SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vqr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		3 / 3 ALA A 374
VAL A 232
TRP A 233
 EDO  A1003 ( 4.0A)
ACT  A1002 ( 3.3A)
FAD  A1001 (-4.7A)
 0.86A 1kqeA-3vqrA:
undetectable
1kqeE-3vqrA:
undetectable		 1kqeA-3vqrA:
2.65
1kqeE-3vqrA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		3 / 3 ALA A 374
VAL A 232
TRP A 233
 EDO  A1003 ( 4.0A)
ACT  A1002 ( 3.3A)
FAD  A1001 (-4.7A)
 0.87A 1kqeB-3vqrA:
undetectable
1kqeD-3vqrA:
undetectable		 1kqeB-3vqrA:
2.65
1kqeD-3vqrA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		3 / 3 TRP A 233
ALA A 374
VAL A 232
 FAD  A1001 (-4.7A)
EDO  A1003 ( 4.0A)
ACT  A1002 ( 3.3A)
 0.87A 1kqeB-3vqrA:
undetectable
1kqeD-3vqrA:
undetectable		 1kqeB-3vqrA:
2.65
1kqeD-3vqrA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		3 / 3 ALA A 374
VAL A 232
TRP A 233
 EDO  A1003 ( 4.0A)
ACT  A1002 ( 3.3A)
FAD  A1001 (-4.7A)
 0.84A 1micA-3vqrA:
undetectable
1micB-3vqrA:
undetectable		 1micA-3vqrA:
3.81
1micB-3vqrA:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 5 ILE A 117
ARG A 125
LEU A  89
PRO A 280
 None
 1.17A 1s8fA-3vqrA:
undetectable
1s8fB-3vqrA:
1.8		 1s8fA-3vqrA:
18.83
1s8fB-3vqrA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		5 / 12 ALA A 138
GLY A 142
LEU A 141
VAL A  91
PRO A 285
 None
 1.20A 1vpoH-3vqrA:
undetectable
1vpoL-3vqrA:
undetectable		 1vpoH-3vqrA:
18.54
1vpoL-3vqrA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		5 / 12 ILE A 267
ARG A 266
LEU A 126
LEU A 151
ILE A 117
 None
 1.26A 1xzxX-3vqrA:
undetectable		 1xzxX-3vqrA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		5 / 12 GLY A 388
TYR A 404
VAL A 362
ALA A 229
ALA A  18
 None
 1.18A 2avdA-3vqrA:
2.9		 2avdA-3vqrA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		5 / 12 GLY A 388
TYR A 404
VAL A 362
ALA A 229
ALA A  18
 None
 1.13A 2avdB-3vqrA:
2.9		 2avdB-3vqrA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 8 TYR A 167
ASP A 385
TYR A 166
TYR A  21
 None
 1.38A 2ha2A-3vqrA:
undetectable		 2ha2A-3vqrA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 8 TYR A 167
ASP A 385
TYR A 166
TYR A  21
 None
 1.37A 2ha2B-3vqrA:
undetectable		 2ha2B-3vqrA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 6 SER A  56
ARG A  52
PHE A  54
ILE A 152
 None
 1.14A 2qeiA-3vqrA:
undetectable		 2qeiA-3vqrA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		3 / 3 ARG A  46
GLN A 318
PRO A 317
 None
 0.87A 2qhfA-3vqrA:
undetectable		 2qhfA-3vqrA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		5 / 11 LEU A 226
VAL A 222
GLY A 223
ILE A 370
ALA A 209
 None
 1.13A 2yy8A-3vqrA:
undetectable
2yy8B-3vqrA:
undetectable		 2yy8A-3vqrA:
17.11
2yy8B-3vqrA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		3 / 3 SER A 234
GLY A 231
SER A 247
 EDO  A1003 ( 4.4A)
ACT  A1002 (-3.3A)
EDO  A1003 (-4.4A)
 0.67A 3loqA-3vqrA:
2.2		 3loqA-3vqrA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 7 ILE A 116
LEU A  89
THR A 130
ARG A 124
 None
 1.12A 3nxuA-3vqrA:
undetectable		 3nxuA-3vqrA:
21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		6 / 6 ASP A  43
GLY A 231
VAL A 232
TRP A 233
ASP A 353
THR A 376
 ACT  A1002 ( 3.1A)
ACT  A1002 (-3.3A)
ACT  A1002 ( 3.3A)
FAD  A1001 (-4.7A)
EDO  A1003 ( 2.9A)
FAD  A1001 ( 3.2A)
 0.00A 3vqrA-3vqrA:
70.6		 3vqrA-3vqrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		5 / 5 ASP A  43
GLY A 231
VAL A 232
ASP A 353
THR A 376
 ACT  A1002 ( 3.1A)
ACT  A1002 (-3.3A)
ACT  A1002 ( 3.3A)
EDO  A1003 ( 2.9A)
FAD  A1001 ( 3.2A)
 0.08A 3vqrB-3vqrA:
68.7		 3vqrB-3vqrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 8 GLU A 109
GLU A 110
ARG A 153
ARG A 112
 None
 1.03A 4fgzA-3vqrA:
undetectable
4fgzB-3vqrA:
undetectable		 4fgzA-3vqrA:
18.98
4fgzB-3vqrA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 8 VAL A  14
VAL A  32
ASP A  34
VAL A   8
 FAD  A1001 (-3.9A)
None
FAD  A1001 (-2.6A)
None
 1.04A 4l4bA-3vqrA:
undetectable		 4l4bA-3vqrA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		5 / 10 ASP A  34
VAL A  13
GLY A 231
SER A  41
GLY A  45
 FAD  A1001 (-2.6A)
FAD  A1001 (-4.6A)
ACT  A1002 (-3.3A)
FAD  A1001 ( 3.8A)
None
 1.45A 4mmcA-3vqrA:
undetectable		 4mmcA-3vqrA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		5 / 12 GLY A  45
GLY A  40
LEU A  16
ALA A 160
ARG A 256
 None
 1.06A 4qtuB-3vqrA:
3.0		 4qtuB-3vqrA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		5 / 12 GLY A  15
ALA A 229
SER A 172
ASP A  34
PRO A  39
 None
None
None
FAD  A1001 (-2.6A)
None
 1.18A 4rtpA-3vqrA:
2.2		 4rtpA-3vqrA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 6 LEU A 141
SER A 333
PRO A 337
PHE A 339
 None
 1.16A 5b8iA-3vqrA:
undetectable		 5b8iA-3vqrA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 6 TYR A 167
ASP A 385
TYR A 166
TYR A  21
 None
 1.40A 5e2iA-3vqrA:
undetectable		 5e2iA-3vqrA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 5 SER A  86
VAL A  84
GLY A 277
ALA A 278
 None
 1.02A 5k50A-3vqrA:
3.9		 5k50A-3vqrA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 8 SER A 379
TYR A  88
SER A  57
ASN A  60
 None
 1.07A 5l1fA-3vqrA:
undetectable
5l1fB-3vqrA:
undetectable		 5l1fA-3vqrA:
21.23
5l1fB-3vqrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 7 TYR A  21
THR A  67
VAL A 163
TYR A 167
 None
 1.12A 5ov9A-3vqrA:
undetectable		 5ov9A-3vqrA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 8 TYR A  21
THR A  67
VAL A 163
TYR A 167
 None
 1.12A 5ov9B-3vqrA:
undetectable		 5ov9B-3vqrA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 7 ILE A 116
LEU A  89
THR A 130
ARG A 124
 None
 1.01A 5vc0A-3vqrA:
undetectable		 5vc0A-3vqrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		5 / 12 ALA A  35
GLY A  12
GLY A  10
SER A 384
ASP A  43
 FAD  A1001 (-3.7A)
FAD  A1001 (-3.4A)
FAD  A1001 (-3.4A)
None
ACT  A1002 ( 3.1A)
 1.20A 6clxA-3vqrA:
undetectable		 6clxA-3vqrA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 8 VAL A  14
VAL A  32
ASP A  34
VAL A   8
 FAD  A1001 (-3.9A)
None
FAD  A1001 (-2.6A)
None
 1.06A 6cp4A-3vqrA:
undetectable		 6cp4A-3vqrA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		3 / 3 TYR A 167
ALA A  74
LEU A  70
 None
 0.64A 6d9kF-3vqrA:
undetectable		 6d9kF-3vqrA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 3vqr PUTATIVE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 7 ILE A 243
LEU A 241
VAL A 184
LEU A 237
 EDO  A1004 (-4.4A)
None
FAD  A1001 (-3.9A)
FAD  A1001 ( 4.3A)
 0.71A 6g9bA-3vqrA:
undetectable
6g9bB-3vqrA:
undetectable		 6g9bA-3vqrA:
11.87
6g9bB-3vqrA:
10.00