SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vth'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		3 / 3 LEU A 710
SER A 700
ASN A 733
 None
None
AP2  A 806 (-4.9A)
 0.50A 1bx4A-3vthA:
undetectable		 1bx4A-3vthA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 9 GLY A 407
GLY A 735
GLY A 701
GLY A 702
ASP A 507
 None
None
AP2  A 806 ( 4.3A)
AP2  A 806 (-3.3A)
FE  A 807 ( 3.1A)
 0.94A 1mxdA-3vthA:
undetectable		 1mxdA-3vthA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 11 GLY A 407
GLY A 735
GLY A 701
GLY A 702
ASP A 507
 None
None
AP2  A 806 ( 4.3A)
AP2  A 806 (-3.3A)
FE  A 807 ( 3.1A)
 0.97A 1mxgA-3vthA:
1.9		 1mxgA-3vthA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 6 ARG A 383
ALA A 388
ILE A  19
PRO A 109
 GOL  A 812 (-2.7A)
None
None
None
 1.20A 1oniH-3vthA:
undetectable
1oniI-3vthA:
undetectable		 1oniH-3vthA:
11.53
1oniI-3vthA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		3 / 3 CYH A 186
ARG A 128
CYH A 167
 ZN  A 802 (-2.3A)
None
ZN  A 802 (-2.3A)
 1.50A 1p9gA-3vthA:
undetectable		 1p9gA-3vthA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 5 ILE A 205
ARG A 130
LEU A 193
PRO A 132
 None
 1.43A 1s8fA-3vthA:
undetectable
1s8fB-3vthA:
undetectable		 1s8fA-3vthA:
12.92
1s8fB-3vthA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 11 SER A 670
ILE A 559
ALA A 606
ILE A 551
PHE A 600
 None
 1.25A 1uduA-3vthA:
undetectable		 1uduA-3vthA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A 684
ILE A 688
LEU A 699
VAL A 697
LEU A 717
 None
 1.32A 2bxfB-3vthA:
undetectable		 2bxfB-3vthA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 9 LEU A 651
LEU A 653
ILE A 652
PHE A 600
LEU A 536
 None
 1.17A 2f78A-3vthA:
undetectable		 2f78A-3vthA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 9 LEU A 651
LEU A 653
ILE A 652
PHE A 600
LEU A 536
 None
 1.18A 2f78B-3vthA:
undetectable		 2f78B-3vthA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 9 LEU A 651
LEU A 653
ILE A 652
PHE A 600
LEU A 536
 None
 1.25A 2f7aA-3vthA:
undetectable		 2f7aA-3vthA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A 348
ALA A 352
ILE A 217
HIS A 314
ILE A 313
 None
 1.18A 2jn3A-3vthA:
undetectable		 2jn3A-3vthA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 6 VAL A 517
ASP A 460
HIS A 483
TYR A 409
 None
None
FE  A 807 ( 3.4A)
AP2  A 806 (-4.2A)
 1.23A 2zs9A-3vthA:
undetectable		 2zs9A-3vthA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 8 ILE A 737
HIS A 487
TYR A 465
GLY A 510
 None
FE  A 807 ( 3.4A)
None
AP2  A 806 ( 4.8A)
 0.93A 3b9lA-3vthA:
undetectable		 3b9lA-3vthA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 5 ILE A 737
HIS A 487
TYR A 465
GLY A 510
 None
FE  A 807 ( 3.4A)
None
AP2  A 806 ( 4.8A)
 1.05A 3b9mA-3vthA:
undetectable		 3b9mA-3vthA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 11 ALA A 237
ILE A 217
ILE A 220
LEU A 317
ILE A 325
 None
 0.98A 3clbA-3vthA:
undetectable		 3clbA-3vthA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 12 ALA A 237
ILE A 217
ILE A 220
LEU A 317
ILE A 325
 None
 1.02A 3clbC-3vthA:
undetectable		 3clbC-3vthA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 10 ALA A 237
ILE A 217
ILE A 220
LEU A 317
ILE A 325
 None
 0.98A 3hbbA-3vthA:
undetectable		 3hbbA-3vthA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 11 ALA A 237
ILE A 217
ILE A 220
LEU A 317
ILE A 325
 None
 1.04A 3hbbC-3vthA:
undetectable		 3hbbC-3vthA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 8 ILE A  19
PRO A 106
GLY A  18
PRO A 391
 None
 0.77A 3lslA-3vthA:
undetectable
3lslD-3vthA:
undetectable		 3lslA-3vthA:
19.58
3lslD-3vthA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 8 PRO A 391
ILE A  19
PRO A 106
GLY A  18
 None
 0.75A 3lslA-3vthA:
undetectable
3lslD-3vthA:
undetectable		 3lslA-3vthA:
19.58
3lslD-3vthA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		3 / 3 HIS A 487
HIS A 484
HIS A 483
 FE  A 807 ( 3.4A)
None
FE  A 807 ( 3.4A)
 0.77A 3mihA-3vthA:
undetectable		 3mihA-3vthA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		6 / 11 TYR A 511
GLY A 510
ASP A 460
GLY A 701
ALA A 486
ALA A 489
 None
AP2  A 806 ( 4.8A)
None
AP2  A 806 ( 4.3A)
None
None
 1.41A 3sufC-3vthA:
undetectable		 3sufC-3vthA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 11 GLY A 598
ASP A 507
GLY A 508
VAL A 594
HIS A 484
 AP2  A 806 (-3.2A)
FE  A 807 ( 3.1A)
AP2  A 806 (-3.0A)
None
None
 1.37A 4c5lA-3vthA:
3.0		 4c5lA-3vthA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 10 GLY A 598
ASP A 507
GLY A 508
VAL A 594
HIS A 484
 AP2  A 806 (-3.2A)
FE  A 807 ( 3.1A)
AP2  A 806 (-3.0A)
None
None
 1.40A 4c5lD-3vthA:
undetectable		 4c5lD-3vthA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 10 GLY A 598
ASP A 507
GLY A 508
VAL A 594
HIS A 484
 AP2  A 806 (-3.2A)
FE  A 807 ( 3.1A)
AP2  A 806 (-3.0A)
None
None
 1.29A 4c5nD-3vthA:
undetectable		 4c5nD-3vthA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 12 ASP A 514
THR A 513
SER A 700
SER A 595
TYR A 538
 None
 1.41A 4kn2A-3vthA:
undetectable		 4kn2A-3vthA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_1
(FOLATE RECEPTOR BETA)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 12 ASP A 514
THR A 513
SER A 700
SER A 595
TYR A 538
 None
 1.40A 4kn2C-3vthA:
undetectable		 4kn2C-3vthA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 12 LEU A 474
GLY A 407
GLY A 406
ALA A 471
GLY A 740
 None
 1.01A 4n09B-3vthA:
undetectable		 4n09B-3vthA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 12 VAL A 604
LEU A 709
PHE A 704
PHE A 601
GLY A 598
 None
None
None
AP2  A 806 (-3.7A)
AP2  A 806 (-3.2A)
 1.33A 4pevC-3vthA:
undetectable		 4pevC-3vthA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 12 ILE A 283
GLY A 305
PRO A 251
ALA A 298
ILE A 381
 None
APC  A 804 (-4.0A)
APC  A 804 (-4.0A)
APC  A 804 ( 4.5A)
None
 1.08A 4rvdA-3vthA:
undetectable		 4rvdA-3vthA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 6 TYR A 708
ASN A 706
LEU A 624
PHE A 673
 None
AP2  A 806 (-3.7A)
None
None
 0.92A 4twdB-3vthA:
undetectable
4twdC-3vthA:
undetectable		 4twdB-3vthA:
17.11
4twdC-3vthA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 6 TYR A 708
ASN A 706
LEU A 624
PHE A 673
 None
AP2  A 806 (-3.7A)
None
None
 0.96A 4twdD-3vthA:
undetectable
4twdE-3vthA:
undetectable		 4twdD-3vthA:
17.11
4twdE-3vthA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 6 TYR A 708
ASN A 706
LEU A 624
PHE A 673
 None
AP2  A 806 (-3.7A)
None
None
 0.85A 4twdI-3vthA:
undetectable
4twdJ-3vthA:
undetectable		 4twdI-3vthA:
17.11
4twdJ-3vthA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 6 LEU A 607
LEU A 624
ILE A 652
PHE A 673
 None
 1.05A 4y4dA-3vthA:
undetectable		 4y4dA-3vthA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 6 ILE A  14
ARG A  12
ILE A  60
GLU A  61
 None
 1.27A 4zzcA-3vthA:
undetectable
4zzcB-3vthA:
undetectable		 4zzcA-3vthA:
20.30
4zzcB-3vthA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 6 ILE A  14
ARG A  12
ILE A  60
GLU A  61
 None
 1.25A 4zzcB-3vthA:
undetectable
4zzcC-3vthA:
undetectable		 4zzcB-3vthA:
20.30
4zzcC-3vthA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 4 VAL A  29
ILE A  16
ASN A  44
VAL A  23
 None
None
PO4  A 803 (-3.4A)
PO4  A 803 (-4.1A)
 1.07A 5ajqA-3vthA:
undetectable		 5ajqA-3vthA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 12 GLY A 736
ASN A 411
GLY A 701
SER A 700
GLY A 406
 None
None
AP2  A 806 ( 4.3A)
None
None
 1.26A 5hikA-3vthA:
undetectable		 5hikA-3vthA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 4 GLU A 650
PRO A 649
ILE A 652
LEU A 651
 None
 1.05A 5m45A-3vthA:
undetectable		 5m45A-3vthA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 4 GLU A 650
PRO A 649
ILE A 652
LEU A 651
 None
 1.00A 5m45D-3vthA:
undetectable		 5m45D-3vthA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 4 GLU A 650
PRO A 649
ILE A 652
LEU A 651
 None
 1.03A 5m45G-3vthA:
undetectable		 5m45G-3vthA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 4 GLU A 650
PRO A 649
ILE A 652
LEU A 651
 None
 1.01A 5m45J-3vthA:
undetectable		 5m45J-3vthA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 12 SER A 596
VAL A 517
GLY A 510
GLY A 508
TYR A 409
 None
None
AP2  A 806 ( 4.8A)
AP2  A 806 (-3.0A)
AP2  A 806 (-4.2A)
 1.15A 5nnaA-3vthA:
undetectable		 5nnaA-3vthA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 12 SER A 596
VAL A 517
GLY A 510
GLY A 508
TYR A 409
 None
None
AP2  A 806 ( 4.8A)
AP2  A 806 (-3.0A)
AP2  A 806 (-4.2A)
 1.13A 5nnaB-3vthA:
undetectable		 5nnaB-3vthA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 12 SER A 596
VAL A 517
GLY A 510
GLY A 508
TYR A 409
 None
None
AP2  A 806 ( 4.8A)
AP2  A 806 (-3.0A)
AP2  A 806 (-4.2A)
 1.12A 5nnaC-3vthA:
undetectable		 5nnaC-3vthA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 12 SER A 596
VAL A 517
GLY A 510
GLY A 508
TYR A 409
 None
None
AP2  A 806 ( 4.8A)
AP2  A 806 (-3.0A)
AP2  A 806 (-4.2A)
 1.17A 5nnaD-3vthA:
undetectable		 5nnaD-3vthA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 5 LEU A 286
LYS A 263
LEU A 276
GLU A 273
 None
 1.33A 5weaA-3vthA:
2.8		 5weaA-3vthA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 8 ILE A 504
ARG A 379
GLU A 494
SER A 490
 None
 1.15A 6c06C-3vthA:
undetectable		 6c06C-3vthA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 9 VAL A 594
LEU A 556
ARG A 599
ALA A 555
ASP A 602
 None
None
AP2  A 806 (-4.1A)
None
None
 1.20A 6c2mB-3vthA:
undetectable		 6c2mB-3vthA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 6 VAL A 594
PRO A 649
ALA A 592
THR A 591
 None
 1.01A 6cduB-3vthA:
undetectable
6cduC-3vthA:
undetectable		 6cduB-3vthA:
17.30
6cduC-3vthA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 7 VAL A 594
PRO A 649
ALA A 592
THR A 591
 None
 0.98A 6cduC-3vthA:
undetectable
6cduD-3vthA:
undetectable		 6cduC-3vthA:
17.30
6cduD-3vthA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		4 / 7 ALA A 592
THR A 591
VAL A 594
PRO A 649
 None
 0.95A 6cduF-3vthA:
1.9
6cduJ-3vthA:
undetectable		 6cduF-3vthA:
17.30
6cduJ-3vthA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		3 / 3 GLU A 273
LEU A 276
ARG A 281
 None
 0.53A 6d8fA-3vthA:
3.0		 6d8fA-3vthA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 3vth HYDROGENASE
MATURATION FACTOR
(Caldanaerobacter
subterraneus) 		5 / 9 ILE A  64
ILE A  67
GLU A  84
VAL A  82
ILE A  80
 None
 1.42A 6hloA-3vthA:
undetectable		 6hloA-3vthA:
21.39