SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vr0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		3 / 3 GLN A 107
HIS A 116
PRO A 110
 AU  A 303 (-4.4A)
AU  A 303 (-3.5A)
None
 0.98A 1d8cA-3vr0A:
undetectable		 1d8cA-3vr0A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 LEU A 194
GLU A 134
THR A 132
VAL A 127
 None
 0.96A 1sn5C-3vr0A:
undetectable		 1sn5C-3vr0A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 153
GLY A 139
TYR A 141
ALA A 190
ALA A 189
 None
AU  A 304 ( 3.7A)
None
None
AU  A 303 (-4.1A)
 1.14A 2bm9D-3vr0A:
undetectable		 2bm9D-3vr0A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 153
GLY A 139
TYR A 141
ALA A 190
ALA A 189
 None
AU  A 304 ( 3.7A)
None
None
AU  A 303 (-4.1A)
 1.27A 2br4B-3vr0A:
undetectable		 2br4B-3vr0A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 232
VAL A 224
LEU A 225
ILE A 101
ALA A  56
 None
 0.99A 2gj5A-3vr0A:
undetectable		 2gj5A-3vr0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 VAL A 216
GLY A  40
LYS A 219
ARG A 244
 None
 0.75A 3bjwC-3vr0A:
undetectable		 3bjwC-3vr0A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 VAL A 216
GLY A  40
LYS A 219
ARG A 244
 None
 0.68A 3bjwA-3vr0A:
undetectable		 3bjwA-3vr0A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 124
LEU A  62
GLY A 191
ALA A 189
LEU A  36
 None
None
None
AU  A 303 (-4.1A)
None
 1.02A 3n8xB-3vr0A:
undetectable		 3n8xB-3vr0A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A  62
LEU A  36
GLY A 121
ALA A 120
LEU A 193
 None
 1.06A 3nt1A-3vr0A:
undetectable		 3nt1A-3vr0A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A  62
LEU A  36
GLY A 121
ALA A 120
LEU A 193
 None
 1.09A 3nt1B-3vr0A:
undetectable		 3nt1B-3vr0A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A  36
GLY A 121
LEU A 124
PHE A 117
PHE A  32
 None
 1.17A 3tbgC-3vr0A:
undetectable		 3tbgC-3vr0A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 PHE A  32
GLY A 121
ILE A  19
PHE A  86
 None
 0.84A 4ejjD-3vr0A:
undetectable		 4ejjD-3vr0A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_A_VK3A202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 5 ARG A  97
TYR A 165
TYR A 164
LEU A 161
 None
 1.09A 4f8yA-3vr0A:
2.1
4f8yB-3vr0A:
2.1		 4f8yA-3vr0A:
22.85
4f8yB-3vr0A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 ARG A  97
TYR A 165
TYR A 164
LEU A 161
 None
 1.11A 4f8yA-3vr0A:
2.2
4f8yB-3vr0A:
2.1		 4f8yA-3vr0A:
22.85
4f8yB-3vr0A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 ARG A  97
TYR A 165
TYR A 164
LEU A 161
 None
 1.18A 4f8yC-3vr0A:
2.1
4f8yD-3vr0A:
1.9		 4f8yC-3vr0A:
22.85
4f8yD-3vr0A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 GLY A  43
GLY A 139
GLY A 209
LEU A  36
ALA A  47
 None
AU  A 304 ( 3.7A)
None
None
None
 0.95A 4uciA-3vr0A:
undetectable		 4uciA-3vr0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 GLY A  43
GLY A 139
GLY A 209
LEU A  36
ALA A  47
 None
AU  A 304 ( 3.7A)
None
None
None
 0.96A 4uciB-3vr0A:
undetectable		 4uciB-3vr0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 LEU A 124
ALA A 120
LEU A 192
LEU A 194
LEU A  36
 None
 1.37A 5hyrB-3vr0A:
undetectable		 5hyrB-3vr0A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A 124
LEU A  62
GLY A 191
ALA A 189
LEU A  36
 None
None
None
AU  A 303 (-4.1A)
None
 1.04A 5ikrB-3vr0A:
undetectable		 5ikrB-3vr0A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 LEU A  62
LEU A  36
GLY A 121
ALA A 120
LEU A 193
 None
 1.13A 5jvzB-3vr0A:
undetectable		 5jvzB-3vr0A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ILE A 101
ILE A 236
LEU A  99
THR A 229
LEU A 232
 None
 0.85A 5tiwA-3vr0A:
1.7		 5tiwA-3vr0A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 PHE A 126
ALA A  60
THR A 103
LEU A  36
ALA A  47
 None
 1.48A 6efnA-3vr0A:
undetectable		 6efnA-3vr0A:
20.34