SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vr5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		4 / 7 HIS D 242
GLY D 296
LEU D 235
ALA D 236
 None
 0.85A 1dmaA-3vr5D:
undetectable		 1dmaA-3vr5D:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		4 / 8 VAL A 269
ASP A 329
HIS A 243
LEU A 276
 None
 1.08A 1pk2A-3vr5A:
undetectable		 1pk2A-3vr5A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		5 / 12 ILE A 577
ILE A 581
ILE A 545
VAL A 492
LEU A 488
 None
 0.91A 1qhyA-3vr5A:
2.4		 1qhyA-3vr5A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		4 / 6 GLU A 399
ARG A 339
ARG D 270
TYR A 354
 None
 1.48A 1tufA-3vr5A:
undetectable
1tufB-3vr5A:
undetectable		 1tufA-3vr5A:
21.38
1tufB-3vr5A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae;
Enterococcus
hirae) 		4 / 5 LEU A  91
ASN D 117
VAL A 270
ALA A 293
 None
 1.01A 2cizA-3vr5A:
undetectable		 2cizA-3vr5A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		3 / 3 SER A 249
THR A 218
GLN A 518
 None
 0.70A 2fk8A-3vr5A:
3.3		 2fk8A-3vr5A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		5 / 11 TYR A 366
LEU A 362
LEU A 358
ILE A 307
LEU A 406
 None
 1.32A 2ft9A-3vr5A:
undetectable		 2ft9A-3vr5A:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		4 / 6 PRO A 355
LEU A 345
ARG A 339
GLY D 269
 None
 1.08A 2hs2B-3vr5A:
undetectable		 2hs2B-3vr5A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		4 / 6 PRO A 355
LEU A 345
ARG A 339
GLY D 275
 None
 1.02A 2hs2B-3vr5A:
undetectable		 2hs2B-3vr5A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae;
Enterococcus
hirae) 		4 / 6 LEU A  91
ASN D 117
VAL A 270
ALA A 293
 None
 1.07A 2j5mA-3vr5A:
undetectable		 2j5mA-3vr5A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		5 / 11 ALA A 314
VAL A 290
ILE A  79
VAL A 257
VAL A 255
 None
 1.08A 2nnpB-3vr5A:
undetectable		 2nnpB-3vr5A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		4 / 5 ILE D 111
LEU D  79
ASP D  91
ALA D 223
 None
 0.87A 2opxA-3vr5D:
undetectable		 2opxA-3vr5D:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		4 / 7 ILE D 103
LEU D 235
LEU D  79
GLY D  80
 None
 0.93A 2qqcD-3vr5D:
undetectable
2qqcE-3vr5D:
undetectable		 2qqcD-3vr5D:
13.25
2qqcE-3vr5D:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		4 / 8 ILE D 103
LEU D 235
LEU D  79
GLY D  80
 None
 0.91A 2qqcH-3vr5D:
undetectable
2qqcK-3vr5D:
undetectable		 2qqcH-3vr5D:
13.25
2qqcK-3vr5D:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT D
V-TYPE SODIUM ATPASE
SUBUNIT G
(Enterococcus
hirae) 		4 / 8 ILE H  74
GLY H  46
MET G 105
ILE H   5
 None
 0.95A 2qwxA-3vr5H:
undetectable
2qwxB-3vr5H:
undetectable		 2qwxA-3vr5H:
19.91
2qwxB-3vr5H:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		6 / 9 ARG A 197
LEU A  75
ILE A 173
GLY A 137
ILE A 135
PRO A 152
 None
 1.28A 2r5qA-3vr5A:
undetectable		 2r5qA-3vr5A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		6 / 9 ARG A 197
LEU A  75
ILE A 173
GLY A 137
ILE A 135
PRO A 152
 None
 1.28A 2r5qC-3vr5A:
undetectable		 2r5qC-3vr5A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		4 / 8 PRO D 316
GLU D 255
ALA D 254
PRO D 307
 None
 1.16A 2v41G-3vr5D:
undetectable
2v41H-3vr5D:
undetectable		 2v41G-3vr5D:
18.68
2v41H-3vr5D:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		3 / 3 LEU D  15
MET D  53
MET D  34
 None
 0.87A 2vavF-3vr5D:
undetectable		 2vavF-3vr5D:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		3 / 3 PRO A 205
GLY A 226
TYR A 437
 None
 0.71A 2vouA-3vr5A:
undetectable		 2vouA-3vr5A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		3 / 3 PRO A 205
GLY A 226
TYR A 437
 None
 0.68A 2vouB-3vr5A:
undetectable		 2vouB-3vr5A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		3 / 3 PRO A 205
GLY A 226
TYR A 437
 None
 0.69A 2vouC-3vr5A:
undetectable		 2vouC-3vr5A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		3 / 3 ARG A 339
GLU A 336
SER D 261
 None
 0.91A 2xctD-3vr5A:
3.2		 2xctD-3vr5A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		5 / 9 THR A 142
SER A 164
ILE A 135
ILE A  80
GLY A  78
 None
 0.94A 3cv9A-3vr5A:
undetectable		 3cv9A-3vr5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		5 / 12 LEU D  79
GLY D  92
GLY D  94
ALA D 223
THR D 224
 None
 0.82A 3dh0B-3vr5D:
2.9		 3dh0B-3vr5D:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		4 / 8 HIS A 424
ILE A 428
ASN A 429
PRO A 426
 None
 1.01A 3fxrA-3vr5A:
undetectable		 3fxrA-3vr5A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		3 / 3 GLU A 381
ASP A 323
ASP A 206
 None
 0.78A 3jb2A-3vr5A:
undetectable		 3jb2A-3vr5A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		5 / 12 ILE D 132
ASP D 136
THR D 130
ILE D 327
PRO D 340
 None
 1.17A 3kpbA-3vr5D:
undetectable		 3kpbA-3vr5D:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		5 / 12 ILE D 132
ASP D 136
THR D 130
ILE D 327
PRO D 340
 None
 1.19A 3kpbC-3vr5D:
undetectable		 3kpbC-3vr5D:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		3 / 3 VAL D  11
VAL D  32
SER D  68
 None
 0.67A 3n8xB-3vr5D:
undetectable		 3n8xB-3vr5D:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT D
V-TYPE SODIUM ATPASE
SUBUNIT G
(Enterococcus
hirae) 		4 / 7 ILE G  54
LEU G  50
TYR H  49
ILE H  74
 None
 0.85A 3p50C-3vr5G:
2.6		 3p50C-3vr5G:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT D
V-TYPE SODIUM ATPASE
SUBUNIT G
(Enterococcus
hirae) 		4 / 7 ILE G  54
LEU G  50
TYR H  49
ILE H  74
 None
 0.86A 3p50D-3vr5G:
2.7		 3p50D-3vr5G:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT D
V-TYPE SODIUM ATPASE
SUBUNIT G
(Enterococcus
hirae) 		4 / 7 ILE G  54
LEU G  50
TYR H  49
ILE H  74
 None
 0.86A 3p50E-3vr5G:
2.6		 3p50E-3vr5G:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		4 / 6 ILE A 311
TYR A 365
ASP A 329
THR A 402
 None
 0.95A 3q70A-3vr5A:
undetectable		 3q70A-3vr5A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		4 / 6 THR A 402
SER A 433
ILE A 428
THR A 405
 None
 1.11A 3q70A-3vr5A:
undetectable		 3q70A-3vr5A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		5 / 11 ARG A 555
SER A 557
ILE A 556
VAL A 524
ILE A 562
 None
 1.23A 3rf4A-3vr5A:
undetectable
3rf4C-3vr5A:
undetectable		 3rf4A-3vr5A:
11.13
3rf4C-3vr5A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		5 / 11 ILE A 562
ARG A 555
SER A 557
ILE A 556
VAL A 524
 None
 1.22A 3rf4A-3vr5A:
undetectable
3rf4B-3vr5A:
undetectable		 3rf4A-3vr5A:
11.13
3rf4B-3vr5A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		5 / 11 ILE A 562
ARG A 555
SER A 557
ILE A 556
VAL A 524
 None
 1.18A 3rf4B-3vr5A:
undetectable
3rf4C-3vr5A:
undetectable		 3rf4B-3vr5A:
11.13
3rf4C-3vr5A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		5 / 9 PHE A  84
VAL A  73
PHE A 317
ILE A  79
GLY A  76
 None
 1.37A 3t3rB-3vr5A:
undetectable		 3t3rB-3vr5A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		5 / 9 PHE A  84
VAL A  73
PHE A 317
ILE A  79
GLY A  76
 None
 1.42A 3t3rC-3vr5A:
undetectable		 3t3rC-3vr5A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		5 / 12 LEU D 141
LEU D 304
ILE D 301
GLN D 300
ALA D 288
 None
 1.09A 4ltwA-3vr5D:
undetectable		 4ltwA-3vr5D:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		5 / 12 ILE D 246
ILE D 135
GLN D 163
LEU D 329
ILE D 303
 None
 0.92A 4m2xC-3vr5D:
undetectable		 4m2xC-3vr5D:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		5 / 12 CYH A  28
ASN A  18
ALA A  16
ILE A  49
ILE A   6
 None
 1.27A 5eypB-3vr5A:
2.3		 5eypB-3vr5A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		4 / 6 PHE A 528
ARG A 553
GLU A 491
PHE A 542
 None
 1.10A 5h4dA-3vr5A:
undetectable		 5h4dA-3vr5A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		6 / 12 TYR D  26
ILE D 222
ALA D 223
TYR D 253
GLY A  11
LEU D  77
 None
 1.33A 5i73A-3vr5D:
undetectable		 5i73A-3vr5D:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		5 / 9 LEU A 103
GLY A  86
ALA A 302
GLY A 260
VAL D 115
 None
 1.05A 5kr0B-3vr5A:
undetectable		 5kr0B-3vr5A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		4 / 7 PRO D 225
TYR D 253
SER A  56
ASN D 112
 None
 1.17A 5l1fC-3vr5D:
undetectable		 5l1fC-3vr5D:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		5 / 12 ILE A  39
SER A  23
ALA A  22
ALA A  47
VAL A  64
 None
 1.01A 5n0oB-3vr5A:
1.8		 5n0oB-3vr5A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		4 / 5 TYR A 434
ALA A 229
GLN A 403
THR A 405
 None
 0.89A 5n0wB-3vr5A:
3.1		 5n0wB-3vr5A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		4 / 5 TYR A 434
ALA A 229
GLN A 403
THR A 405
 None
 0.93A 5n4iA-3vr5A:
1.6		 5n4iA-3vr5A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae) 		5 / 12 PHE D 193
GLY D 416
LEU D 160
HIS D 157
PHE D 194
 None
 1.18A 5v5zA-3vr5D:
undetectable		 5v5zA-3vr5D:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		5 / 12 CYH A  28
ASN A  18
ALA A  16
ILE A  49
ILE A   6
 None
 1.32A 5xiwD-3vr5A:
2.3		 5xiwD-3vr5A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
V-TYPE SODIUM ATPASE
SUBUNIT B
(Enterococcus
hirae;
Enterococcus
hirae) 		3 / 3 VAL A   9
TYR D  26
GLU A  62
 None
 0.91A 5zmqD-3vr5A:
undetectable
5zmqE-3vr5A:
undetectable		 5zmqD-3vr5A:
15.51
5zmqE-3vr5A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		5 / 12 ILE A 311
GLY A 310
ILE A 313
VAL A 251
ILE A 384
 None
 0.97A 6emuB-3vr5A:
undetectable		 6emuB-3vr5A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
(Enterococcus
hirae) 		5 / 12 ILE A 311
GLY A 310
ILE A 313
VAL A 251
ILE A 384
 None
 1.07A 6emuC-3vr5A:
undetectable		 6emuC-3vr5A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 3vr5 V-TYPE SODIUM ATPASE
SUBUNIT D
V-TYPE SODIUM ATPASE
SUBUNIT G
(Enterococcus
hirae) 		4 / 5 ILE G  54
GLN G  59
THR G  58
LEU H  87
 None
 1.00A 6f3mD-3vr5G:
undetectable		 6f3mD-3vr5G:
19.17