SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vrh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300
(Pyrococcus
horikoshii) 		5 / 11 SER A  55
SER A  60
THR A 153
GLY A 154
HIS A 155
 BCN  A 403 (-2.9A)
BCN  A 403 (-2.6A)
BCN  A 403 (-4.1A)
BCN  A 403 (-3.7A)
BCN  A 403 ( 3.9A)
 0.45A 2hmaA-3vrhA:
10.4		 2hmaA-3vrhA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300
(Pyrococcus
horikoshii) 		4 / 6 LEU A 164
SER A 162
ASP A 159
ASP A 158
 None
None
BCN  A 403 (-3.7A)
None
 1.24A 2j2pE-3vrhA:
undetectable
2j2pF-3vrhA:
undetectable		 2j2pE-3vrhA:
20.13
2j2pF-3vrhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300
(Pyrococcus
horikoshii) 		3 / 3 ASP A 158
ASN A 156
THR A  37
 None
 0.79A 2q63B-3vrhA:
undetectable		 2q63B-3vrhA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300
(Pyrococcus
horikoshii) 		4 / 8 VAL A  34
VAL A 204
ILE A  74
VAL A  52
 None
 0.71A 3hjoB-3vrhA:
undetectable		 3hjoB-3vrhA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300
(Pyrococcus
horikoshii) 		5 / 12 ASN A  80
ILE A 138
THR A 134
ILE A 296
ILE A 113
 None
 1.06A 3kpbA-3vrhA:
undetectable		 3kpbA-3vrhA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300
(Pyrococcus
horikoshii) 		4 / 8 GLY A  56
LYS A  89
SER A  90
TYR A  93
 None
 0.67A 3u9hA-3vrhA:
undetectable		 3u9hA-3vrhA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300
(Pyrococcus
horikoshii) 		4 / 8 GLY A  56
LYS A  89
SER A  90
TYR A  93
 None
 0.68A 3u9hB-3vrhA:
undetectable		 3u9hB-3vrhA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300
(Pyrococcus
horikoshii) 		5 / 12 LEU A 114
SER A 301
SER A 302
PHE A 142
ASN A 146
 None
 1.41A 4amjB-3vrhA:
undetectable		 4amjB-3vrhA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300
(Pyrococcus
horikoshii) 		4 / 8 GLY A  56
LYS A  89
SER A  90
TYR A  93
 None
 0.68A 4bjcA-3vrhA:
undetectable		 4bjcA-3vrhA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300
(Pyrococcus
horikoshii) 		4 / 8 GLY A  56
LYS A  89
SER A  90
TYR A  93
 None
 0.73A 4hyfB-3vrhA:
undetectable		 4hyfB-3vrhA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300
(Pyrococcus
horikoshii) 		4 / 5 TYR A  16
LYS A  33
TYR A  29
GLU A 239
 None
 1.20A 4x61A-3vrhA:
2.1		 4x61A-3vrhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300
(Pyrococcus
horikoshii) 		3 / 3 GLU A 160
THR A 153
HIS A 155
 None
BCN  A 403 (-4.1A)
BCN  A 403 ( 3.9A)
 0.83A 4ydqB-3vrhA:
2.1		 4ydqB-3vrhA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300
(Pyrococcus
horikoshii) 		4 / 6 TYR A  16
LYS A  33
TYR A  29
GLU A 239
 None
 1.28A 5emlA-3vrhA:
undetectable		 5emlA-3vrhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3vrh PUTATIVE
UNCHARACTERIZED
PROTEIN PH0300
(Pyrococcus
horikoshii) 		4 / 8 THR A  45
ILE A  50
PRO A 195
LEU A  67
 None
 0.83A 5g48A-3vrhA:
undetectable		 5g48A-3vrhA:
21.48