SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vtz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCB_P_DHIP3_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-L-GLN-D-PHE
-L-HIS-D-PRO-OH)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 5 TYR A  86
TYR A 145
GLU A  84
GLN A 134
 None
 1.38A 1mcbA-3vtzA:
0.0
1mcbB-3vtzA:
0.0
1mcbP-3vtzA:
undetectable		 1mcbA-3vtzA:
21.28
1mcbB-3vtzA:
21.28
1mcbP-3vtzA:
1.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		6 / 11 GLY A  13
LEU A  38
ASP A  53
VAL A  54
ALA A  81
VAL A 103
 None
 0.39A 1uayA-3vtzA:
29.5		 1uayA-3vtzA:
30.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		7 / 10 GLY A  13
SER A  15
LEU A  38
ASP A  53
VAL A  54
ALA A  81
VAL A 103
 None
 1.16A 1uayB-3vtzA:
29.8		 1uayB-3vtzA:
30.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		7 / 10 GLY A  13
SER A  16
LEU A  38
ASP A  53
VAL A  54
ALA A  81
VAL A 103
 None
 0.72A 1uayB-3vtzA:
29.8		 1uayB-3vtzA:
30.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 5 LEU A  77
ASN A  79
VAL A 159
ALA A 112
 None
 1.05A 2cizA-3vtzA:
undetectable		 2cizA-3vtzA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		5 / 12 GLY A 125
ILE A  74
ALA A 164
VAL A 118
LEU A 120
 None
 0.97A 2yqzA-3vtzA:
5.2		 2yqzA-3vtzA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		5 / 10 ASP A  39
GLY A  14
GLY A  13
VAL A  60
ILE A  52
 None
 1.04A 3em4V-3vtzA:
undetectable		 3em4V-3vtzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 6 TYR A 145
ILE A 100
SER A 135
SER A 132
 None
 1.34A 3pmzD-3vtzA:
undetectable		 3pmzD-3vtzA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 5 ASP A  53
GLY A 107
VAL A 103
THR A  12
 None
 1.11A 3vqrB-3vtzA:
5.7		 3vqrB-3vtzA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 7 TYR A 109
VAL A 105
ILE A 101
ASN A 106
 None
 0.87A 4a97E-3vtzA:
undetectable		 4a97E-3vtzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 8 TYR A 109
VAL A 105
ILE A 101
ASN A 106
 None
 0.86A 4a97C-3vtzA:
undetectable		 4a97C-3vtzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 8 TYR A 109
VAL A 105
ILE A 101
ASN A 106
 None
 0.91A 4a97D-3vtzA:
undetectable		 4a97D-3vtzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 8 TYR A 109
VAL A 105
ILE A 101
ASN A 106
 None
 0.87A 4a97G-3vtzA:
undetectable		 4a97G-3vtzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 7 TYR A 109
VAL A 105
ILE A 101
ASN A 106
 None
 0.93A 4a97H-3vtzA:
undetectable		 4a97H-3vtzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 8 TYR A 109
VAL A 105
ILE A 101
ASN A 106
 None
 0.91A 4a97I-3vtzA:
undetectable		 4a97I-3vtzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		5 / 9 ALA A 227
ILE A 122
VAL A 118
ALA A   9
ILE A 128
 None
 0.98A 4r21B-3vtzA:
undetectable		 4r21B-3vtzA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		5 / 12 GLY A  14
ASP A  53
VAL A  54
THR A  55
VAL A  78
 None
 1.06A 5kocA-3vtzA:
4.5		 5kocA-3vtzA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 3vtz GLUCOSE
1-DEHYDROGENASE
(Thermoplasma
volcanium) 		4 / 7 ASN A 195
ALA A 196
LYS A 200
GLU A 203
 None
 0.99A 6ci6A-3vtzA:
undetectable		 6ci6A-3vtzA:
16.24