SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vwo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		4 / 7 ARG A 233
GLU A 219
LYS A 208
ALA A 209
 None
None
EPE  A 401 ( 4.3A)
None
 1.10A 2ejgA-3vwoA:
undetectable		 2ejgA-3vwoA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		5 / 12 HIS A 176
TYR A 281
PHE A 272
ALA A 182
LEU A 204
 None
EPE  A 401 (-3.4A)
None
None
None
 1.24A 3n8xA-3vwoA:
undetectable		 3n8xA-3vwoA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		5 / 12 GLY A 189
SER A 191
ALA A 182
VAL A 179
ARG A 303
 None
 1.18A 4dx5B-3vwoA:
undetectable		 4dx5B-3vwoA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		6 / 11 ALA A 168
ALA A 165
ALA A 164
THR A 160
VAL A 157
LEU A 300
 None
 1.38A 4j6cA-3vwoA:
undetectable		 4j6cA-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		6 / 11 GLN A 169
ALA A 168
ALA A 164
THR A 160
VAL A 157
LEU A 304
 None
 1.04A 4j6cA-3vwoA:
undetectable		 4j6cA-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		6 / 11 GLN A 169
ALA A 168
ALA A 165
ALA A 164
THR A 160
VAL A 157
 None
 1.36A 4j6cA-3vwoA:
undetectable		 4j6cA-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		6 / 10 ALA A 168
ALA A 165
ALA A 164
THR A 160
VAL A 157
LEU A 300
 None
 1.37A 4j6cB-3vwoA:
undetectable		 4j6cB-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		6 / 10 GLN A 169
ALA A 168
ALA A 164
THR A 160
VAL A 157
LEU A 304
 None
 1.03A 4j6cB-3vwoA:
undetectable		 4j6cB-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		6 / 10 GLN A 169
ALA A 168
ALA A 165
ALA A 164
THR A 160
VAL A 157
 None
 1.34A 4j6cB-3vwoA:
undetectable		 4j6cB-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		7 / 12 GLN A 169
ALA A 168
ALA A 165
ALA A 164
THR A 160
VAL A 157
LEU A 304
 None
 1.38A 4j6dA-3vwoA:
undetectable		 4j6dA-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		5 / 12 ALA A 168
ALA A 164
THR A 160
VAL A 157
LEU A 304
 None
 1.07A 4j6dB-3vwoA:
undetectable		 4j6dB-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		5 / 12 GLN A 169
ALA A 168
ALA A 164
VAL A 157
LEU A 304
 None
 0.91A 4j6dB-3vwoA:
undetectable		 4j6dB-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		6 / 12 ALA A 168
ALA A 165
ALA A 164
THR A 160
VAL A 157
LEU A 300
 None
 1.33A 4jbtA-3vwoA:
undetectable		 4jbtA-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		6 / 12 GLN A 169
ALA A 168
ALA A 164
THR A 160
VAL A 157
LEU A 304
 None
 1.02A 4jbtA-3vwoA:
undetectable		 4jbtA-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		6 / 12 GLN A 169
ALA A 168
ALA A 165
ALA A 164
THR A 160
VAL A 157
 None
 1.39A 4jbtA-3vwoA:
undetectable		 4jbtA-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		6 / 11 ALA A 168
ALA A 165
ALA A 164
THR A 160
VAL A 157
LEU A 300
 None
 1.34A 4jbtB-3vwoA:
undetectable		 4jbtB-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		6 / 11 GLN A 169
ALA A 168
ALA A 164
THR A 160
VAL A 157
LEU A 304
 None
 1.03A 4jbtB-3vwoA:
undetectable		 4jbtB-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		6 / 11 GLN A 169
ALA A 168
ALA A 165
ALA A 164
THR A 160
VAL A 157
 None
 1.41A 4jbtB-3vwoA:
undetectable		 4jbtB-3vwoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		6 / 12 GLY A 189
SER A 191
ALA A 182
PHE A 247
VAL A 179
ARG A 303
 None
 1.36A 4u8vB-3vwoA:
undetectable		 4u8vB-3vwoA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		6 / 12 GLY A 189
SER A 191
ALA A 182
PHE A 247
VAL A 179
ARG A 303
 None
 1.35A 4u8yB-3vwoA:
undetectable		 4u8yB-3vwoA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		3 / 3 SER A 242
TYR A 240
TYR A 202
 None
 0.80A 5lakA-3vwoA:
undetectable
5lakI-3vwoA:
undetectable		 5lakA-3vwoA:
17.98
5lakI-3vwoA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ
(Sphingomonas
sp.
A1) 		3 / 3 SER A 242
TYR A 240
TYR A 202
 None
 0.77A 5lakC-3vwoA:
undetectable
5lakJ-3vwoA:
undetectable		 5lakC-3vwoA:
17.98
5lakJ-3vwoA:
3.90