SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vpz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		5 / 12 LEU A 107
ALA A  71
LEU A  12
ILE A 316
ILE A 110
 None
 1.05A 1crbA-3vpzA:
undetectable		 1crbA-3vpzA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		5 / 12 GLY A 170
ALA A 256
GLY A 146
ALA A 257
ILE A 272
 None
 0.99A 1gtnL-3vpzA:
undetectable
1gtnV-3vpzA:
undetectable		 1gtnL-3vpzA:
12.77
1gtnV-3vpzA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		5 / 12 PHE A 202
LEU A 260
MET A 145
ILE A 272
LEU A 270
 None
 1.21A 1lhuA-3vpzA:
undetectable		 1lhuA-3vpzA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		5 / 12 GLY A 146
ALA A 257
ILE A 272
GLY A 170
ALA A 256
 None
 0.96A 1utdL-3vpzA:
undetectable
1utdM-3vpzA:
undetectable		 1utdL-3vpzA:
12.77
1utdM-3vpzA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		5 / 12 GLY A 146
ALA A 257
ILE A 272
GLY A 170
ALA A 256
 None
 0.96A 1utdO-3vpzA:
undetectable
1utdP-3vpzA:
undetectable		 1utdO-3vpzA:
12.77
1utdP-3vpzA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		5 / 11 GLY A 146
ALA A 257
ILE A 272
GLY A 170
ALA A 256
 None
 0.95A 1utdP-3vpzA:
undetectable
1utdQ-3vpzA:
undetectable		 1utdP-3vpzA:
12.77
1utdQ-3vpzA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		4 / 5 GLY A  17
GLY A  18
PHE A  23
PHE A  44
 None
 1.03A 2qr2A-3vpzA:
undetectable
2qr2B-3vpzA:
undetectable		 2qr2A-3vpzA:
22.83
2qr2B-3vpzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		5 / 12 VAL A  63
PHE A 102
PHE A  98
LEU A 107
ALA A  14
 None
 1.33A 3apxA-3vpzA:
undetectable		 3apxA-3vpzA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		5 / 12 GLY A 274
GLY A 275
ILE A 131
ASN A 128
VAL A 311
 None
 0.98A 3nk7A-3vpzA:
undetectable		 3nk7A-3vpzA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		5 / 12 GLU A 291
PHE A 293
SER A 294
ALA A 256
ASP A 251
 None
 1.36A 3nmuA-3vpzA:
3.2
3nmuF-3vpzA:
undetectable		 3nmuA-3vpzA:
22.22
3nmuF-3vpzA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		5 / 11 VAL A 109
PHE A  23
PHE A  44
GLY A  17
GLY A  18
 None
 1.41A 3owxA-3vpzA:
undetectable
3owxB-3vpzA:
undetectable		 3owxA-3vpzA:
20.82
3owxB-3vpzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		5 / 10 ALA A 120
ILE A 316
GLY A 320
ALA A 154
VAL A 144
 None
 1.04A 3t3cB-3vpzA:
undetectable		 3t3cB-3vpzA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		4 / 7 PHE A 113
ASP A 112
PHE A 116
GLY A 274
 None
 1.15A 3vnsA-3vpzA:
undetectable		 3vnsA-3vpzA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		4 / 6 GLY A 320
ALA A 115
TYR A 118
GLU A 108
 None
 0.82A 4ae1A-3vpzA:
undetectable		 4ae1A-3vpzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		5 / 7 GLY A  17
ALA A  14
CYH A  72
ASN A 111
ASP A 112
 None
 1.35A 4ogrE-3vpzA:
undetectable		 4ogrE-3vpzA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		5 / 12 GLY A 268
GLY A 269
GLY A 265
ALA A 261
GLN A 161
 None
 0.93A 4rtmA-3vpzA:
undetectable		 4rtmA-3vpzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		5 / 9 THR A 245
ILE A 230
GLY A 206
THR A 200
LEU A 189
 None
 1.34A 4ze0A-3vpzA:
undetectable		 4ze0A-3vpzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		5 / 11 VAL A 109
PHE A  23
PHE A  44
GLY A  17
GLY A  18
 None
 1.45A 4zvmA-3vpzA:
undetectable
4zvmB-3vpzA:
undetectable		 4zvmA-3vpzA:
22.83
4zvmB-3vpzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		4 / 6 SER A 203
GLY A 258
ASP A 259
GLY A 254
 None
 0.93A 5cdnC-3vpzA:
undetectable
5cdnD-3vpzA:
undetectable		 5cdnC-3vpzA:
21.53
5cdnD-3vpzA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		4 / 6 SER A 203
GLY A 258
ASP A 259
GLY A 254
 None
 0.95A 5cdnT-3vpzA:
undetectable
5cdnU-3vpzA:
undetectable		 5cdnT-3vpzA:
21.53
5cdnU-3vpzA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		4 / 7 GLY A 171
PHE A 289
CYH A 155
PHE A 293
 None
 1.13A 5hieA-3vpzA:
undetectable		 5hieA-3vpzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		4 / 7 ILE A  16
GLY A  17
CYH A  72
ASP A 112
 None
 0.73A 5hieB-3vpzA:
undetectable		 5hieB-3vpzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		4 / 7 ILE A  11
VAL A  84
ILE A  16
CYH A 324
 None
 0.96A 5hieC-3vpzA:
undetectable		 5hieC-3vpzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		4 / 8 ILE A  16
GLY A  17
CYH A  72
ASP A 112
 None
 0.74A 5hieD-3vpzA:
undetectable		 5hieD-3vpzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		5 / 12 SER A 294
ALA A 261
PHE A 289
GLN A 281
LEU A 284
 None
 0.97A 5tudD-3vpzA:
undetectable		 5tudD-3vpzA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		5 / 12 PHE A 293
ILE A 316
ALA A 119
ILE A 142
ALA A 143
 None
 1.21A 5vc0A-3vpzA:
undetectable		 5vc0A-3vpzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vpz GLUCOKINASE
(Pseudoalteromona
s
sp.
AS-131) 		3 / 3 MET A 214
ASP A 182
ARG A 288
 None
 1.18A 5z6jA-3vpzA:
undetectable		 5z6jA-3vpzA:
20.76