SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vwa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  34
PHE A  47
VAL A  95
 None
 0.66A 1kijB-3vwaA:
undetectable		 1kijB-3vwaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 140
LEU A 120
SER A 118
LEU A 115
TYR A 248
 None
 1.47A 1mmkA-3vwaA:
undetectable		 1mmkA-3vwaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 389
LEU A 405
VAL A 412
ILE A 411
 None
 0.96A 1t87B-3vwaA:
undetectable		 1t87B-3vwaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  74
LEU A 150
SER A 139
THR A 134
 None
 1.29A 1tyrA-3vwaA:
undetectable		 1tyrA-3vwaA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 4 ASP A 358
LEU A 329
LEU A 364
LEU A 325
 None
 1.38A 1u18A-3vwaA:
undetectable		 1u18A-3vwaA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 230
ASP A 191
ASP A 186
 None
 0.80A 2ejtA-3vwaA:
undetectable		 2ejtA-3vwaA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 194
LEU A 198
ILE A 199
PHE A 229
LEU A 121
 None
 0.99A 2f8dA-3vwaA:
undetectable		 2f8dA-3vwaA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 194
LEU A 198
ILE A 199
PHE A 229
LEU A 121
 None
 1.01A 2f8dB-3vwaA:
undetectable		 2f8dB-3vwaA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 329
LEU A 325
ILE A 308
SER A 310
 None
 1.06A 2hc4A-3vwaA:
undetectable		 2hc4A-3vwaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 367
ILE A 300
ILE A 350
LEU A 372
THR A 336
 None
 1.16A 2qo5A-3vwaA:
undetectable		 2qo5A-3vwaA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 239
GLN A 249
TRP A 148
 None
 1.15A 2vqyA-3vwaA:
undetectable		 2vqyA-3vwaA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 HIS A   7
ASP A  84
SER A  87
ILE A  10
 None
 1.08A 2xadA-3vwaA:
undetectable		 2xadA-3vwaA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 HIS A   7
ASP A  84
SER A  87
ILE A  10
 None
 1.10A 2xadB-3vwaA:
undetectable		 2xadB-3vwaA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 HIS A   7
ASP A  84
SER A  87
ILE A  10
 None
 1.07A 2xadC-3vwaA:
undetectable		 2xadC-3vwaA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 HIS A   7
ASP A  84
SER A  87
ILE A  10
 None
 1.08A 2xadD-3vwaA:
undetectable		 2xadD-3vwaA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 485
ARG A 522
GLY A 521
ALA A 523
 None
 0.94A 2xfsA-3vwaA:
undetectable		 2xfsA-3vwaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 485
ARG A 522
GLY A 521
ALA A 523
 None
 0.93A 2xh9A-3vwaA:
undetectable		 2xh9A-3vwaA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 331
LEU A 325
LEU A 296
ILE A 300
LEU A 364
 None
 1.31A 3a50C-3vwaA:
2.1		 3a50C-3vwaA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 283
ILE A 288
GLY A 286
LEU A 244
GLU A 147
 None
 1.13A 3ai9X-3vwaA:
undetectable		 3ai9X-3vwaA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 THR A 404
THR A 407
LEU A 365
ILE A 381
ILE A 385
 None
 1.21A 3gwxA-3vwaA:
undetectable		 3gwxA-3vwaA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  98
GLU A 114
ASN A 242
ILE A 199
GLY A 116
 None
 1.28A 3ps9A-3vwaA:
undetectable		 3ps9A-3vwaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 376
GLY A 374
PHE A 342
PHE A 346
 None
 1.12A 3smtA-3vwaA:
undetectable		 3smtA-3vwaA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 488
LEU A 526
GLU A 529
TYR A 530
 None
 1.05A 4f3tA-3vwaA:
undetectable		 4f3tA-3vwaA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 SER A 139
PHE A 167
LEU A 182
GLY A 194
MET A 193
 None
 1.36A 4zjlA-3vwaA:
undetectable		 4zjlA-3vwaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 191
ASN A 188
PHE A 126
 None
 0.71A 5jglB-3vwaA:
undetectable		 5jglB-3vwaA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 242
GLU A 237
TRP A 239
TRP A 212
 None
 1.43A 5oh1C-3vwaA:
undetectable		 5oh1C-3vwaA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 3vwa CYTOPLASMIC EXPORT
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 195
PHE A  98
LEU A 106
GLY A 112
 None
 0.66A 6eu9D-3vwaA:
undetectable		 6eu9D-3vwaA:
9.78