5syjA-3vpxA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3vpx LEUCINE
DEHYDROGENASE
(Sporosarcina
psychrophila) 		4 / 7 VAL A 310
VAL A 316
GLY A 157
TYR A 156
 None
 0.95A 5x80C-3vpxA:
undetectable
5x80D-3vpxA:
undetectable		 5x80C-3vpxA:
17.96
5x80D-3vpxA:
17.96