SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vrb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 6 LEU A 554
ILE A 618
ASP A 612
PRO A 613
 None
 1.16A 1ditH-3vrbA:
undetectable
1ditP-3vrbA:
undetectable		 1ditH-3vrbA:
17.01
1ditP-3vrbA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 12 ASN A 551
ILE A 273
GLY A 240
THR A 247
TYR A 243
 None
None
None
FAD  A 702 (-4.6A)
None
 1.24A 1g60B-3vrbA:
undetectable		 1g60B-3vrbA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		3 / 3 TRP A 637
VAL A 625
TRP A 112
 None
 1.43A 1gmkC-3vrbA:
undetectable
1gmkD-3vrbA:
undetectable		 1gmkC-3vrbA:
1.89
1gmkD-3vrbA:
1.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 12 ALA A 258
GLY A 238
LEU A 204
ALA A 418
LEU A 259
 None
 1.42A 1jipA-3vrbA:
undetectable		 1jipA-3vrbA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 10 GLY A  86
LEU A 433
GLN A 156
ASN A  88
GLY A  85
 FAD  A 702 (-4.3A)
None
None
None
FAD  A 702 ( 3.3A)
 1.14A 1kvlA-3vrbA:
undetectable		 1kvlA-3vrbA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 8 TYR A 310
ILE A 329
GLU A 330
ARG A 335
 None
 0.72A 1mrjA-3vrbA:
undetectable		 1mrjA-3vrbA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		5 / 7 LEU B 176
GLU B 172
ARG B 213
ASP B 217
GLY A 137
 None
 1.25A 1n13D-3vrbB:
undetectable
1n13E-3vrbB:
undetectable		 1n13D-3vrbB:
15.77
1n13E-3vrbB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		5 / 7 LEU B 176
GLU B 172
ASP B 217
LEU B 153
GLY A 137
 None
 1.47A 1n13D-3vrbB:
undetectable
1n13E-3vrbB:
undetectable		 1n13D-3vrbB:
15.77
1n13E-3vrbB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		4 / 7 VAL A 283
GLY B  92
ILE B  93
THR A 247
 None
FES  B 301 ( 3.8A)
None
FAD  A 702 (-4.6A)
 0.79A 1t7iB-3vrbA:
undetectable		 1t7iB-3vrbA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		4 / 7 VAL A 283
GLY B  92
ILE B  93
THR A 247
 None
FES  B 301 ( 3.8A)
None
FAD  A 702 (-4.6A)
 0.82A 1t7jB-3vrbA:
undetectable		 1t7jB-3vrbA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 12 LEU A 259
PHE A 227
GLY A 213
LEU A 202
ALA A 216
 None
 1.01A 1v2xA-3vrbA:
3.4		 1v2xA-3vrbA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 12 GLY A 470
GLY A 468
ASP A 203
PHE A 227
SER A 473
 None
 0.97A 1wg8A-3vrbA:
3.3		 1wg8A-3vrbA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3vrb IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		5 / 12 PHE B 130
LEU B 141
SER B 148
LEU B 203
VAL B 207
 None
 1.16A 2po7A-3vrbB:
undetectable		 2po7A-3vrbB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		3 / 3 ARG A 566
ASN A 555
THR A 609
 None
 0.67A 2q63A-3vrbA:
undetectable		 2q63A-3vrbA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6U_A_BEZA501_0
(NIKD PROTEIN)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 7 ARG A 570
GLU A 568
PHE A 272
TRP A 603
 None
 1.31A 2q6uA-3vrbA:
13.6		 2q6uA-3vrbA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 12 LEU A 433
ASP A 440
THR A 169
GLY A  86
GLY A  85
 None
None
None
FAD  A 702 (-4.3A)
FAD  A 702 ( 3.3A)
 1.21A 2uvnA-3vrbA:
undetectable		 2uvnA-3vrbA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3vrb IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		4 / 6 LEU B 227
ALA B 211
LEU B 208
ALA B 258
 None
 0.96A 2vcvB-3vrbB:
undetectable		 2vcvB-3vrbB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3vrb IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		4 / 7 LEU B 227
ALA B 211
LEU B 208
ALA B 258
 None
 0.89A 2vcvG-3vrbB:
undetectable		 2vcvG-3vrbB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3vrb IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		4 / 6 LEU B 227
ALA B 211
LEU B 208
ALA B 258
 None
 0.95A 2vcvK-3vrbB:
undetectable		 2vcvK-3vrbB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 8 ARG A 320
HIS A 428
THR A 169
GLN A 156
 FUM  A 701 (-3.2A)
None
None
None
 1.31A 2vxaF-3vrbA:
undetectable
2vxaG-3vrbA:
undetectable
2vxaI-3vrbA:
undetectable		 2vxaF-3vrbA:
9.31
2vxaG-3vrbA:
9.31
2vxaI-3vrbA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 8 HIS A 428
GLN A 274
THR A 169
GLN A 156
 None
 1.48A 2vxaF-3vrbA:
undetectable
2vxaG-3vrbA:
undetectable
2vxaI-3vrbA:
undetectable		 2vxaF-3vrbA:
9.31
2vxaG-3vrbA:
9.31
2vxaI-3vrbA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		5 / 11 GLN A  84
GLU B  91
THR A 366
ARG A 320
GLY A 279
 None
FAD  A 702 ( 4.4A)
None
FUM  A 701 (-3.2A)
None
 1.39A 3abkA-3vrbA:
1.6
3abkB-3vrbA:
undetectable
3abkT-3vrbA:
undetectable		 3abkA-3vrbA:
22.27
3abkB-3vrbA:
15.62
3abkT-3vrbA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		5 / 11 GLN A  84
GLU B  91
THR A 366
ARG A 320
GLY A 279
 None
FAD  A 702 ( 4.4A)
None
FUM  A 701 (-3.2A)
None
 1.44A 3ablA-3vrbA:
1.2
3ablB-3vrbA:
undetectable
3ablT-3vrbA:
undetectable		 3ablA-3vrbA:
22.27
3ablB-3vrbA:
15.62
3ablT-3vrbA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 8 VAL A 165
ASP A 105
LEU A 433
GLY A 154
 None
 0.99A 3af0A-3vrbA:
undetectable		 3af0A-3vrbA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		5 / 11 GLN A  84
GLU B  91
THR A 366
ARG A 320
GLY A 279
 None
FAD  A 702 ( 4.4A)
None
FUM  A 701 (-3.2A)
None
 1.39A 3ag3A-3vrbA:
1.2
3ag3B-3vrbA:
undetectable
3ag3T-3vrbA:
undetectable		 3ag3A-3vrbA:
22.27
3ag3B-3vrbA:
15.62
3ag3T-3vrbA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 11 THR A 106
LEU A 433
ARG A 320
ASN A 431
LEU A 122
 None
None
FUM  A 701 (-3.2A)
None
None
 1.27A 3ndvA-3vrbA:
undetectable
3ndvB-3vrbA:
undetectable		 3ndvA-3vrbA:
22.33
3ndvB-3vrbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 11 LEU A 122
THR A 106
LEU A 433
ARG A 320
ASN A 431
 None
None
None
FUM  A 701 (-3.2A)
None
 1.31A 3ndvA-3vrbA:
undetectable
3ndvB-3vrbA:
undetectable		 3ndvA-3vrbA:
22.33
3ndvB-3vrbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 11 THR A 106
LEU A 433
ARG A 320
ASN A 431
LEU A 122
 None
None
FUM  A 701 (-3.2A)
None
None
 1.28A 3ndvC-3vrbA:
undetectable
3ndvD-3vrbA:
undetectable		 3ndvC-3vrbA:
22.33
3ndvD-3vrbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 11 LEU A 122
THR A 106
LEU A 433
ARG A 320
ASN A 431
 None
None
None
FUM  A 701 (-3.2A)
None
 1.28A 3ndvC-3vrbA:
undetectable
3ndvD-3vrbA:
undetectable		 3ndvC-3vrbA:
22.33
3ndvD-3vrbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 3vrb IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		5 / 12 LEU B 266
TYR B 202
LEU B 208
GLY B 204
SER B 194
 None
None
None
None
F3S  B 303 (-4.4A)
 1.34A 3okxA-3vrbB:
undetectable		 3okxA-3vrbB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3vrb IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		5 / 12 LEU B 266
TYR B 202
LEU B 208
GLY B 204
SER B 194
 None
None
None
None
F3S  B 303 (-4.4A)
 1.34A 3okxB-3vrbB:
undetectable		 3okxB-3vrbB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 11 ARG A 292
LEU A 346
ASP A 374
VAL A 382
ILE A 380
 None
 1.11A 3oxxB-3vrbA:
undetectable		 3oxxB-3vrbA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		3 / 3 HIS A 250
SER A 541
ASN B  77
 None
 0.63A 3s8pB-3vrbA:
undetectable		 3s8pB-3vrbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 12 GLY A  50
GLY A 420
ALA A 441
ARG A  55
ALA A 447
 FAD  A 702 (-3.0A)
FAD  A 702 (-3.6A)
FAD  A 702 ( 4.3A)
None
None
 0.97A 3sugA-3vrbA:
undetectable		 3sugA-3vrbA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 4 ASN A 555
ALA A 258
GLY A 254
THR A 253
 None
 1.39A 4bboC-3vrbA:
undetectable		 4bboC-3vrbA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		3 / 3 HIS A 250
GLU A 545
ASN B  77
 None
 0.93A 4bupB-3vrbA:
undetectable		 4bupB-3vrbA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 7 GLY A  53
GLY A 445
HIS A 425
CYH A 448
 None
 0.89A 4c5nA-3vrbA:
undetectable		 4c5nA-3vrbA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 6 THR A 559
TYR A 243
HIS A 573
TYR A 239
 None
 1.34A 4df2A-3vrbA:
undetectable		 4df2A-3vrbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 11 SER A 291
GLY A 290
ILE A 363
ILE A 280
HIS A 387
 None
None
None
None
FUM  A 701 ( 3.6A)
 1.01A 4dt8A-3vrbA:
undetectable		 4dt8A-3vrbA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		4 / 6 PHE A  74
ASN B 140
ALA B 144
LEU A 189
 None
 0.77A 4ejgD-3vrbA:
undetectable		 4ejgD-3vrbA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 8 ASN A 252
THR A 257
MET A 390
GLY A 391
 FAD  A 702 ( 3.7A)
None
None
None
 0.95A 4fo4A-3vrbA:
undetectable		 4fo4A-3vrbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 8 GLY A 254
THR A 257
MET A 390
GLY A 391
 None
 0.76A 4fo4B-3vrbA:
undetectable		 4fo4B-3vrbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 12 GLY A 391
GLY A 392
ASN A 431
LEU A 433
GLY A 109
 None
 1.05A 4fp9A-3vrbA:
undetectable		 4fp9A-3vrbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 12 GLY A 391
GLY A 392
ASN A 431
LEU A 433
GLY A 109
 None
 1.07A 4fp9C-3vrbA:
undetectable		 4fp9C-3vrbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 12 GLY A 391
GLY A 392
ASN A 431
LEU A 433
GLY A 109
 None
 1.05A 4fp9D-3vrbA:
undetectable		 4fp9D-3vrbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 12 GLY A 391
GLY A 392
ASN A 431
LEU A 433
GLY A 109
 None
 1.04A 4fp9F-3vrbA:
undetectable		 4fp9F-3vrbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 12 GLY A 391
GLY A 392
ASN A 431
LEU A 433
GLY A 109
 None
 1.07A 4fzvA-3vrbA:
undetectable		 4fzvA-3vrbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		3 / 4 SER A 141
GLY A 362
GLU B  91
 None
None
FAD  A 702 ( 4.4A)
 0.62A 4juoA-3vrbA:
undetectable
4juoC-3vrbA:
undetectable		 4juoA-3vrbA:
20.80
4juoC-3vrbA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 12 ASN A 252
ALA A  52
GLY A  50
ILE A 233
GLY A 445
 FAD  A 702 ( 3.7A)
FAD  A 702 (-4.0A)
FAD  A 702 (-3.0A)
None
None
 0.98A 4obwA-3vrbA:
undetectable		 4obwA-3vrbA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 12 GLY A  50
GLY A  51
GLY A 420
ALA A 441
ILE A 393
 FAD  A 702 (-3.0A)
FAD  A 702 (-4.4A)
FAD  A 702 (-3.6A)
FAD  A 702 ( 4.3A)
None
 0.99A 4rtmA-3vrbA:
undetectable		 4rtmA-3vrbA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 12 SER A 473
THR A 257
THR A 261
ALA A 260
ALA A 263
 None
 1.50A 4u15B-3vrbA:
undetectable		 4u15B-3vrbA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 6 ALA A 242
GLN A 497
MET A 553
LEU A 549
 None
 1.17A 4xoyA-3vrbA:
undetectable		 4xoyA-3vrbA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 4 VAL A 127
ALA A  89
ASN A  88
GLN A 150
 None
 1.40A 4zgfA-3vrbA:
undetectable		 4zgfA-3vrbA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		5 / 11 ARG A 320
GLY A 279
GLN A  84
GLU B  91
THR A 366
 FUM  A 701 (-3.2A)
None
None
FAD  A 702 ( 4.4A)
None
 1.39A 5b1bG-3vrbA:
undetectable
5b1bN-3vrbA:
1.7
5b1bO-3vrbA:
undetectable		 5b1bG-3vrbA:
8.69
5b1bN-3vrbA:
22.27
5b1bO-3vrbA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 6 LEU A 552
LEU A 549
SER A 546
THR A 544
 None
 1.07A 5bojA-3vrbA:
undetectable		 5bojA-3vrbA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		3 / 3 HIS A 250
SER A 541
ASN B  77
 None
 0.70A 5cprB-3vrbA:
undetectable		 5cprB-3vrbA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		4 / 5 TYR B 146
PRO A  75
GLY A 420
LEU A 184
 None
None
FAD  A 702 (-3.6A)
None
 1.00A 5eslA-3vrbB:
undetectable		 5eslA-3vrbB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		3 / 3 LEU A 433
TYR A 645
SER A 157
 None
 0.89A 5iktA-3vrbA:
undetectable		 5iktA-3vrbA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 12 SER A  78
THR A  80
ALA A 235
GLY A  53
ALA A  49
 FAD  A 702 (-2.9A)
FAD  A 702 (-3.4A)
None
None
FAD  A 702 (-3.9A)
 1.38A 5l5zH-3vrbA:
undetectable
5l5zI-3vrbA:
undetectable		 5l5zH-3vrbA:
17.77
5l5zI-3vrbA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 12 SER A  78
THR A  80
ALA A 235
GLY A  53
ALA A  49
 FAD  A 702 (-2.9A)
FAD  A 702 (-3.4A)
None
None
FAD  A 702 (-3.9A)
 1.37A 5l5zV-3vrbA:
undetectable
5l5zW-3vrbA:
undetectable		 5l5zV-3vrbA:
17.77
5l5zW-3vrbA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		5 / 11 ILE B 132
ILE A 538
VAL B 136
THR B  84
ASP A 534
 None
 1.04A 5lg3A-3vrbB:
undetectable		 5lg3A-3vrbB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		5 / 12 ILE B 132
ILE A 538
VAL B 136
THR B  84
ASP A 534
 None
 1.01A 5lg3E-3vrbB:
undetectable		 5lg3E-3vrbB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		5 / 10 ILE B 132
ILE A 538
VAL B 136
THR B  84
ASP A 534
 None
 1.04A 5lg3F-3vrbB:
undetectable		 5lg3F-3vrbB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		5 / 10 ILE B 132
ILE A 538
VAL B 136
THR B  84
ASP A 534
 None
 1.02A 5lg3G-3vrbB:
undetectable		 5lg3G-3vrbB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		5 / 10 ILE B 132
ILE A 538
VAL B 136
THR B  84
ASP A 534
 None
 1.05A 5lg3H-3vrbB:
undetectable		 5lg3H-3vrbB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		5 / 12 ILE B 132
ILE A 538
VAL B 136
THR B  84
ASP A 534
 None
 1.05A 5lg3J-3vrbB:
undetectable		 5lg3J-3vrbB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		3 / 3 HIS A 250
GLU A 545
ASN B  77
 None
 0.93A 5wbvA-3vrbA:
undetectable		 5wbvA-3vrbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		3 / 3 HIS A 250
GLU A 545
ASN B  77
 None
 0.93A 5wbvB-3vrbA:
undetectable		 5wbvB-3vrbA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		5 / 11 ARG A 320
GLY A 279
GLN A  84
GLU B  91
THR A 366
 FUM  A 701 (-3.2A)
None
None
FAD  A 702 ( 4.4A)
None
 1.48A 5x1fG-3vrbA:
undetectable
5x1fN-3vrbA:
0.8
5x1fO-3vrbA:
undetectable		 5x1fG-3vrbA:
8.69
5x1fN-3vrbA:
22.27
5x1fO-3vrbA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 6 PRO A 277
LEU A 317
ARG A 320
VAL A 323
 None
None
FUM  A 701 (-3.2A)
None
 0.98A 5x80A-3vrbA:
undetectable
5x80B-3vrbA:
undetectable		 5x80A-3vrbA:
13.58
5x80B-3vrbA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 6 TYR A 310
ILE A 329
GLU A 330
ARG A 335
 None
 0.70A 5z3jA-3vrbA:
undetectable		 5z3jA-3vrbA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		5 / 11 GLN A  84
GLU B  91
THR A 366
ARG A 320
GLY A 279
 None
FAD  A 702 ( 4.4A)
None
FUM  A 701 (-3.2A)
None
 1.44A 5z84A-3vrbA:
0.7
5z84B-3vrbA:
undetectable
5z84T-3vrbA:
undetectable		 5z84A-3vrbA:
22.27
5z84B-3vrbA:
15.62
5z84T-3vrbA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		5 / 11 GLN A  84
GLU B  91
THR A 366
ARG A 320
GLY A 279
 None
FAD  A 702 ( 4.4A)
None
FUM  A 701 (-3.2A)
None
 1.46A 5z86A-3vrbA:
undetectable
5z86B-3vrbA:
undetectable
5z86T-3vrbA:
undetectable		 5z86A-3vrbA:
22.27
5z86B-3vrbA:
15.62
5z86T-3vrbA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum;
Ascaris
suum) 		5 / 11 GLN A  84
GLU B  91
THR A 366
ARG A 320
GLY A 279
 None
FAD  A 702 ( 4.4A)
None
FUM  A 701 (-3.2A)
None
 1.43A 5zcqA-3vrbA:
0.0
5zcqB-3vrbA:
undetectable
5zcqT-3vrbA:
undetectable		 5zcqA-3vrbA:
22.27
5zcqB-3vrbA:
15.62
5zcqT-3vrbA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 7 LEU A  54
ALA A  56
ALA A  57
THR A  67
 None
 0.89A 6a7jA-3vrbA:
undetectable		 6a7jA-3vrbA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 5 THR A  71
THR A  81
HIS A 182
LEU A  54
 FAD  A 702 (-3.8A)
None
None
None
 1.37A 6aphA-3vrbA:
2.6		 6aphA-3vrbA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		3 / 3 HIS A 276
HIS A 387
ARG A 432
 FUM  A 701 (-4.3A)
FUM  A 701 ( 3.6A)
FUM  A 701 ( 2.3A)
 0.83A 6b58A-3vrbA:
50.4		 6b58A-3vrbA:
38.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3vrb IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		4 / 6 SER B 169
TYR B 167
GLN B 173
THR B 278
 None
 1.45A 6djzA-3vrbB:
undetectable		 6djzA-3vrbB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		5 / 12 ILE A 280
GLY A 284
THR A 248
ILE A 363
ILE A 287
 None
None
FAD  A 702 ( 4.9A)
None
None
 0.95A 6emuA-3vrbA:
2.1		 6emuA-3vrbA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 6 ILE A 287
LEU A 360
ARG A 151
SER A 291
 None
 0.93A 6f6jA-3vrbA:
undetectable		 6f6jA-3vrbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 5 THR A  71
THR A  81
HIS A 182
LEU A  54
 FAD  A 702 (-3.8A)
None
None
None
 1.40A 6gbnB-3vrbA:
undetectable		 6gbnB-3vrbA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 3vrb IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		4 / 8 VAL B 131
TYR B  41
ASN B  44
GLU B  46
 None
 1.22A 6gneB-3vrbB:
undetectable		 6gneB-3vrbB:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II
(Ascaris
suum) 		4 / 6 TYR A  35
ILE A 474
ALA A 479
ARG A 481
 None
 1.05A 6hu9m-3vrbA:
undetectable
6hu9q-3vrbA:
undetectable		 6hu9m-3vrbA:
23.24
6hu9q-3vrbA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 3vrb IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE
(Ascaris
suum) 		3 / 3 TRP B 214
ILE B 216
ASP B 217
 None
 0.81A 6i0y7-3vrbB:
undetectable		 6i0y7-3vrbB:
6.40