SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vvc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 3vvc CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP8E
(Staphylococcus
aureus) 		4 / 5 GLY A 165
ASP A 125
ARG A 197
GLN A  85
 NAP  A 401 (-4.2A)
None
None
None
 1.25A 3qx3A-3vvcA:
undetectable		 3qx3A-3vvcA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 3vvc CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP8E
(Staphylococcus
aureus) 		4 / 5 GLY A 165
ASP A 125
ARG A 197
GLN A  85
 NAP  A 401 (-4.2A)
None
None
None
 1.33A 3qx3B-3vvcA:
undetectable		 3qx3B-3vvcA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3vvc CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP8E
(Staphylococcus
aureus) 		5 / 12 GLY A  12
HIS A  79
SER A  36
GLN A  42
GLU A  31
 None
None
NAP  A 401 (-2.4A)
None
None
 1.41A 3tkaA-3vvcA:
8.1		 3tkaA-3vvcA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3vvc CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP8E
(Staphylococcus
aureus) 		3 / 3 LYS A  55
TYR A  57
ARG A  33
 None
 1.21A 4gc9A-3vvcA:
5.1		 4gc9A-3vvcA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 3vvc CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP8E
(Staphylococcus
aureus) 		5 / 12 ILE A 175
ALA A 235
ASP A 245
LEU A 334
ILE A 179
 None
 1.02A 4m2xE-3vvcA:
3.0		 4m2xE-3vvcA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 3vvc CAPSULAR
POLYSACCHARIDE
SYNTHESIS ENZYME
CAP8E
(Staphylococcus
aureus) 		3 / 3 ILE A  58
MET A  71
ASP A  63
 None
 0.85A 5h2uA-3vvcA:
undetectable		 5h2uA-3vvcA:
20.37