SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vsz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 GLU A 199
ALA A 197
SER A 195
HIS A 130
 None
 1.13A 1errA-3vszA:
undetectable
1errB-3vszA:
undetectable		 1errA-3vszA:
17.42
1errB-3vszA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A 158
VAL A 126
TRP A 128
 None
 1.12A 1qw6A-3vszA:
undetectable		 1qw6A-3vszA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A 158
VAL A 126
TRP A 128
 None
 1.18A 1qwcA-3vszA:
undetectable		 1qwcA-3vszA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A 158
VAL A 126
TRP A 128
 None
 1.16A 1vagA-3vszA:
undetectable		 1vagA-3vszA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A 158
VAL A 126
TRP A 128
 None
 1.19A 1zviA-3vszA:
undetectable		 1zviA-3vszA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 259
TYR A 271
TYR A 257
PHE A 223
 None
 1.18A 2ajvH-3vszA:
undetectable
2ajvL-3vszA:
undetectable		 2ajvH-3vszA:
17.69
2ajvL-3vszA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ARG A 113
GLU A 229
ASN A 253
ALA A 255
 None
 1.32A 2ejgB-3vszA:
undetectable		 2ejgB-3vszA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TRP A 304
GLY A 301
THR A 284
SER A 245
 None
 1.03A 2o5yH-3vszA:
undetectable
2o5yL-3vszA:
undetectable		 2o5yH-3vszA:
18.62
2o5yL-3vszA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLN A 393
GLN A 430
ASP A 369
SER A 389
 None
 1.18A 2xz5C-3vszA:
undetectable
2xz5D-3vszA:
undetectable		 2xz5C-3vszA:
16.57
2xz5D-3vszA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A 207
ASP A 186
TYR A 240
 None
 0.72A 2yvlB-3vszA:
undetectable		 2yvlB-3vszA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 LEU A  98
SER A  99
ILE A 111
CYH A 109
 None
 0.97A 3ko0B-3vszA:
undetectable		 3ko0B-3vszA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ARG A  94
GLY A 123
PHE A 125
THR A 149
ASP A 151
 None
 0.95A 3sugA-3vszA:
undetectable		 3sugA-3vszA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLY A 138
GLU A 132
ASN A 200
GLU A 229
 None
 1.00A 3vywC-3vszA:
undetectable		 3vywC-3vszA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASN A 133
GLU A 132
ARG A 141
 None
 1.09A 3wxoA-3vszA:
undetectable		 3wxoA-3vszA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		5 / 10 TYR A 334
LEU A 320
ALA A 230
ALA A 255
GLY A 301
 None
 1.14A 4rn6A-3vszA:
undetectable		 4rn6A-3vszA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A 151
ARG A  94
TRP A  66
TRP A 319
 None
 1.21A 4uhxA-3vszA:
undetectable		 4uhxA-3vszA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 257
TYR A 241
LEU A 233
PHE A 184
 None
 1.13A 4yv5A-3vszA:
undetectable		 4yv5A-3vszA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 257
TYR A 241
LEU A 233
PHE A 184
 None
 1.15A 4yv5B-3vszA:
undetectable		 4yv5B-3vszA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ARG A 158
VAL A 126
TRP A 128
 None
 1.17A 5fvoA-3vszA:
undetectable		 5fvoA-3vszA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLY A 175
ILE A 157
ARG A 158
TYR A 206
 None
 1.05A 5iwuA-3vszA:
undetectable		 5iwuA-3vszA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 LEU A 205
TYR A 192
THR A 187
LEU A 222
 None
 1.06A 5jq7B-3vszA:
undetectable		 5jq7B-3vszA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 VAL A 183
ARG A  84
PRO A 150
 None
 0.66A 5koxA-3vszA:
undetectable		 5koxA-3vszA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 VAL A 185
ARG A  84
PRO A 150
 None
 0.74A 5koxA-3vszA:
undetectable		 5koxA-3vszA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 GLY A  61
ASP A  62
ARG A  84
MET A 300
 None
 1.50A 5zrfB-3vszA:
undetectable		 5zrfB-3vszA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		4 / 4 GLY A  61
ASP A  62
ARG A  84
MET A 300
 None
 1.45A 5zrfA-3vszA:
undetectable		 5zrfA-3vszA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ASN A 200
TYR A 176
GLY A 175
ASP A 202
 None
 1.22A 6gh9A-3vszA:
undetectable		 6gh9A-3vszA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3vsz RICIN B LECTIN
(Ruminiclostridiu
m
thermocellum) 		5 / 10 SER A 178
TYR A 206
GLY A 191
ALA A 120
VAL A 183
 None
 1.47A 6hu9L-3vszA:
undetectable
6hu9P-3vszA:
undetectable
6hu9T-3vszA:
undetectable		 6hu9L-3vszA:
22.00
6hu9P-3vszA:
16.16
6hu9T-3vszA:
9.09