SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vs8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		4 / 4 LEU A 404
MET A 199
ILE A 247
ASP A  14
 None
 1.42A 3hecA-3vs8A:
undetectable		 3hecA-3vs8A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		5 / 12 VAL A 307
GLY A 403
ALA A 401
ILE A 376
TYR A 380
 None
 1.04A 3mb5A-3vs8A:
undetectable		 3mb5A-3vs8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		3 / 3 LYS A 339
SER A  70
GLN A  73
 None
 1.03A 3si7A-3vs8A:
undetectable		 3si7A-3vs8A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		6 / 11 ALA A 332
VAL A 405
GLY A 403
ALA A 402
TYR A 249
LEU A 377
 None
 1.29A 3sm2B-3vs8A:
undetectable		 3sm2B-3vs8A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		5 / 12 LEU A 377
ALA A 189
LEU A 404
MET A 270
ILE A 267
 None
 1.22A 3ut5D-3vs8A:
undetectable		 3ut5D-3vs8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		4 / 8 ASP A  92
ASN A  94
GLU A  50
ASP A  96
 None
 0.99A 4feuF-3vs8A:
undetectable		 4feuF-3vs8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		4 / 7 ASP A  92
ASN A  94
GLU A  50
ASP A  96
 None
 1.04A 4fexB-3vs8A:
undetectable		 4fexB-3vs8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		4 / 8 ASP A  92
ASN A  94
GLU A  50
ASP A  96
 None
 0.97A 4gkhB-3vs8A:
undetectable		 4gkhB-3vs8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		4 / 8 ASP A  92
ASN A  94
GLU A  50
ASP A  96
 None
 1.01A 4gkhF-3vs8A:
undetectable		 4gkhF-3vs8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		3 / 3 LEU A 241
MET A 293
TYR A  67
 None
 0.93A 4p6xG-3vs8A:
undetectable		 4p6xG-3vs8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		5 / 12 LEU A 377
ILE A 267
ILE A 373
ALA A 189
PHE A 190
 None
 0.78A 4rp8C-3vs8A:
undetectable		 4rp8C-3vs8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		4 / 7 LYS A  75
LEU A 363
GLU A 364
SER A 360
 None
 1.09A 4tvtA-3vs8A:
undetectable		 4tvtA-3vs8A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		3 / 3 ASN A 227
PHE A 110
TYR A  81
 None
 0.87A 4u15A-3vs8A:
undetectable		 4u15A-3vs8A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		5 / 11 LEU A 377
LEU A 404
MET A 270
VAL A 251
ILE A 267
 None
 1.16A 4x20D-3vs8A:
undetectable		 4x20D-3vs8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		4 / 5 ALA A 401
THR A 400
TYR A 187
HIS A 273
 None
NA  A 501 ( 4.2A)
NA  A 501 (-4.6A)
None
 1.36A 5ecmA-3vs8A:
undetectable		 5ecmA-3vs8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		4 / 7 ALA A 401
THR A 400
TYR A 187
HIS A 273
 None
NA  A 501 ( 4.2A)
NA  A 501 (-4.6A)
None
 1.21A 5ecnA-3vs8A:
undetectable		 5ecnA-3vs8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		5 / 12 VAL A 178
ALA A 164
MET A 167
VAL A 168
GLY A 135
 None
 1.02A 5igiA-3vs8A:
undetectable		 5igiA-3vs8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		5 / 12 VAL A 178
ALA A 164
MET A 167
VAL A 168
GLY A 135
 None
 0.98A 5igjA-3vs8A:
undetectable		 5igjA-3vs8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		5 / 12 ASN A 235
VAL A  69
LEU A  30
THR A  29
THR A  33
 None
 1.25A 5jnaB-3vs8A:
undetectable		 5jnaB-3vs8A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		5 / 11 ASN A 235
VAL A  69
LEU A  30
THR A  29
THR A  33
 None
 1.22A 5jnaC-3vs8A:
undetectable		 5jnaC-3vs8A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		4 / 5 VAL A 168
THR A 176
ASP A 215
LEU A 150
 None
 1.07A 5m0iB-3vs8A:
undetectable		 5m0iB-3vs8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		4 / 8 ASN A 365
PHE A 362
THR A  29
ILE A  74
 None
 0.99A 5nzxA-3vs8A:
undetectable		 5nzxA-3vs8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 3vs8 TYPE III POLYKETIDE
SYNTHASE
(Azotobacter
vinelandii) 		5 / 11 THR A 143
GLU A 141
PHE A 140
ALA A 217
LEU A  12
 None
 1.29A 6efnA-3vs8A:
undetectable		 6efnA-3vs8A:
23.06