SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		5 / 10 ASP A  85
GLY A  82
VAL A  84
ARG A 207
TYR A 211
 None
 1.48A 1fohA-3vvaA:
undetectable		 1fohA-3vvaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		3 / 3 VAL A 125
ALA A 126
HIS A 165
 None
OH  A 503 ( 3.7A)
FE  A 501 (-3.3A)
 0.76A 1q23H-3vvaA:
undetectable		 1q23H-3vvaA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		3 / 3 VAL A 125
ALA A 126
HIS A 165
 None
OH  A 503 ( 3.7A)
FE  A 501 (-3.3A)
 0.68A 1q23G-3vvaA:
undetectable		 1q23G-3vvaA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		3 / 3 VAL A 125
ALA A 126
HIS A 165
 None
OH  A 503 ( 3.7A)
FE  A 501 (-3.3A)
 0.66A 1q23J-3vvaA:
undetectable		 1q23J-3vvaA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		6 / 11 GLU A 162
HIS A 165
LEU A 212
GLU A 213
ILE A 262
GLU A 266
 FE  A 501 (-2.4A)
FE  A 501 (-3.3A)
CHW  A 504 (-4.1A)
FE  A 502 (-2.1A)
None
OH  A 503 (-2.3A)
 0.95A 1rnrA-3vvaA:
8.1		 1rnrA-3vvaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		5 / 12 GLU A 162
HIS A 165
GLU A 213
ILE A 262
GLU A 266
 FE  A 501 (-2.4A)
FE  A 501 (-3.3A)
FE  A 502 (-2.1A)
None
OH  A 503 (-2.3A)
 0.80A 1rnrB-3vvaA:
6.6		 1rnrB-3vvaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		5 / 12 GLU A 162
HIS A 165
LEU A 212
GLU A 213
GLU A 266
 FE  A 501 (-2.4A)
FE  A 501 (-3.3A)
CHW  A 504 (-4.1A)
FE  A 502 (-2.1A)
OH  A 503 (-2.3A)
 0.92A 1rnrB-3vvaA:
6.6		 1rnrB-3vvaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		5 / 12 ALA A 226
ILE A 227
ILE A 110
VAL A 115
LEU A 172
 None
 0.82A 1uduB-3vvaA:
undetectable		 1uduB-3vvaA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 7 LEU A 294
HIS A 206
THR A 154
HIS A 280
 None
 0.94A 1v55C-3vvaA:
3.9
1v55N-3vvaA:
1.4
1v55P-3vvaA:
3.9		 1v55C-3vvaA:
20.30
1v55N-3vvaA:
20.69
1v55P-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		5 / 12 ALA A 226
ILE A 227
ILE A 110
VAL A 115
LEU A 172
 None
 0.84A 1xozA-3vvaA:
undetectable		 1xozA-3vvaA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		3 / 3 LYS A 295
ASP A  56
ASP A  61
 None
 0.94A 2br4D-3vvaA:
undetectable		 2br4D-3vvaA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 7 ARG A 173
GLU A 171
LYS A 236
PRO A 240
 None
 1.07A 2ejgA-3vvaA:
undetectable		 2ejgA-3vvaA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		5 / 12 VAL A 242
ILE A 259
ILE A 262
VAL A 115
PHE A 169
 None
 1.28A 2ft9A-3vvaA:
undetectable		 2ft9A-3vvaA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		3 / 3 GLU A 215
HIS A  77
GLU A 214
 None
 0.80A 2x45B-3vvaA:
undetectable		 2x45B-3vvaA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		3 / 3 GLU A 215
HIS A  77
GLU A 214
 None
 0.87A 2x45C-3vvaA:
undetectable		 2x45C-3vvaA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		3 / 3 MET A 164
VAL A 209
GLU A 268
 None
 0.92A 2x9gA-3vvaA:
undetectable		 2x9gA-3vvaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 5 ARG A 231
ALA A 226
ASP A 228
GLU A 229
 None
 1.43A 2xrzA-3vvaA:
undetectable		 2xrzA-3vvaA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		3 / 3 VAL A 157
ASN A 289
TRP A 151
 None
 1.11A 2y00B-3vvaA:
undetectable		 2y00B-3vvaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 4 VAL A 157
VAL A 288
ASN A 289
TRP A 151
 None
 1.36A 2y01B-3vvaA:
1.5		 2y01B-3vvaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 LEU A 294
HIS A 206
THR A 154
HIS A 280
 None
 0.97A 2y69C-3vvaA:
3.6
2y69N-3vvaA:
1.5
2y69P-3vvaA:
3.6		 2y69C-3vvaA:
20.30
2y69N-3vvaA:
20.69
2y69P-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 HIS A 206
THR A 154
HIS A 280
LEU A 294
 None
 0.88A 3ablA-3vvaA:
1.5
3ablC-3vvaA:
3.5
3ablP-3vvaA:
3.5		 3ablA-3vvaA:
20.69
3ablC-3vvaA:
20.30
3ablP-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 LEU A 294
HIS A 206
THR A 154
HIS A 280
 None
 0.92A 3ablC-3vvaA:
3.5
3ablN-3vvaA:
1.5
3ablP-3vvaA:
3.5		 3ablC-3vvaA:
20.30
3ablN-3vvaA:
20.69
3ablP-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 HIS A 206
THR A 154
HIS A 280
LEU A 294
 None
 0.88A 3abmA-3vvaA:
2.2
3abmC-3vvaA:
3.6
3abmP-3vvaA:
3.6		 3abmA-3vvaA:
20.69
3abmC-3vvaA:
20.30
3abmP-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 LEU A 294
HIS A 206
THR A 154
HIS A 280
 None
 0.91A 3asnC-3vvaA:
3.5
3asnN-3vvaA:
1.5
3asnP-3vvaA:
3.5		 3asnC-3vvaA:
20.30
3asnN-3vvaA:
20.69
3asnP-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 HIS A 206
THR A 154
HIS A 280
LEU A 294
 None
 0.92A 3asoA-3vvaA:
undetectable
3asoC-3vvaA:
3.6
3asoP-3vvaA:
3.6		 3asoA-3vvaA:
20.69
3asoC-3vvaA:
20.30
3asoP-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 LEU A 294
HIS A 206
THR A 154
HIS A 280
 None
 0.91A 3asoC-3vvaA:
3.6
3asoN-3vvaA:
undetectable
3asoP-3vvaA:
3.6		 3asoC-3vvaA:
20.30
3asoN-3vvaA:
20.69
3asoP-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		5 / 12 ASN A 289
GLY A 150
ASN A 273
VAL A 209
GLY A 133
 None
 1.01A 3k13B-3vvaA:
undetectable		 3k13B-3vvaA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 HIS A 206
THR A 154
HIS A 280
LEU A 294
 None
 0.85A 3wg7A-3vvaA:
1.5
3wg7C-3vvaA:
3.6
3wg7P-3vvaA:
3.5		 3wg7A-3vvaA:
20.69
3wg7C-3vvaA:
20.30
3wg7P-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 LEU A 294
HIS A 206
THR A 154
HIS A 280
 None
 0.89A 3wg7C-3vvaA:
3.6
3wg7N-3vvaA:
1.5
3wg7P-3vvaA:
3.5		 3wg7C-3vvaA:
20.30
3wg7N-3vvaA:
20.69
3wg7P-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 HIS A 206
THR A 154
HIS A 280
LEU A 294
 None
 0.80A 3x2qA-3vvaA:
1.4
3x2qC-3vvaA:
3.6
3x2qP-3vvaA:
3.6		 3x2qA-3vvaA:
20.69
3x2qC-3vvaA:
20.30
3x2qP-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 LEU A 294
HIS A 206
THR A 154
HIS A 280
 None
 0.91A 3x2qC-3vvaA:
3.6
3x2qN-3vvaA:
1.5
3x2qP-3vvaA:
3.6		 3x2qC-3vvaA:
20.30
3x2qN-3vvaA:
20.69
3x2qP-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		3 / 3 PRO A  63
ASN A 161
HIS A 165
 None
None
FE  A 501 (-3.3A)
 0.90A 4ma3H-3vvaA:
undetectable
4ma3L-3vvaA:
undetectable		 4ma3H-3vvaA:
22.32
4ma3L-3vvaA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 HIS A 206
THR A 154
HIS A 280
LEU A 294
 None
 0.87A 5b1aA-3vvaA:
1.5
5b1aC-3vvaA:
3.6
5b1aP-3vvaA:
3.6		 5b1aA-3vvaA:
20.69
5b1aC-3vvaA:
20.30
5b1aP-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 HIS A 206
THR A 154
HIS A 280
LEU A 294
 None
 0.89A 5b3sA-3vvaA:
1.5
5b3sC-3vvaA:
3.6
5b3sP-3vvaA:
3.6		 5b3sA-3vvaA:
20.69
5b3sC-3vvaA:
20.30
5b3sP-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 LEU A 294
HIS A 206
THR A 154
HIS A 280
 None
 0.90A 5iy5C-3vvaA:
3.6
5iy5N-3vvaA:
1.5
5iy5P-3vvaA:
3.9		 5iy5C-3vvaA:
20.61
5iy5N-3vvaA:
20.69
5iy5P-3vvaA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		5 / 12 MET A 190
PHE A 208
VAL A 128
LEU A 212
VAL A  92
 CHW  A 504 ( 4.8A)
None
None
CHW  A 504 (-4.1A)
None
 1.15A 5tudD-3vvaA:
3.3		 5tudD-3vvaA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 HIS A 206
THR A 154
HIS A 280
LEU A 294
 None
 0.98A 5w97A-3vvaA:
1.5
5w97C-3vvaA:
3.4
5w97c-3vvaA:
3.4		 5w97A-3vvaA:
20.69
5w97C-3vvaA:
20.30
5w97c-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 7 LEU A 294
HIS A 206
THR A 154
HIS A 280
 None
 0.93A 5w97C-3vvaA:
3.4
5w97a-3vvaA:
1.5
5w97c-3vvaA:
3.4		 5w97C-3vvaA:
20.30
5w97a-3vvaA:
20.69
5w97c-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 HIS A 206
THR A 154
HIS A 280
LEU A 294
 None
 0.87A 5wauA-3vvaA:
1.9
5wauC-3vvaA:
3.6
5wauc-3vvaA:
3.6		 5wauA-3vvaA:
20.69
5wauC-3vvaA:
20.30
5wauc-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 7 LEU A 294
HIS A 206
THR A 154
HIS A 280
 None
 0.89A 5wauC-3vvaA:
3.9
5waua-3vvaA:
1.9
5wauc-3vvaA:
3.9		 5wauC-3vvaA:
20.30
5waua-3vvaA:
20.69
5wauc-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 7 HIS A 206
THR A 154
HIS A 280
LEU A 294
 None
 0.95A 5x1fA-3vvaA:
1.5
5x1fC-3vvaA:
3.5
5x1fP-3vvaA:
3.4		 5x1fA-3vvaA:
20.69
5x1fC-3vvaA:
20.30
5x1fP-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 HIS A 206
THR A 154
HIS A 280
LEU A 294
 None
 0.87A 5xdqA-3vvaA:
1.5
5xdqC-3vvaA:
3.6
5xdqP-3vvaA:
3.6		 5xdqA-3vvaA:
20.69
5xdqC-3vvaA:
20.30
5xdqP-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 LEU A 294
HIS A 206
THR A 154
HIS A 280
 None
 0.92A 5xdqC-3vvaA:
3.6
5xdqN-3vvaA:
1.5
5xdqP-3vvaA:
3.6		 5xdqC-3vvaA:
20.30
5xdqN-3vvaA:
20.69
5xdqP-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 LEU A 294
HIS A 206
THR A 154
HIS A 280
 None
 0.91A 5xdxC-3vvaA:
3.5
5xdxN-3vvaA:
1.5
5xdxP-3vvaA:
3.6		 5xdxC-3vvaA:
20.61
5xdxN-3vvaA:
20.69
5xdxP-3vvaA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 HIS A 206
THR A 154
HIS A 280
LEU A 294
 None
 0.89A 5z84A-3vvaA:
1.5
5z84C-3vvaA:
3.6
5z84P-3vvaA:
3.6		 5z84A-3vvaA:
20.69
5z84C-3vvaA:
20.30
5z84P-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 7 LEU A 294
HIS A 206
THR A 154
HIS A 280
 None
 0.91A 5z84C-3vvaA:
3.9
5z84N-3vvaA:
1.5
5z84P-3vvaA:
3.9		 5z84C-3vvaA:
20.30
5z84N-3vvaA:
20.69
5z84P-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 HIS A 206
THR A 154
HIS A 280
LEU A 294
 None
 0.87A 5z85A-3vvaA:
1.5
5z85C-3vvaA:
3.6
5z85P-3vvaA:
3.6		 5z85A-3vvaA:
20.69
5z85C-3vvaA:
20.30
5z85P-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 7 LEU A 294
HIS A 206
THR A 154
HIS A 280
 None
 0.91A 5z85C-3vvaA:
3.9
5z85N-3vvaA:
1.5
5z85P-3vvaA:
3.9		 5z85C-3vvaA:
20.30
5z85N-3vvaA:
20.69
5z85P-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 HIS A 206
THR A 154
HIS A 280
LEU A 294
 None
 0.85A 5z86A-3vvaA:
1.5
5z86C-3vvaA:
3.6
5z86P-3vvaA:
3.6		 5z86A-3vvaA:
20.69
5z86C-3vvaA:
20.30
5z86P-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 LEU A 294
HIS A 206
THR A 154
HIS A 280
 None
 0.91A 5z86C-3vvaA:
3.6
5z86N-3vvaA:
2.0
5z86P-3vvaA:
3.6		 5z86C-3vvaA:
20.30
5z86N-3vvaA:
20.69
5z86P-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 HIS A 206
THR A 154
HIS A 280
LEU A 294
 None
 0.87A 5zcoA-3vvaA:
1.8
5zcoC-3vvaA:
3.6
5zcoP-3vvaA:
3.5		 5zcoA-3vvaA:
20.69
5zcoC-3vvaA:
20.30
5zcoP-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 LEU A 294
HIS A 206
THR A 154
HIS A 280
 None
 0.93A 5zcoC-3vvaA:
3.6
5zcoN-3vvaA:
1.5
5zcoP-3vvaA:
3.5		 5zcoC-3vvaA:
20.30
5zcoN-3vvaA:
20.69
5zcoP-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 HIS A 206
THR A 154
HIS A 280
LEU A 294
 None
 0.89A 5zcpA-3vvaA:
1.9
5zcpC-3vvaA:
3.6
5zcpP-3vvaA:
3.6		 5zcpA-3vvaA:
20.69
5zcpC-3vvaA:
20.30
5zcpP-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 LEU A 294
HIS A 206
THR A 154
HIS A 280
 None
 0.92A 5zcpC-3vvaA:
3.6
5zcpN-3vvaA:
1.5
5zcpP-3vvaA:
3.6		 5zcpC-3vvaA:
20.30
5zcpN-3vvaA:
20.69
5zcpP-3vvaA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL
(Trypanosoma
brucei) 		4 / 8 HIS A 206
THR A 154
HIS A 280
LEU A 294
 None
 0.86A 5zcqA-3vvaA:
2.4
5zcqC-3vvaA:
3.6
5zcqP-3vvaA:
3.6		 5zcqA-3vvaA:
20.69
5zcqC-3vvaA:
20.30
5zcqP-3vvaA:
20.30