SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vup'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 ALA A 319
PHE A 308
PHE A 294
LEU A  51
PHE A 107
 None
 1.08A 1dtlA-3vupA:
undetectable		 1dtlA-3vupA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 ILE A  63
ASP A  34
GLY A  33
PHE A  32
ALA A  72
 None
 1.34A 1hvyB-3vupA:
undetectable		 1hvyB-3vupA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		4 / 6 LYS A  49
LYS A  50
ASP A  53
ALA A  54
 None
 0.35A 1iwhA-3vupA:
undetectable		 1iwhA-3vupA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 10 ILE A  63
ASP A  34
GLY A  33
PHE A  32
ALA A  72
 None
 1.44A 1ju6C-3vupA:
undetectable		 1ju6C-3vupA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 ILE A 211
GLY A 156
VAL A 220
ASP A 257
GLY A 217
 None
 0.91A 1kiaB-3vupA:
undetectable		 1kiaB-3vupA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 ILE A 211
GLY A 156
VAL A 220
ASP A 257
GLY A 217
 None
 0.90A 1kiaC-3vupA:
undetectable		 1kiaC-3vupA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 GLY A 156
VAL A 220
ASP A 257
ALA A 153
GLY A 217
 None
 1.16A 1nbiA-3vupA:
undetectable		 1nbiA-3vupA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 ILE A 211
GLY A 155
VAL A 220
ASP A 257
GLY A 217
 None
 1.11A 1nbiA-3vupA:
undetectable		 1nbiA-3vupA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 ILE A 211
GLY A 156
VAL A 220
ASP A 257
GLY A 217
 None
 1.01A 1nbiA-3vupA:
undetectable		 1nbiA-3vupA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 ILE A 211
GLY A 156
VAL A 220
ASP A 257
GLY A 217
 None
 0.99A 1nbiB-3vupA:
undetectable		 1nbiB-3vupA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 GLY A 292
GLN A 260
PHE A 107
ILE A 335
PHE A 308
 None
 1.38A 1p93D-3vupA:
undetectable		 1p93D-3vupA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 10 GLY A 318
PHE A 308
VAL A 291
GLY A 292
VAL A 311
 None
 1.26A 1v3qE-3vupA:
undetectable		 1v3qE-3vupA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		4 / 6 ALA A 208
TYR A 136
ILE A 137
LEU A 159
 None
 0.87A 1xvaA-3vupA:
undetectable
1xvaB-3vupA:
undetectable		 1xvaA-3vupA:
21.58
1xvaB-3vupA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 GLY A 165
HIS A 239
LEU A 204
MET A 222
LEU A 183
 None
 1.26A 1zgyA-3vupA:
undetectable		 1zgyA-3vupA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		4 / 8 SER A 241
PHE A 256
ALA A 208
LEU A 159
 None
 1.16A 2bxkA-3vupA:
undetectable		 2bxkA-3vupA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		4 / 7 HIS A 262
ASP A 257
THR A 221
TYR A 259
 None
None
None
SO4  A 402 (-4.6A)
 1.50A 2eijN-3vupA:
undetectable
2eijP-3vupA:
undetectable		 2eijN-3vupA:
19.96
2eijP-3vupA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		4 / 7 HIS A 262
ASP A 257
THR A 221
TYR A 259
 None
None
None
SO4  A 402 (-4.6A)
 1.50A 2eilN-3vupA:
undetectable
2eilP-3vupA:
undetectable		 2eilN-3vupA:
19.96
2eilP-3vupA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 VAL A 106
ILE A  44
LEU A  23
PRO A  24
PHE A  48
 None
 0.92A 2qk8A-3vupA:
undetectable		 2qk8A-3vupA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		6 / 12 ASN A 161
GLU A 162
HIS A 262
TYR A 264
GLU A 293
TRP A 322
 TRS  A 401 (-2.7A)
TRS  A 401 (-3.0A)
None
TRS  A 401 ( 4.8A)
TRS  A 401 (-2.7A)
TRS  A 401 (-3.8A)
 0.77A 2v3dA-3vupA:
15.2		 2v3dA-3vupA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 11 ASN A 161
GLU A 162
TYR A 264
GLU A 293
TRP A 322
 TRS  A 401 (-2.7A)
TRS  A 401 (-3.0A)
TRS  A 401 ( 4.8A)
TRS  A 401 (-2.7A)
TRS  A 401 (-3.8A)
 0.85A 2v3dB-3vupA:
13.9		 2v3dB-3vupA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		4 / 8 TYR A 102
LYS A  49
LYS A  50
PHE A 308
 None
 1.46A 3bjwD-3vupA:
undetectable		 3bjwD-3vupA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 GLY A 156
HIS A  64
ILE A  63
LEU A 141
TYR A 136
 None
 1.36A 3cs8A-3vupA:
undetectable		 3cs8A-3vupA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 VAL A 148
LEU A  95
MET A  88
ILE A  63
THR A  70
 None
 1.36A 3frqA-3vupA:
undetectable		 3frqA-3vupA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		4 / 5 ASN A 112
ALA A 114
ALA A 113
LYS A 194
 None
TRS  A 401 ( 3.7A)
None
None
 1.34A 3kp2B-3vupA:
undetectable		 3kp2B-3vupA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 ASP A 158
GLY A 165
ILE A 127
TYR A 197
ILE A 200
 None
 1.07A 3pwwA-3vupA:
undetectable		 3pwwA-3vupA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		4 / 8 PHE A 294
HIS A 262
GLY A 292
ASN A 330
 None
None
None
SO4  A 404 (-3.9A)
 0.99A 3v3nB-3vupA:
undetectable		 3v3nB-3vupA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		4 / 8 PHE A 294
HIS A 262
GLY A 292
ASN A 330
 None
None
None
SO4  A 404 (-3.9A)
 0.99A 3v3nC-3vupA:
undetectable		 3v3nC-3vupA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		3 / 3 ASN A  22
TRP A 322
ASP A 158
 None
TRS  A 401 (-3.8A)
None
 1.29A 4a7tA-3vupA:
undetectable
4a7tF-3vupA:
undetectable		 4a7tA-3vupA:
16.76
4a7tF-3vupA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 ILE A  63
ASP A  34
GLY A  33
PHE A  32
ALA A  72
 None
 1.31A 4eb4A-3vupA:
undetectable		 4eb4A-3vupA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 GLY A 165
HIS A 239
LEU A 204
MET A 222
LEU A 183
 None
 1.39A 4emaA-3vupA:
undetectable		 4emaA-3vupA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 LEU A 126
PHE A 203
TYR A 195
GLN A  66
MET A 160
 None
 1.44A 4j7xA-3vupA:
undetectable		 4j7xA-3vupA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 LEU A 126
TYR A 195
GLN A  66
ALA A 113
MET A 160
 None
 1.42A 4j7xA-3vupA:
undetectable		 4j7xA-3vupA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		4 / 5 LYS A  50
LEU A  51
GLU A  47
LEU A 324
 None
 1.37A 4k4yA-3vupA:
undetectable		 4k4yA-3vupA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		4 / 4 LYS A  50
LEU A  51
GLU A  47
LEU A 324
 None
 1.36A 4k4yE-3vupA:
undetectable		 4k4yE-3vupA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 11 ASN A 238
ILE A 200
TYR A 178
LEU A 159
ALA A 248
 SO4  A 402 ( 4.8A)
None
None
None
None
 1.42A 4m83A-3vupA:
undetectable		 4m83A-3vupA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 11 THR A 221
ALA A 317
GLY A 156
GLY A 155
SER A  58
 None
 1.02A 4qvlK-3vupA:
undetectable
4qvlL-3vupA:
undetectable		 4qvlK-3vupA:
19.77
4qvlL-3vupA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 11 THR A 221
ALA A 317
GLY A 156
GLY A 155
SER A  58
 None
 1.02A 4qvlY-3vupA:
undetectable
4qvlZ-3vupA:
undetectable		 4qvlY-3vupA:
19.77
4qvlZ-3vupA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 10 THR A 221
ALA A 317
GLY A 156
GLY A 155
SER A  58
 None
 1.02A 4qvmY-3vupA:
undetectable
4qvmZ-3vupA:
undetectable		 4qvmY-3vupA:
19.83
4qvmZ-3vupA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 11 THR A 221
ALA A 317
GLY A 156
GLY A 155
SER A  58
 None
 1.02A 4qvwK-3vupA:
undetectable
4qvwL-3vupA:
undetectable		 4qvwK-3vupA:
19.55
4qvwL-3vupA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 11 THR A 221
ALA A 317
GLY A 156
GLY A 155
SER A  58
 None
 1.02A 4qvwY-3vupA:
undetectable
4qvwZ-3vupA:
undetectable		 4qvwY-3vupA:
19.55
4qvwZ-3vupA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 GLY A 165
HIS A 239
LEU A 204
MET A 222
LEU A 183
 None
 1.36A 4xldA-3vupA:
undetectable		 4xldA-3vupA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 7 ILE A 104
LYS A  49
LEU A  51
GLY A  55
GLY A  56
 None
 1.29A 5a06C-3vupA:
undetectable		 5a06C-3vupA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 7 ILE A 104
LYS A  49
LEU A  51
GLY A  55
GLY A  56
 None
 1.27A 5a06E-3vupA:
undetectable		 5a06E-3vupA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 7 ILE A 104
LYS A  49
LEU A  51
GLY A  55
GLY A  56
 None
 1.29A 5a06F-3vupA:
undetectable		 5a06F-3vupA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		4 / 5 TYR A 197
GLY A 165
TYR A 240
GLY A 223
 None
 1.03A 5ayfA-3vupA:
undetectable		 5ayfA-3vupA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 11 THR A 221
ALA A 317
GLY A 156
GLY A 155
SER A  58
 None
 1.02A 5bxnK-3vupA:
undetectable
5bxnL-3vupA:
undetectable		 5bxnK-3vupA:
19.77
5bxnL-3vupA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 11 THR A 221
ALA A 317
GLY A 156
GLY A 155
SER A  58
 None
 1.03A 5bxnY-3vupA:
undetectable
5bxnZ-3vupA:
undetectable		 5bxnY-3vupA:
19.77
5bxnZ-3vupA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		4 / 6 TYR A 264
GLY A 292
GLU A 293
ASP A 158
 TRS  A 401 ( 4.8A)
None
TRS  A 401 (-2.7A)
None
 1.31A 5emlA-3vupA:
3.7		 5emlA-3vupA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		6 / 12 GLY A  56
ILE A 349
ASN A 103
VAL A  16
LEU A  18
LEU A   2
 None
 1.37A 5wy0A-3vupA:
undetectable		 5wy0A-3vupA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 3vup BETA-1,4-MANNANASE
(Aplysia
kurodai) 		5 / 12 GLY A 328
ILE A 338
GLY A  20
SER A 321
PHE A 294
 None
 1.02A 6c2mA-3vupA:
undetectable		 6c2mA-3vupA:
11.37