SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vta'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)
3vta CUCUMISIN
(Cucumis
melo)
4 / 7 THR A 353
SER A 428
TYR A 223
GLN A 357
None
1.36A 1eiiA-3vtaA:
undetectable
1eiiA-3vtaA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)
3vta CUCUMISIN
(Cucumis
melo)
4 / 8 PHE A 518
VAL A 217
GLY A 214
GLY A 215
None
0.64A 1ekjE-3vtaA:
undetectable
1ekjF-3vtaA:
undetectable
1ekjE-3vtaA:
16.75
1ekjF-3vtaA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)
3vta CUCUMISIN
(Cucumis
melo)
5 / 12 ARG A 127
ILE A 134
ILE A 269
ALA A 583
ARG A 585
None
1.14A 2j0dA-3vtaA:
undetectable
2j0dA-3vtaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)
3vta CUCUMISIN
(Cucumis
melo)
5 / 12 PRO A 454
ILE A 394
LEU A 361
THR A 336
LEU A 436
None
1.13A 3a50D-3vtaA:
undetectable
3a50D-3vtaA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)
3vta CUCUMISIN
(Cucumis
melo)
5 / 11 ALA A 230
LEU A 216
PRO A 235
GLY A 214
SER A 210
None
1.00A 3bpxA-3vtaA:
undetectable
3bpxB-3vtaA:
undetectable
3bpxA-3vtaA:
11.64
3bpxB-3vtaA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)
3vta CUCUMISIN
(Cucumis
melo)
5 / 12 ALA A 569
GLU A 570
SER A 729
ILE A 703
LEU A 675
None
1.21A 3ia4A-3vtaA:
undetectable
3ia4A-3vtaA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)
3vta CUCUMISIN
(Cucumis
melo)
5 / 12 ALA A 569
GLU A 570
SER A 729
ILE A 703
LEU A 675
None
1.21A 3ia4B-3vtaA:
undetectable
3ia4B-3vtaA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)
3vta CUCUMISIN
(Cucumis
melo)
5 / 12 ALA A 569
GLU A 570
SER A 729
ILE A 703
LEU A 675
None
1.23A 3ia4C-3vtaA:
undetectable
3ia4C-3vtaA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)
3vta CUCUMISIN
(Cucumis
melo)
5 / 12 ALA A 569
GLU A 570
SER A 729
ILE A 703
LEU A 675
None
1.22A 3ia4D-3vtaA:
undetectable
3ia4D-3vtaA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)
3vta CUCUMISIN
(Cucumis
melo)
4 / 4 PRO A 580
TYR A 537
GLY A 533
THR A 532
None
1.34A 3ib0A-3vtaA:
undetectable
3ib0A-3vtaA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)
3vta CUCUMISIN
(Cucumis
melo)
3 / 3 ARG A 628
ASP A 486
ASP A 631
None
0.92A 3jb3A-3vtaA:
undetectable
3jb3A-3vtaA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3vta CUCUMISIN
(Cucumis
melo)
5 / 12 GLY A 137
ALA A 262
ILE A 269
VAL A 138
GLU A 167
None
1.09A 3nvkI-3vtaA:
undetectable
3nvkI-3vtaA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)
3vta CUCUMISIN
(Cucumis
melo)
5 / 6 SER A 527
SER A 304
VAL A 325
GLY A 523
GLY A 496
None
DFP  A 801 (-3.4A)
None
DFP  A 801 (-3.1A)
None
1.43A 3rxfA-3vtaA:
undetectable
3rxfA-3vtaA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)
3vta CUCUMISIN
(Cucumis
melo)
4 / 5 THR A 444
ILE A 340
PHE A 346
LEU A 417
None
1.39A 3tf1A-3vtaA:
undetectable
3tf1A-3vtaA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1012_1
(HEMOLYTIC LECTIN
CEL-III)
3vta CUCUMISIN
(Cucumis
melo)
4 / 4 ASP A 254
GLY A 187
TRP A 246
ASP A 248
None
1.50A 3w9tA-3vtaA:
0.0
3w9tA-3vtaA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE501_1
(HEMOLYTIC LECTIN
CEL-III)
3vta CUCUMISIN
(Cucumis
melo)
4 / 4 ASP A 254
GLY A 187
TRP A 246
ASP A 248
None
1.49A 3w9tE-3vtaA:
0.0
3w9tE-3vtaA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3vta CUCUMISIN
(Cucumis
melo)
4 / 7 GLY A 137
VAL A 136
ILE A 178
PHE A 172
None
0.85A 4fglC-3vtaA:
2.5
4fglC-3vtaA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_2
(PROBABLE SUGAR
KINASE PROTEIN)
3vta CUCUMISIN
(Cucumis
melo)
4 / 4 SER A 291
ILE A 269
TYR A 259
PRO A 547
None
1.45A 4jkuB-3vtaA:
3.9
4jkuB-3vtaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_2
(SUGAR KINASE)
3vta CUCUMISIN
(Cucumis
melo)
4 / 4 SER A 291
ILE A 269
TYR A 259
PRO A 547
None
1.43A 4k8pA-3vtaA:
4.0
4k8pA-3vtaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_2
(SUGAR KINASE)
3vta CUCUMISIN
(Cucumis
melo)
4 / 4 SER A 291
ILE A 269
TYR A 259
PRO A 547
None
1.40A 4k8tA-3vtaA:
4.1
4k8tA-3vtaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_2
(SUGAR KINASE)
3vta CUCUMISIN
(Cucumis
melo)
4 / 4 SER A 291
ILE A 269
TYR A 259
PRO A 547
None
1.42A 4k93A-3vtaA:
2.1
4k93A-3vtaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_2
(SUGAR KINASE)
3vta CUCUMISIN
(Cucumis
melo)
4 / 4 SER A 291
ILE A 269
TYR A 259
PRO A 547
None
1.42A 4k93B-3vtaA:
3.9
4k93B-3vtaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_2
(SUGAR KINASE)
3vta CUCUMISIN
(Cucumis
melo)
4 / 4 SER A 291
ILE A 269
TYR A 259
PRO A 547
None
1.42A 4k9cA-3vtaA:
4.2
4k9cA-3vtaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_2
(SUGAR KINASE)
3vta CUCUMISIN
(Cucumis
melo)
4 / 4 SER A 291
ILE A 269
TYR A 259
PRO A 547
None
1.43A 4k9cB-3vtaA:
4.1
4k9cB-3vtaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)
3vta CUCUMISIN
(Cucumis
melo)
4 / 4 SER A 291
ILE A 269
TYR A 259
PRO A 547
None
1.44A 4kadA-3vtaA:
2.0
4kadA-3vtaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)
3vta CUCUMISIN
(Cucumis
melo)
4 / 4 SER A 291
ILE A 269
TYR A 259
PRO A 547
None
1.40A 4lc4B-3vtaA:
3.9
4lc4B-3vtaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)
3vta CUCUMISIN
(Cucumis
melo)
3 / 3 ASP A 427
VAL A 335
ASN A 519
None
0.81A 4lmnA-3vtaA:
undetectable
4lmnA-3vtaA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)
3vta CUCUMISIN
(Cucumis
melo)
3 / 3 TYR A 429
GLY A 402
PRO A 403
None
0.73A 4qwpA-3vtaA:
undetectable
4qwpA-3vtaA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)
3vta CUCUMISIN
(Cucumis
melo)
4 / 5 SER A 363
GLY A 364
ARG A 365
GLU A 398
None
1.18A 4r82A-3vtaA:
undetectable
4r82B-3vtaA:
undetectable
4r82A-3vtaA:
17.78
4r82B-3vtaA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)
3vta CUCUMISIN
(Cucumis
melo)
5 / 12 GLY A 164
GLY A 266
ASP A 268
ILE A 134
PRO A 159
None
1.25A 4rtsA-3vtaA:
undetectable
4rtsA-3vtaA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3vta CUCUMISIN
(Cucumis
melo)
4 / 4 GLY A 674
VAL A 708
PHE A 637
ILE A 725
None
1.07A 4xv2B-3vtaA:
undetectable
4xv2B-3vtaA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)
3vta CUCUMISIN
(Cucumis
melo)
5 / 12 GLY A 510
ASN A 519
PHE A 518
TYR A 223
LEU A 222
None
1.27A 5czyA-3vtaA:
undetectable
5czyA-3vtaA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)
3vta CUCUMISIN
(Cucumis
melo)
3 / 3 ASN A 247
ASP A 200
GLY A 142
None
0.53A 5fctB-3vtaA:
undetectable
5fctB-3vtaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)
3vta CUCUMISIN
(Cucumis
melo)
3 / 3 PRO A 490
ILE A 550
SER A 477
None
0.80A 5fsaA-3vtaA:
undetectable
5fsaA-3vtaA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
3vta CUCUMISIN
(Cucumis
melo)
3 / 3 THR A 524
SER A 304
ASP A 140
DFP  A 801 (-4.6A)
DFP  A 801 (-3.4A)
None
0.68A 5kvaA-3vtaA:
2.0
5kvaA-3vtaA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
3vta CUCUMISIN
(Cucumis
melo)
3 / 3 THR A 524
SER A 304
ASP A 140
DFP  A 801 (-4.6A)
DFP  A 801 (-3.4A)
None
0.68A 5kvaB-3vtaA:
2.0
5kvaB-3vtaA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)
3vta CUCUMISIN
(Cucumis
melo)
5 / 12 ILE A 269
GLY A 137
SER A 271
ALA A 535
VAL A 234
None
1.09A 5n0oA-3vtaA:
undetectable
5n0oA-3vtaA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)
3vta CUCUMISIN
(Cucumis
melo)
5 / 12 ILE A 269
GLY A 137
SER A 271
ALA A 535
VAL A 234
None
1.09A 5n0oB-3vtaA:
undetectable
5n0oB-3vtaA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)
3vta CUCUMISIN
(Cucumis
melo)
4 / 8 TRP A 246
THR A 141
THR A 201
ARG A 199
None
1.39A 5tzoA-3vtaA:
undetectable
5tzoA-3vtaA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)
3vta CUCUMISIN
(Cucumis
melo)
4 / 8 TRP A 246
THR A 141
THR A 201
ARG A 199
None
1.41A 5tzoC-3vtaA:
undetectable
5tzoC-3vtaA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)
3vta CUCUMISIN
(Cucumis
melo)
4 / 8 PRO A 543
THR A 536
TRP A 162
PRO A 159
None
1.03A 5x2sI-3vtaA:
undetectable
5x2sJ-3vtaA:
undetectable
5x2sK-3vtaA:
undetectable
5x2sI-3vtaA:
15.07
5x2sJ-3vtaA:
13.19
5x2sK-3vtaA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)
3vta CUCUMISIN
(Cucumis
melo)
5 / 12 ARG A 332
GLY A 226
THR A 211
GLY A 232
GLY A 214
None
1.21A 6brdB-3vtaA:
undetectable
6brdB-3vtaA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)
3vta CUCUMISIN
(Cucumis
melo)
4 / 5 THR A 112
ARG A 332
THR A 208
ASP A 200
None
1.48A 6ectA-3vtaA:
undetectable
6ectA-3vtaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)
3vta CUCUMISIN
(Cucumis
melo)
4 / 5 THR A 112
ARG A 332
THR A 208
ASP A 200
None
1.42A 6ecxA-3vtaA:
undetectable
6ecxA-3vtaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)
3vta CUCUMISIN
(Cucumis
melo)
5 / 12 PRO A 490
GLY A 306
THR A 314
THR A 315
ILE A 492
None
DFP  A 801 ( 4.5A)
None
None
None
0.90A 6emuC-3vtaA:
2.2
6emuC-3vtaA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)
3vta CUCUMISIN
(Cucumis
melo)
5 / 11 HIS A 577
GLY A 496
SER A 328
PHE A 117
ALA A 469
None
1.11A 6ieyA-3vtaA:
3.9
6ieyB-3vtaA:
2.5
6ieyA-3vtaA:
19.29
6ieyB-3vtaA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)
3vta CUCUMISIN
(Cucumis
melo)
5 / 11 HIS A 577
HIS A 530
SER A 328
PHE A 117
ALA A 469
None
1.32A 6ieyA-3vtaA:
3.9
6ieyB-3vtaA:
2.5
6ieyA-3vtaA:
19.29
6ieyB-3vtaA:
19.29