SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vw5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		4 / 6 GLU A 246
THR A 190
TYR A 117
TYR A 110
 None
 1.24A 1qvuA-3vw5A:
undetectable		 1qvuA-3vw5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		5 / 12 THR A 300
ASN A 290
VAL A 305
GLY A 242
ALA A 309
 None
 1.25A 2x2iA-3vw5A:
undetectable		 2x2iA-3vw5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		5 / 12 THR A 300
ASN A 290
VAL A 305
GLY A 242
ALA A 309
 None
 1.21A 2x2iC-3vw5A:
undetectable		 2x2iC-3vw5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		4 / 6 TYR A 117
TYR A 373
CYH A 371
ILE A  48
 None
 1.48A 2xz5A-3vw5A:
undetectable
2xz5B-3vw5A:
undetectable		 2xz5A-3vw5A:
19.74
2xz5B-3vw5A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		3 / 3 TYR A 373
GLU A 308
ASN A 315
 None
 0.97A 2y7hC-3vw5A:
undetectable		 2y7hC-3vw5A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		4 / 8 THR A 248
ARG A 385
LEU A 183
GLU A 381
 None
 0.84A 2zw9A-3vw5A:
undetectable		 2zw9A-3vw5A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		3 / 3 ARG A 253
THR A 248
TRP A 249
 None
 1.06A 4d7hA-3vw5A:
undetectable		 4d7hA-3vw5A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		4 / 6 PHE A  56
ALA A  60
LEU A  10
THR A  11
 None
 1.02A 4dtzA-3vw5A:
undetectable		 4dtzA-3vw5A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		4 / 6 PHE A  56
ALA A  60
LEU A  10
THR A  11
 None
 1.00A 4dtzB-3vw5A:
undetectable		 4dtzB-3vw5A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		3 / 3 TYR A 373
HIS A 374
ARG A 377
 None
 0.97A 4e7bC-3vw5A:
undetectable		 4e7bC-3vw5A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		5 / 12 GLY A 242
LEU A 183
ASN A 315
SER A 275
ILE A 274
 None
 1.09A 4pb1A-3vw5A:
undetectable		 4pb1A-3vw5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		5 / 12 GLY A 242
LEU A 183
ASN A 315
SER A 275
ILE A 274
 None
 1.09A 4pd5A-3vw5A:
0.7		 4pd5A-3vw5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		4 / 6 ASN A  59
MET A 380
GLU A 381
GLU A 187
 None
 1.29A 4r87H-3vw5A:
undetectable		 4r87H-3vw5A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		4 / 6 TYR A 110
ASN A 111
GLU A 187
TYR A 373
 None
 1.26A 4twdD-3vw5A:
2.5
4twdE-3vw5A:
2.5		 4twdD-3vw5A:
22.06
4twdE-3vw5A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		4 / 6 TYR A 110
ASN A 111
GLU A 187
TYR A 373
 None
 1.24A 4twdG-3vw5A:
0.4
4twdH-3vw5A:
undetectable		 4twdG-3vw5A:
22.06
4twdH-3vw5A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		3 / 3 ARG A 253
THR A 248
TRP A 249
 None
 1.04A 4uglA-3vw5A:
undetectable		 4uglA-3vw5A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		5 / 12 GLU A  78
GLY A  28
LEU A 119
LEU A 138
ARG A 137
 None
 1.04A 4wcxC-3vw5A:
2.2		 4wcxC-3vw5A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		4 / 7 ILE A 112
LEU A 138
GLY A  90
GLY A  91
 None
 0.79A 5a06A-3vw5A:
undetectable		 5a06A-3vw5A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		4 / 7 ILE A 112
LEU A 138
GLY A  90
GLY A  91
 None
 0.80A 5a06C-3vw5A:
undetectable		 5a06C-3vw5A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		4 / 7 ILE A 112
LEU A 138
GLY A  90
GLY A  91
 None
 0.78A 5a06E-3vw5A:
undetectable		 5a06E-3vw5A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		4 / 7 ILE A 112
LEU A 138
GLY A  90
GLY A  91
 None
 0.81A 5a06F-3vw5A:
undetectable		 5a06F-3vw5A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		5 / 12 LEU A  49
ASN A 375
LEU A  10
PHE A  56
ILE A  14
 None
 1.24A 5dv4A-3vw5A:
undetectable		 5dv4A-3vw5A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		4 / 6 GLY A 346
GLU A 345
PHE A  17
ILE A 341
 None
 0.89A 5kmfA-3vw5A:
undetectable
5kmfC-3vw5A:
undetectable		 5kmfA-3vw5A:
20.88
5kmfC-3vw5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		4 / 8 GLY A  66
LEU A  69
SER A  58
ALA A 125
 None
 0.93A 5xu8A-3vw5A:
undetectable		 5xu8A-3vw5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		5 / 10 VAL A  47
LEU A  49
LEU A 119
GLY A 100
VAL A  92
 None
 1.19A 6eu9B-3vw5A:
undetectable		 6eu9B-3vw5A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 3vw5 CELLOBIOSE
2-EPIMERASE
(Ruminococcus
albus) 		5 / 10 VAL A  47
SER A  51
LEU A 119
GLY A 100
VAL A  92
 None
 1.11A 6eu9B-3vw5A:
undetectable		 6eu9B-3vw5A:
12.82