SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vuo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 3vuo NTNHA
(Clostridium
botulinum) 		4 / 7 PHE A  30
ALA A  42
PHE A 172
TRP A  40
 None
 1.08A 1lqtA-3vuoA:
undetectable		 1lqtA-3vuoA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 3vuo NTNHA
(Clostridium
botulinum) 		4 / 7 PHE A  30
ALA A  42
PHE A 172
TRP A  40
 None
 1.08A 1lquA-3vuoA:
undetectable		 1lquA-3vuoA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 3vuo NTNHA
(Clostridium
botulinum) 		3 / 3 PHE A 203
TYR A 368
PRO A 205
 None
 0.86A 1mcnA-3vuoA:
undetectable
1mcnB-3vuoA:
undetectable
1mcnP-3vuoA:
undetectable		 1mcnA-3vuoA:
10.03
1mcnB-3vuoA:
10.03
1mcnP-3vuoA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 3vuo NTNHA
(Clostridium
botulinum) 		4 / 7 PHE A 905
LEU A 954
VAL A 957
GLY A 937
 None
 0.82A 1p2yA-3vuoA:
undetectable		 1p2yA-3vuoA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3vuo NTNHA
(Clostridium
botulinum) 		3 / 3 ALA A 199
VAL A 170
TRP A  40
 None
 1.00A 1tkqA-3vuoA:
undetectable		 1tkqA-3vuoA:
0.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 3vuo NTNHA
(Clostridium
botulinum) 		4 / 8 TRP A 962
TYR A1032
GLU A1014
GLY A 871
 None
 0.80A 2ha4A-3vuoA:
undetectable		 2ha4A-3vuoA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 3vuo NTNHA
(Clostridium
botulinum) 		4 / 7 TRP A 962
TYR A1032
GLU A1014
GLY A 871
 None
 0.83A 2ha4B-3vuoA:
undetectable		 2ha4B-3vuoA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 3vuo NTNHA
(Clostridium
botulinum) 		4 / 6 LEU A1019
SER A 968
ASP A 970
GLU A1027
 None
 1.01A 2j2pE-3vuoA:
undetectable
2j2pF-3vuoA:
undetectable		 2j2pE-3vuoA:
10.79
2j2pF-3vuoA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3vuo NTNHA
(Clostridium
botulinum) 		3 / 3 LYS A 663
TYR A 281
PRO A 280
 None
 1.33A 2j9cC-3vuoA:
undetectable		 2j9cC-3vuoA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 3vuo NTNHA
(Clostridium
botulinum) 		3 / 3 PHE A 358
SER A 258
LEU A 248
 None
 0.37A 2w1bA-3vuoA:
undetectable		 2w1bA-3vuoA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3vuo NTNHA
(Clostridium
botulinum) 		4 / 6 ILE A   3
ARG A  88
THR A 223
LEU A 226
 None
 0.92A 3ag1N-3vuoA:
3.5
3ag1W-3vuoA:
undetectable		 3ag1N-3vuoA:
16.56
3ag1W-3vuoA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3vuo NTNHA
(Clostridium
botulinum) 		3 / 3 LEU A 516
TRP A 591
TYR A 533
 None
 0.99A 3aicA-3vuoA:
undetectable		 3aicA-3vuoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3vuo NTNHA
(Clostridium
botulinum) 		3 / 3 LEU A 516
TRP A 591
TYR A 533
 None
 0.97A 3aicB-3vuoA:
undetectable		 3aicB-3vuoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3vuo NTNHA
(Clostridium
botulinum) 		3 / 3 LEU A 516
TRP A 591
TYR A 533
 None
 1.00A 3aicE-3vuoA:
undetectable		 3aicE-3vuoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3vuo NTNHA
(Clostridium
botulinum) 		3 / 3 LEU A 516
TRP A 591
TYR A 533
 None
 0.99A 3aicG-3vuoA:
undetectable		 3aicG-3vuoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 3vuo NTNHA
(Clostridium
botulinum) 		3 / 3 LEU A 516
TRP A 591
TYR A 533
 None
 0.98A 3aicH-3vuoA:
undetectable		 3aicH-3vuoA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 3vuo NTNHA
(Clostridium
botulinum) 		4 / 6 LEU A 226
SER A 229
LEU A 233
LEU A  98
 None
 1.04A 3f33A-3vuoA:
3.0		 3f33A-3vuoA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3vuo NTNHA
(Clostridium
botulinum) 		5 / 12 PHE A 203
ILE A 171
ILE A 102
ILE A 227
VAL A  35
 None
 1.12A 3fpjB-3vuoA:
2.6		 3fpjB-3vuoA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 3vuo NTNHA
(Clostridium
botulinum) 		3 / 3 ASP A 272
PHE A 275
SER A 822
 None
 0.80A 3i5uB-3vuoA:
undetectable		 3i5uB-3vuoA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3vuo NTNHA
(Clostridium
botulinum) 		5 / 12 ILE A  83
PRO A  43
ALA A  42
ALA A  36
VAL A  35
 None
 0.95A 3jb2A-3vuoA:
undetectable		 3jb2A-3vuoA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3vuo NTNHA
(Clostridium
botulinum) 		5 / 12 ILE A  83
PRO A  43
ALA A  42
ALA A  36
VAL A  35
 None
 1.02A 3jb3A-3vuoA:
undetectable		 3jb3A-3vuoA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 3vuo NTNHA
(Clostridium
botulinum) 		3 / 3 VAL A 744
VAL A 588
TRP A 591
 None
 0.92A 3l8lC-3vuoA:
undetectable
3l8lD-3vuoA:
undetectable		 3l8lC-3vuoA:
1.30
3l8lD-3vuoA:
1.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3vuo NTNHA
(Clostridium
botulinum) 		5 / 11 ILE A 967
ALA A 986
PHE A 940
ILE A 993
VAL A 969
 None
 0.93A 3n0hA-3vuoA:
undetectable		 3n0hA-3vuoA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3vuo NTNHA
(Clostridium
botulinum) 		5 / 12 ILE A 967
ALA A 986
PHE A 940
ILE A 993
VAL A 969
 None
 0.90A 3s3vA-3vuoA:
undetectable		 3s3vA-3vuoA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 3vuo NTNHA
(Clostridium
botulinum) 		4 / 5 SER A1045
ARG A 908
TYR A1012
VAL A 872
 None
 1.28A 3sufC-3vuoA:
undetectable		 3sufC-3vuoA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 3vuo NTNHA
(Clostridium
botulinum) 		4 / 8 TYR A 660
TYR A 438
ILE A 634
ILE A 775
 None
 0.89A 4afgD-3vuoA:
undetectable
4afgE-3vuoA:
undetectable		 4afgD-3vuoA:
11.48
4afgE-3vuoA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3vuo NTNHA
(Clostridium
botulinum) 		4 / 7 ASP A 479
ASP A 190
ASN A 193
GLU A 192
 None
 1.18A 4fevB-3vuoA:
undetectable		 4fevB-3vuoA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3vuo NTNHA
(Clostridium
botulinum) 		4 / 8 TYR A 558
LEU A 562
VAL A 565
TYR A 569
 None
 0.67A 4fgzB-3vuoA:
undetectable		 4fgzB-3vuoA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3vuo NTNHA
(Clostridium
botulinum) 		5 / 6 LEU A 101
ILE A 102
LYS A 323
LEU A 230
TYR A 234
 None
 1.38A 4w5nA-3vuoA:
1.9		 4w5nA-3vuoA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 3vuo NTNHA
(Clostridium
botulinum) 		3 / 3 ALA A  32
TRP A  40
VAL A  41
 None
 0.26A 4w9nC-3vuoA:
undetectable		 4w9nC-3vuoA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3vuo NTNHA
(Clostridium
botulinum) 		5 / 12 GLY A 369
LEU A 222
ILE A 227
GLY A  95
THR A  92
 None
 1.10A 4ze2A-3vuoA:
0.6		 4ze2A-3vuoA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 3vuo NTNHA
(Clostridium
botulinum) 		4 / 5 TYR A 372
PHE A  78
LEU A  86
PRO A 205
 None
 1.47A 5csyB-3vuoA:
undetectable		 5csyB-3vuoA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 3vuo NTNHA
(Clostridium
botulinum) 		4 / 7 ILE A 618
ILE A 760
SER A 678
LEU A 624
 None
 0.67A 5fukA-3vuoA:
undetectable
5fukB-3vuoA:
undetectable		 5fukA-3vuoA:
12.09
5fukB-3vuoA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 3vuo NTNHA
(Clostridium
botulinum) 		5 / 11 TYR A 431
ASP A 670
PHE A 430
ILE A 436
ILE A 262
 None
 1.05A 5hw8A-3vuoA:
undetectable
5hw8D-3vuoA:
undetectable		 5hw8A-3vuoA:
8.68
5hw8D-3vuoA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 3vuo NTNHA
(Clostridium
botulinum) 		5 / 10 ILE A 573
TRP A 591
TYR A 569
LEU A 536
PHE A 535
 None
 1.08A 5hw8C-3vuoA:
undetectable
5hw8H-3vuoA:
undetectable		 5hw8C-3vuoA:
8.68
5hw8H-3vuoA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3vuo NTNHA
(Clostridium
botulinum) 		5 / 12 GLY A 270
PHE A 358
ALA A 354
ILE A 216
PHE A 214
 None
 1.24A 5ih0A-3vuoA:
undetectable		 5ih0A-3vuoA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_A_RIOA600_0
(BIFUNCTIONAL AAC/APH)		 3vuo NTNHA
(Clostridium
botulinum) 		5 / 11 ASP A1043
SER A1196
TYR A1055
VAL A1105
TYR A1104
 None
 1.32A 5iqdA-3vuoA:
1.2		 5iqdA-3vuoA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_B_RIOB600_0
(BIFUNCTIONAL AAC/APH)		 3vuo NTNHA
(Clostridium
botulinum) 		5 / 11 ASP A1043
SER A1196
TYR A1055
VAL A1105
TYR A1104
 None
 1.30A 5iqdB-3vuoA:
0.0		 5iqdB-3vuoA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3vuo NTNHA
(Clostridium
botulinum) 		4 / 6 ILE A  89
ALA A 219
LEU A 222
ILE A  82
 None
 0.83A 5mvmB-3vuoA:
4.1
5mvmC-3vuoA:
5.3		 5mvmB-3vuoA:
5.36
5mvmC-3vuoA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3vuo NTNHA
(Clostridium
botulinum) 		4 / 6 ILE A   3
ARG A  88
THR A 223
LEU A 226
 None
 1.03A 5zcoN-3vuoA:
3.9
5zcoW-3vuoA:
undetectable		 5zcoN-3vuoA:
16.56
5zcoW-3vuoA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3vuo NTNHA
(Clostridium
botulinum) 		3 / 3 ILE A 967
ASN A 895
CYH A 927
 None
 0.76A 6bp4A-3vuoA:
undetectable		 6bp4A-3vuoA:
12.84