SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vre'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 3vre HEMOGLOBIN SUBUNIT
ALPHA
(Mammuthus
primigenius) 		4 / 5 GLY A  63
LEU A  66
THR A  67
VAL A  25
 None
 1.07A 1ekjF-3vreA:
undetectable
1ekjG-3vreA:
undetectable		 1ekjF-3vreA:
22.42
1ekjG-3vreA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		5 / 11 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.45A 1fkpA-3vreB:
undetectable		 1fkpA-3vreB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 3vre HEMOGLOBIN SUBUNIT
ALPHA
(Mammuthus
primigenius) 		4 / 7 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 201 (-3.7A)
HEM  A 201 (-4.4A)
HEM  A 201 (-4.2A)
HEM  A 201 (-3.4A)
 0.97A 1lh6A-3vreA:
13.2		 1lh6A-3vreA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		4 / 7 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 201 (-4.4A)
None
HEM  B 201 (-3.8A)
HEM  B 201 (-3.4A)
 0.90A 1lh6A-3vreB:
13.8		 1lh6A-3vreB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		5 / 10 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.39A 1lw0A-3vreB:
undetectable		 1lw0A-3vreB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		5 / 11 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.44A 1lwcA-3vreB:
undetectable		 1lwcA-3vreB:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		5 / 9 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.36A 1vrtA-3vreB:
undetectable		 1vrtA-3vreB:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 3vre HEMOGLOBIN SUBUNIT
ALPHA
(Mammuthus
primigenius) 		5 / 10 ALA A  69
LEU A  76
SER A  84
LEU A 136
VAL A 135
 None
 1.14A 2bxeA-3vreA:
2.0		 2bxeA-3vreA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 3vre HEMOGLOBIN SUBUNIT
ALPHA
(Mammuthus
primigenius) 		5 / 11 VAL A  25
GLY A  59
ALA A  28
LEU A 105
SER A 133
 None
None
None
None
HEM  A 201 ( 4.2A)
 1.27A 2bxgA-3vreA:
2.7		 2bxgA-3vreA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 3vre HEMOGLOBIN SUBUNIT
ALPHA
(Mammuthus
primigenius) 		6 / 10 ALA A  69
LEU A  73
LEU A  76
SER A  84
LEU A 136
VAL A 135
 None
 1.46A 2bxgB-3vreA:
2.1		 2bxgB-3vreA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		5 / 10 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.43A 2hndA-3vreB:
undetectable		 2hndA-3vreB:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		5 / 10 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.44A 2hnyA-3vreB:
undetectable		 2hnyA-3vreB:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 3vre HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		4 / 8 ARG A  31
HIS A 112
SER A 111
ALA B 115
 None
 1.22A 2rk8A-3vreA:
3.6		 2rk8A-3vreA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		5 / 10 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.48A 3lp1A-3vreB:
undetectable		 3lp1A-3vreB:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		5 / 10 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.41A 3qipA-3vreB:
undetectable		 3qipA-3vreB:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3vre HEMOGLOBIN SUBUNIT
ALPHA
(Mammuthus
primigenius) 		4 / 6 LEU A 105
TYR A  24
ALA A  26
LEU A 109
 None
 1.09A 3ravA-3vreA:
undetectable		 3ravA-3vreA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 3vre HEMOGLOBIN SUBUNIT
ALPHA
(Mammuthus
primigenius) 		4 / 5 ASN A 131
LEU A  76
SER A 133
LEU A  66
 None
None
HEM  A 201 ( 4.2A)
None
 1.30A 4n09C-3vreA:
undetectable		 4n09C-3vreA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		4 / 4 VAL B 134
GLU B 131
GLY B 107
LEU B 110
 None
 1.22A 5g5gC-3vreB:
undetectable		 5g5gC-3vreB:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		5 / 11 LEU B  68
VAL B 134
VAL B 109
TYR B 130
GLY B 107
 None
 1.38A 5hbmA-3vreB:
undetectable		 5hbmA-3vreB:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 3vre HEMOGLOBIN SUBUNIT
ALPHA
(Mammuthus
primigenius) 		4 / 4 ASN A 131
LEU A  76
SER A 133
LEU A  66
 None
None
HEM  A 201 ( 4.2A)
None
 1.24A 5kb5A-3vreA:
undetectable		 5kb5A-3vreA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		4 / 6 ASP B  47
LEU B  48
GLY B  46
PHE B  45
 None
 0.95A 5nooC-3vreB:
undetectable		 5nooC-3vreB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		4 / 4 VAL B 133
VAL B 134
TYR B 130
GLN B 127
 None
 1.16A 5qggA-3vreB:
undetectable		 5qggA-3vreB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		4 / 4 VAL B 133
VAL B 134
TYR B 130
GLN B 127
 None
 1.14A 5qgoA-3vreB:
undetectable		 5qgoA-3vreB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		4 / 4 VAL B 133
VAL B 134
TYR B 130
GLN B 127
 None
 1.14A 5qgpA-3vreB:
undetectable		 5qgpA-3vreB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		4 / 4 VAL B 133
VAL B 134
TYR B 130
GLN B 127
 None
 1.19A 5qgqA-3vreB:
undetectable		 5qgqA-3vreB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		4 / 4 VAL B 133
VAL B 134
TYR B 130
GLN B 127
 None
 1.17A 5qhbA-3vreB:
undetectable		 5qhbA-3vreB:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3vre HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		5 / 8 PRO A  95
THR A 134
THR A 137
TYR A 140
TRP B  37
 None
 0.89A 5x2sI-3vreA:
26.4
5x2sJ-3vreA:
21.4
5x2sK-3vreA:
27.3		 5x2sI-3vreA:
82.98
5x2sJ-3vreA:
40.94
5x2sK-3vreA:
82.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3vre HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		4 / 8 PRO A  95
THR A 134
THR A 137
TRP B  37
 None
 0.65A 5x2tI-3vreA:
26.5
5x2tJ-3vreA:
21.5
5x2tK-3vreA:
27.2
5x2tL-3vreA:
20.2		 5x2tI-3vreA:
82.98
5x2tJ-3vreA:
40.94
5x2tK-3vreA:
82.98
5x2tL-3vreA:
40.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		5 / 10 TYR B 130
ALA B 129
LEU B  78
VAL B   1
GLY B 136
 None
 1.39A 5zbdA-3vreB:
undetectable		 5zbdA-3vreB:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		5 / 9 VAL B 111
VAL B 137
LEU B 114
GLY B  72
LEU B  68
 None
 1.29A 6czmB-3vreB:
undetectable
6czmC-3vreB:
undetectable		 6czmB-3vreB:
18.18
6czmC-3vreB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3vre HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		5 / 9 VAL B 111
VAL B 137
LEU B 114
GLY B  72
LEU B  68
 None
 1.28A 6czmD-3vreB:
undetectable
6czmE-3vreB:
undetectable		 6czmD-3vreB:
18.18
6czmE-3vreB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 3vre HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID
(Mammuthus
primigenius) 		5 / 12 GLY B  24
GLY B  25
LEU B  28
GLU B 131
PRO A 119
 None
 1.06A 6gngB-3vreB:
undetectable		 6gngB-3vreB:
14.48