SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vse'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
4 / 8 TYR A  66
VAL A  63
HIS A 372
GLY A  17
None
0.91A 1ekjA-3vseA:
3.0
1ekjB-3vseA:
3.0
1ekjA-3vseA:
21.16
1ekjB-3vseA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
4 / 7 ALA A 227
TYR A 185
SER A 234
ALA A 232
SAH  A 401 ( 4.7A)
None
None
None
0.94A 1k5qA-3vseA:
undetectable
1k5qB-3vseA:
undetectable
1k5qA-3vseA:
22.29
1k5qB-3vseA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
5 / 12 GLU A  23
ARG A  55
ILE A  21
ILE A  40
TYR A  14
None
1.01A 1kijB-3vseA:
undetectable
1kijB-3vseA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
3 / 3 ARG A 205
ASP A 243
ASP A 272
None
SAH  A 401 (-2.7A)
SAH  A 401 (-3.0A)
0.72A 2ejtA-3vseA:
14.3
2ejtA-3vseA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
5 / 12 ILE A  21
GLY A  61
GLY A  54
LEU A  32
ALA A  51
None
0.98A 2fk8A-3vseA:
13.3
2fk8A-3vseA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
3 / 3 ASP A 243
ASP A 272
ASP A 293
SAH  A 401 (-2.7A)
SAH  A 401 (-3.0A)
SAH  A 401 (-3.2A)
0.52A 2igtA-3vseA:
25.0
2igtA-3vseA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
3 / 3 ASP A 243
ASP A 272
ASP A 293
SAH  A 401 (-2.7A)
SAH  A 401 (-3.0A)
SAH  A 401 (-3.2A)
0.58A 2igtB-3vseA:
24.8
2igtB-3vseA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
3 / 3 TYR A 152
GLY A 164
PHE A 166
None
0.63A 2m2pB-3vseA:
undetectable
2m2pB-3vseA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
4 / 5 ALA A 227
ASP A 243
ASP A 272
ASP A 293
SAH  A 401 ( 4.7A)
SAH  A 401 (-2.7A)
SAH  A 401 (-3.0A)
SAH  A 401 (-3.2A)
0.71A 2nyuB-3vseA:
14.9
2nyuB-3vseA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
4 / 5 LEU A 314
GLY A 317
ILE A 290
ILE A 292
None
0.74A 2q9rA-3vseA:
undetectable
2q9rA-3vseA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
3 / 3 ASP A 243
ASP A 272
ASP A 293
SAH  A 401 (-2.7A)
SAH  A 401 (-3.0A)
SAH  A 401 (-3.2A)
0.73A 3douA-3vseA:
13.8
3douA-3vseA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
4 / 7 THR A 327
VAL A 291
THR A 289
VAL A 218
None
0.60A 3em0B-3vseA:
undetectable
3em0B-3vseA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
5 / 12 PHE A  77
GLU A 106
GLY A 111
PHE A 134
GLY A 109
None
1.32A 3ps9A-3vseA:
3.6
3ps9A-3vseA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA802_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
5 / 9 PHE A 222
TYR A 224
ASP A 243
ASP A 272
PRO A 295
SAH  A 401 (-4.3A)
SAH  A 401 (-4.8A)
SAH  A 401 (-2.7A)
SAH  A 401 (-3.0A)
SAH  A 401 ( 4.2A)
0.51A 3v8vA-3vseA:
15.9
3v8vA-3vseA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB802_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
6 / 12 ARG A 205
PHE A 222
TYR A 224
ASP A 272
ASP A 293
PRO A 295
None
SAH  A 401 (-4.3A)
SAH  A 401 (-4.8A)
SAH  A 401 (-3.0A)
SAH  A 401 (-3.2A)
SAH  A 401 ( 4.2A)
0.37A 3v8vB-3vseA:
31.3
3v8vB-3vseA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
3 / 3 ARG A 205
ASP A 116
GLN A 125
None
0.81A 4azsA-3vseA:
13.3
4azsA-3vseA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
3 / 3 TYR A 118
THR A 195
GLU A 180
None
0.76A 4df3A-3vseA:
14.4
4df3A-3vseA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
3 / 3 TYR A 118
THR A 195
GLU A 180
None
0.77A 4df3B-3vseA:
14.3
4df3B-3vseA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DMG_A_SAMA401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
5 / 12 ARG A 205
TYR A 224
ASP A 243
ASP A 293
PRO A 295
None
SAH  A 401 (-4.8A)
SAH  A 401 (-2.7A)
SAH  A 401 (-3.2A)
SAH  A 401 ( 4.2A)
0.61A 4dmgA-3vseA:
39.6
4dmgA-3vseA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DMG_B_SAMB401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
5 / 11 ARG A 205
TYR A 224
ASP A 243
ASP A 293
PRO A 295
None
SAH  A 401 (-4.8A)
SAH  A 401 (-2.7A)
SAH  A 401 (-3.2A)
SAH  A 401 ( 4.2A)
0.68A 4dmgB-3vseA:
39.8
4dmgB-3vseA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
5 / 12 PHE A 256
GLU A 180
ASN A 181
ARG A 209
LEU A 208
None
1.42A 4k39A-3vseA:
undetectable
4k39A-3vseA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
3 / 3 ARG A 209
LYS A 207
LYS A 206
None
1.26A 4k50A-3vseA:
undetectable
4k50A-3vseA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
3 / 3 ARG A 209
LYS A 207
LYS A 206
None
1.26A 4k50E-3vseA:
undetectable
4k50E-3vseA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
3 / 3 ARG A 209
LYS A 207
LYS A 206
None
1.25A 4k50I-3vseA:
undetectable
4k50I-3vseA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
4 / 8 TYR A  14
ILE A  26
ILE A  40
ALA A  51
None
0.97A 4ou1A-3vseA:
undetectable
4ou1A-3vseA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
3 / 3 ASN A 181
PHE A 100
TYR A 118
None
0.82A 4u15A-3vseA:
undetectable
4u15A-3vseA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
5 / 12 GLU A  23
ARG A  55
ILE A  21
ALA A  51
ILE A  40
None
0.93A 4uroC-3vseA:
undetectable
4uroC-3vseA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
4 / 9 PHE A  15
VAL A  63
ASP A  25
ILE A  40
None
1.05A 5lg3I-3vseA:
undetectable
5lg3I-3vseA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
4 / 7 PHE A 134
LEU A  64
THR A  65
THR A  50
None
0.88A 5m78A-3vseA:
undetectable
5m78A-3vseA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
5 / 9 ALA A 137
ILE A 115
LEU A 113
ILE A 124
ILE A 151
None
1.00A 5nunA-3vseA:
undetectable
5nunA-3vseA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
4 / 6 ALA A 171
PRO A 172
PHE A 174
GLU A 190
None
1.32A 5odqA-3vseA:
3.3
5odqA-3vseA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
4 / 6 ARG A  55
LEU A  60
PHE A  38
LEU A  32
None
1.15A 5x19P-3vseA:
undetectable
5x19P-3vseA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
3 / 3 LYS A 382
ASN A 333
SER A 296
None
1.15A 5yw0A-3vseA:
undetectable
5yw0A-3vseA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus)
4 / 5 LEU A 339
ILE A 290
MET A 363
GLY A 364
None
1.05A 6hd6A-3vseA:
undetectable
6hd6A-3vseA:
11.98