SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vtf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 9 GLY A 129
GLY A 175
SER A 152
GLU A 205
GLY A 177
 None
 1.19A 1jhoA-3vtfA:
2.9		 1jhoA-3vtfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 9 GLY A 129
GLY A 175
SER A 152
GLU A 205
GLY A 177
 None
 1.19A 1jhrA-3vtfA:
undetectable		 1jhrA-3vtfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 9 GLY A 129
GLY A 175
SER A 152
GLU A 205
GLY A 177
 None
 1.20A 1jhyA-3vtfA:
3.0		 1jhyA-3vtfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 9 GLY A 129
GLY A 175
SER A 152
GLU A 205
GLY A 177
 None
 1.17A 1l4nA-3vtfA:
undetectable		 1l4nA-3vtfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 9 GLY A 129
GLY A 175
SER A 152
GLU A 205
GLY A 177
 None
 1.18A 1l5kA-3vtfA:
undetectable		 1l5kA-3vtfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 9 GLY A 129
GLY A 175
SER A 152
GLU A 205
GLY A 177
 None
 1.17A 1l5lA-3vtfA:
3.0		 1l5lA-3vtfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 9 GLY A 129
GLY A 175
SER A 152
GLU A 205
GLY A 177
 None
 1.16A 1l5mA-3vtfA:
undetectable		 1l5mA-3vtfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 12 ILE A 385
ALA A 387
ARG A 334
GLN A 302
ARG A 345
 None
 1.47A 1u70A-3vtfA:
2.1		 1u70A-3vtfA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 8 LEU A 134
ARG A  98
VAL A  85
GLY A  86
 None
 0.91A 2qd5B-3vtfA:
2.8		 2qd5B-3vtfA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 12 VAL A 363
SER A 333
THR A 388
VAL A 318
ALA A 339
 None
 1.23A 2x2iC-3vtfA:
undetectable		 2x2iC-3vtfA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 12 LEU A  23
HIS A  25
ASN A 153
LEU A   4
PHE A 166
 None
 1.10A 3g1uA-3vtfA:
undetectable		 3g1uA-3vtfA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 6 GLN A 302
LEU A 304
GLU A 305
LEU A 311
 None
 0.85A 3h5gA-3vtfA:
undetectable
3h5gC-3vtfA:
undetectable		 3h5gA-3vtfA:
6.27
3h5gC-3vtfA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 10 TYR A 237
GLY A 255
VAL A 234
ASN A 223
GLY A 226
 None
UPG  A1001 (-3.2A)
None
None
None
 1.31A 3km6A-3vtfA:
undetectable		 3km6A-3vtfA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 9 TYR A 237
GLY A 255
VAL A 234
ASN A 223
GLY A 226
 None
UPG  A1001 (-3.2A)
None
None
None
 1.33A 3kmoA-3vtfA:
undetectable		 3kmoA-3vtfA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 7 LEU A 119
ASP A 178
ARG A 180
ALA A 181
 None
 1.19A 3mbgA-3vtfA:
undetectable
3mbgB-3vtfA:
undetectable		 3mbgA-3vtfA:
13.96
3mbgB-3vtfA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 11 VAL A  14
ALA A  17
GLY A  43
ILE A  47
LEU A  65
 None
 1.08A 3zosA-3vtfA:
undetectable
3zosB-3vtfA:
undetectable		 3zosA-3vtfA:
23.27
3zosB-3vtfA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 6 GLY A  29
ALA A  68
TYR A  30
GLU A  72
 None
 0.94A 4ae1A-3vtfA:
undetectable		 4ae1A-3vtfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 6 TYR A 393
GLN A 392
ASP A 373
GLN A 375
 None
 1.19A 4azvA-3vtfA:
5.0		 4azvA-3vtfA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 9 VAL A 121
VAL A 122
GLU A 155
GLY A 175
ALA A 181
 None
None
UPG  A1001 (-3.7A)
None
None
 1.14A 4fwdA-3vtfA:
undetectable		 4fwdA-3vtfA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 5 PRO A 154
ASN A 153
ILE A 172
VAL A 188
 None
 1.41A 4hytA-3vtfA:
4.2		 4hytA-3vtfA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 6 SER A 367
GLY A 320
ASP A 353
GLY A 335
 None
 1.01A 4koeA-3vtfA:
undetectable
4koeB-3vtfA:
undetectable
4koeC-3vtfA:
undetectable		 4koeA-3vtfA:
20.15
4koeB-3vtfA:
20.15
4koeC-3vtfA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 9 GLY A 129
GLY A 175
SER A 152
GLU A 205
GLY A 177
 None
 1.17A 4kqiA-3vtfA:
undetectable		 4kqiA-3vtfA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 6 ASP A 268
ALA A 271
THR A 125
THR A  87
 None
 1.45A 4w5rA-3vtfA:
undetectable		 4w5rA-3vtfA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 6 GLY A 320
ASP A 353
GLY A 335
SER A 367
 None
 1.02A 4z53A-3vtfA:
2.1
4z53B-3vtfA:
undetectable		 4z53A-3vtfA:
21.53
4z53B-3vtfA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 6 SER A 367
GLY A 320
ASP A 353
GLY A 335
 None
 0.83A 5cdnA-3vtfA:
undetectable
5cdnB-3vtfA:
undetectable		 5cdnA-3vtfA:
22.67
5cdnB-3vtfA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 6 SER A 367
GLY A 320
ASP A 353
GLY A 335
 None
 0.81A 5cdnR-3vtfA:
undetectable
5cdnS-3vtfA:
undetectable		 5cdnR-3vtfA:
22.67
5cdnS-3vtfA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 12 ILE A 172
TYR A 189
GLY A 175
LEU A 119
HIS A 118
 None
 1.38A 5esgA-3vtfA:
undetectable		 5esgA-3vtfA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_A_NIZA809_1
(CATALASE-PEROXIDASE)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 9 GLU A 337
VAL A 363
GLY A 335
SER A 333
LEU A 321
 None
 1.49A 5ksnA-3vtfA:
undetectable		 5ksnA-3vtfA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_2
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 4 ASP A 353
PRO A 391
GLU A 394
TYR A 398
 None
 1.37A 5xprA-3vtfA:
1.6		 5xprA-3vtfA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 3vtf UDP-GLUCOSE
6-DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 4 ARG A 137
GLU A 141
GLU A 101
ARG A 105
 None
 1.18A 6fk2A-3vtfA:
undetectable		 6fk2A-3vtfA:
13.01