SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vw7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 11 CYH A 365
SER A 116
LEU A 117
VAL A 152
ILE A 159
 OLC  A2005 (-3.5A)
None
None
None
OLC  A2004 ( 4.3A)
 1.32A 1ee2B-3vw7A:
undetectable		 1ee2B-3vw7A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 7 VAL A 139
VAL A 195
TYR A 187
CYH A 184
 OLC  A2008 (-4.6A)
None
None
None
 1.26A 1t46A-3vw7A:
undetectable		 1t46A-3vw7A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 8 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.07A 2xytE-3vw7A:
undetectable		 2xytE-3vw7A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 8 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.02A 2xytH-3vw7A:
undetectable		 2xytH-3vw7A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 7 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.03A 2xytI-3vw7A:
undetectable		 2xytI-3vw7A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 10 CYH A 365
ILE A 366
ILE A 362
VAL A 108
GLY A 111
 OLC  A2005 (-3.5A)
None
OLC  A2005 ( 4.4A)
None
OLC  A2005 ( 4.6A)
 1.12A 3em0A-3vw7A:
undetectable		 3em0A-3vw7A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 10 CYH A 365
ILE A 366
VAL A 108
GLY A 111
LEU A 119
 OLC  A2005 (-3.5A)
None
None
OLC  A2005 ( 4.6A)
None
 1.23A 3em0A-3vw7A:
undetectable		 3em0A-3vw7A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.24A 3peoG-3vw7A:
undetectable		 3peoG-3vw7A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 LEU A 354
SER A  93
TYR A  95
THR A 102
THR A  97
 None
 1.42A 3thrA-3vw7A:
undetectable
3thrB-3vw7A:
undetectable
3thrC-3vw7A:
undetectable
3thrD-3vw7A:
undetectable		 3thrA-3vw7A:
20.93
3thrB-3vw7A:
20.93
3thrC-3vw7A:
20.93
3thrD-3vw7A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 5 LEU A 333
LEU A 332
LEU A 340
SER A 341
 VPX  A2001 (-4.9A)
OLC  A2007 (-4.6A)
VPX  A2001 ( 4.7A)
None
 0.71A 3vhuA-3vw7A:
undetectable		 3vhuA-3vw7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 LEU A 229
ALA A 225
LEU A 191
THR A 222
 OLC  A2010 (-4.2A)
OLC  A2010 ( 3.8A)
OLC  A2010 ( 4.5A)
OLC  A2010 (-3.7A)
 1.00A 4ikiB-3vw7A:
undetectable		 4ikiB-3vw7A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 SER A 360
GLY A 327
ASN A 330
ILE A 321
 None
OLC  A2007 (-3.6A)
None
None
 1.14A 5j4nA-3vw7A:
undetectable		 5j4nA-3vw7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 SER A 300
ASP A1072
VAL A1071
VAL A1094
ALA A1093
 None
 1.02A 5kocA-3vw7A:
undetectable		 5kocA-3vw7A:
20.72