SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vsc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 6 GLN A 224
ASP A 150
VAL A 173
HIS A 221
 SEP  A 402 (-3.3A)
None
None
None
 1.39A 1ekjG-3vscA:
undetectable
1ekjH-3vscA:
undetectable		 1ekjG-3vscA:
19.29
1ekjH-3vscA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 6 ALA A  55
SER A  15
ARG A  35
LEU A  71
 None
 1.13A 1gahA-3vscA:
undetectable		 1gahA-3vscA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		5 / 11 GLY A 261
HIS A 234
SER A 153
GLY A 258
ILE A 242
 SEP  A 402 ( 2.9A)
None
SEP  A 402 (-2.9A)
None
None
 1.24A 1jzsA-3vscA:
undetectable		 1jzsA-3vscA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		5 / 12 PRO A 287
ILE A 338
GLY A 342
VAL A 365
ALA A 348
 None
 0.94A 1nv8A-3vscA:
4.0		 1nv8A-3vscA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 5 GLY A 261
ILE A 296
VAL A 126
SER A 259
 SEP  A 402 ( 2.9A)
PLP  A 401 (-4.6A)
None
PLP  A 401 (-3.4A)
 0.81A 1rs7A-3vscA:
undetectable		 1rs7A-3vscA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 6 GLY A 261
ILE A 296
VAL A 126
SER A 259
 SEP  A 402 ( 2.9A)
PLP  A 401 (-4.6A)
None
PLP  A 401 (-3.4A)
 0.93A 1rs7B-3vscA:
undetectable		 1rs7B-3vscA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		5 / 12 PRO A 287
ILE A 338
GLY A 342
VAL A 365
ALA A 348
 None
 0.94A 1sg9B-3vscA:
3.4		 1sg9B-3vscA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		3 / 3 SER A 123
THR A 262
GLN A 224
 None
PLP  A 401 ( 2.7A)
SEP  A 402 (-3.3A)
 0.83A 2fk8A-3vscA:
3.4		 2fk8A-3vscA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		5 / 11 TYR A  21
ALA A  25
ILE A  53
LEU A  10
ILE A  58
 None
 1.25A 2h42A-3vscA:
undetectable		 2h42A-3vscA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		3 / 3 GLY A 145
TYR A 169
SER A 146
 None
 0.68A 2xatA-3vscA:
undetectable		 2xatA-3vscA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 5 GLY A 261
ILE A 296
VAL A 126
SER A 259
 SEP  A 402 ( 2.9A)
PLP  A 401 (-4.6A)
None
PLP  A 401 (-3.4A)
 0.99A 4d33A-3vscA:
undetectable		 4d33A-3vscA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 5 GLY A 261
ILE A 296
VAL A 126
SER A 259
 SEP  A 402 ( 2.9A)
PLP  A 401 (-4.6A)
None
PLP  A 401 (-3.4A)
 0.99A 4d33B-3vscA:
undetectable		 4d33B-3vscA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 6 GLY A 261
ILE A 296
VAL A 126
SER A 259
 SEP  A 402 ( 2.9A)
PLP  A 401 (-4.6A)
None
PLP  A 401 (-3.4A)
 0.95A 4d39B-3vscA:
undetectable		 4d39B-3vscA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 6 GLY A 261
ILE A 296
VAL A 126
SER A 259
 SEP  A 402 ( 2.9A)
PLP  A 401 (-4.6A)
None
PLP  A 401 (-3.4A)
 0.84A 4kcnA-3vscA:
undetectable		 4kcnA-3vscA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 5 VAL A 276
LEU A  68
VAL A  73
PHE A 243
 None
 0.94A 4lb0B-3vscA:
undetectable		 4lb0B-3vscA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		5 / 12 LEU A 273
LEU A 253
GLY A 255
LEU A 349
VAL A 366
 None
 1.24A 4olmA-3vscA:
undetectable		 4olmA-3vscA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		5 / 9 PRO A 368
LEU A 114
MET A 266
SER A 259
VAL A 346
 PLP  A 401 (-4.1A)
None
None
PLP  A 401 (-3.4A)
None
 1.49A 4x3mA-3vscA:
undetectable		 4x3mA-3vscA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 7 ALA A 233
GLU A  92
GLY A 237
GLY A  54
 None
 0.87A 5e26A-3vscA:
2.8
5e26B-3vscA:
2.5		 5e26A-3vscA:
22.10
5e26B-3vscA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 7 GLU A  92
GLY A 237
GLY A  54
ALA A 233
 None
 0.84A 5e26C-3vscA:
2.5
5e26D-3vscA:
2.3		 5e26C-3vscA:
22.10
5e26D-3vscA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		3 / 3 ILE A 293
PRO A 294
ILE A 296
 None
None
PLP  A 401 (-4.6A)
 0.33A 5hw8F-3vscA:
undetectable		 5hw8F-3vscA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 5 PRO A  96
HIS A 234
LEU A  29
TYR A  51
 None
 1.48A 5igjA-3vscA:
undetectable		 5igjA-3vscA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 6 ILE A 280
TYR A 363
VAL A 256
SER A 246
 None
 0.94A 5jwaH-3vscA:
2.3		 5jwaH-3vscA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 8 PRO A 368
GLY A 339
PRO A 340
ASP A 369
 PLP  A 401 (-4.1A)
None
None
PLP  A 401 (-3.5A)
 1.05A 5kf8A-3vscA:
undetectable		 5kf8A-3vscA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 8 PRO A 368
GLY A 339
PRO A 340
ASP A 369
 PLP  A 401 (-4.1A)
None
None
PLP  A 401 (-3.5A)
 1.03A 5kgpA-3vscA:
undetectable		 5kgpA-3vscA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 8 PRO A 368
GLY A 339
PRO A 340
ASP A 369
 PLP  A 401 (-4.1A)
None
None
PLP  A 401 (-3.5A)
 1.02A 5kgpB-3vscA:
undetectable		 5kgpB-3vscA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		5 / 12 ILE A 135
ILE A 134
VAL A 163
ASN A 155
ALA A 233
 None
None
None
PLP  A 401 ( 3.7A)
None
 1.10A 5lg3E-3vscA:
undetectable		 5lg3E-3vscA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LUR_B_STRB201_1
(AVIDIN)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		5 / 11 HIS A 234
ALA A 233
VAL A 132
PHE A  91
THR A  97
 None
 1.42A 5lurB-3vscA:
0.0		 5lurB-3vscA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		3 / 3 THR A  97
GLU A 241
HIS A 234
 None
 0.91A 5xioA-3vscA:
2.7		 5xioA-3vscA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		3 / 3 THR A  97
GLU A 241
HIS A 234
 None
 0.91A 5xiqB-3vscA:
undetectable		 5xiqB-3vscA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		3 / 3 THR A  97
GLU A 241
HIS A 234
 None
 0.92A 5xiqD-3vscA:
2.6		 5xiqD-3vscA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 7 SER A 341
SER A 259
HIS A 265
GLY A 258
 PLP  A 401 (-2.6A)
PLP  A 401 (-3.4A)
PLP  A 401 (-3.9A)
None
 1.08A 6btxA-3vscA:
undetectable		 6btxA-3vscA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 8 ILE A 280
GLN A 274
ILE A 242
THR A 238
 None
 0.98A 6cduG-3vscA:
undetectable
6cduH-3vscA:
undetectable		 6cduG-3vscA:
23.54
6cduH-3vscA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3vsc PROTEIN CYSO
(Aeropyrum
pernix) 		4 / 8 VAL A 126
ASN A 120
GLN A 245
GLU A 241
 None
 1.05A 6hzpA-3vscA:
undetectable		 6hzpA-3vscA:
23.23