SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vu4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3vu4 KMHSV2
(Kluyveromyces
marxianus) 		4 / 8 SER A 289
VAL A 261
LEU A 259
VAL A 316
 None
 1.02A 1fduB-3vu4A:
undetectable		 1fduB-3vu4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3vu4 KMHSV2
(Kluyveromyces
marxianus) 		3 / 3 SER A 117
ASP A 114
ASP A  95
 None
 0.80A 2plwA-3vu4A:
undetectable		 2plwA-3vu4A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3vu4 KMHSV2
(Kluyveromyces
marxianus) 		4 / 8 LEU A  29
VAL A  59
TYR A  20
LEU A 348
 None
 0.99A 3v81A-3vu4A:
undetectable		 3v81A-3vu4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3vu4 KMHSV2
(Kluyveromyces
marxianus) 		3 / 3 ASP A 240
LEU A 259
VAL A 297
 None
 0.70A 4jecB-3vu4A:
undetectable		 4jecB-3vu4A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3vu4 KMHSV2
(Kluyveromyces
marxianus) 		5 / 12 VAL A 196
LEU A 198
ILE A 193
ILE A 186
GLY A 223
 None
 0.98A 4y8wC-3vu4A:
undetectable		 4y8wC-3vu4A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3vu4 KMHSV2
(Kluyveromyces
marxianus) 		3 / 3 MET A 195
ASP A 240
ARG A  60
 None
 1.02A 5z6kA-3vu4A:
undetectable		 5z6kA-3vu4A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 3vu4 KMHSV2
(Kluyveromyces
marxianus) 		5 / 10 LEU A  62
SER A 111
HIS A  63
PHE A 102
CYH A  28
 None
None
SO4  A 408 ( 3.7A)
None
None
 1.43A 6gnfC-3vu4A:
undetectable		 6gnfC-3vu4A:
20.32