SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vx6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 3vx6 E1
(Kluyveromyces
marxianus) 		5 / 9 SER A 219
ILE A 245
ALA A 146
GLY A 101
LEU A 253
 None
 1.19A 2v0mB-3vx6A:
undetectable		 2v0mB-3vx6A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 3vx6 E1
(Kluyveromyces
marxianus) 		5 / 12 GLN A 142
GLY A 108
ALA A 146
SER A 140
ILE A 173
 None
 0.92A 2v0zO-3vx6A:
undetectable		 2v0zO-3vx6A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3vx6 E1
(Kluyveromyces
marxianus) 		4 / 8 ILE A 173
LEU A  46
ILE A 117
PHE A 197
 None
 0.82A 2w9sE-3vx6A:
undetectable		 2w9sE-3vx6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 3vx6 E1
(Kluyveromyces
marxianus) 		5 / 10 ILE A 150
ALA A 241
ILE A 117
ILE A 181
THR A 228
 None
 1.18A 3prsA-3vx6A:
undetectable		 3prsA-3vx6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 3vx6 E1
(Kluyveromyces
marxianus) 		3 / 3 PHE A 124
LYS A  27
SER A  24
 None
 1.25A 3tyeB-3vx6A:
undetectable		 3tyeB-3vx6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3vx6 E1
(Kluyveromyces
marxianus) 		5 / 12 ILE A  97
ILE A 122
VAL A  15
LEU A  58
PHE A  14
 None
 1.04A 3w67B-3vx6A:
undetectable		 3w67B-3vx6A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3vx6 E1
(Kluyveromyces
marxianus) 		4 / 8 ASP A 161
ILE A 162
LYS A 194
ILE A 181
 None
 0.91A 4kttB-3vx6A:
undetectable		 4kttB-3vx6A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3vx6 E1
(Kluyveromyces
marxianus) 		4 / 8 ASP A 161
ILE A 162
LYS A 194
ILE A 181
 None
 0.89A 4kttD-3vx6A:
undetectable		 4kttD-3vx6A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3vx6 E1
(Kluyveromyces
marxianus) 		4 / 8 ASP A 161
ILE A 162
LYS A 194
ILE A 181
 None
 0.93A 4ndnD-3vx6A:
undetectable		 4ndnD-3vx6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3vx6 E1
(Kluyveromyces
marxianus) 		4 / 7 GLU A 240
TYR A 227
GLU A 242
ARG A 224
 None
 1.30A 4r87J-3vx6A:
undetectable
4r87L-3vx6A:
undetectable		 4r87J-3vx6A:
21.51
4r87L-3vx6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3vx6 E1
(Kluyveromyces
marxianus) 		4 / 5 TYR A 134
LYS A 269
PRO A 268
GLU A 259
 None
 1.13A 4w5tA-3vx6A:
undetectable		 4w5tA-3vx6A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3vx6 E1
(Kluyveromyces
marxianus) 		4 / 6 TYR A 134
LYS A 269
PRO A 268
GLU A 259
 None
 1.13A 4z4cA-3vx6A:
undetectable		 4z4cA-3vx6A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3vx6 E1
(Kluyveromyces
marxianus) 		4 / 6 TYR A 134
LYS A 269
PRO A 268
GLU A 259
 None
 1.11A 4z4gA-3vx6A:
undetectable		 4z4gA-3vx6A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 3vx6 E1
(Kluyveromyces
marxianus) 		4 / 8 ILE A 214
LEU A 113
ILE A 229
ARG A 224
 None
 0.66A 4zvcA-3vx6A:
undetectable
4zvcB-3vx6A:
undetectable		 4zvcA-3vx6A:
19.23
4zvcB-3vx6A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 3vx6 E1
(Kluyveromyces
marxianus) 		4 / 8 ILE A 229
ARG A 224
ILE A 214
LEU A 113
 None
 0.66A 4zvcA-3vx6A:
undetectable
4zvcB-3vx6A:
undetectable		 4zvcA-3vx6A:
19.23
4zvcB-3vx6A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3vx6 E1
(Kluyveromyces
marxianus) 		4 / 6 SER A 219
GLY A 248
ASN A 249
ILE A 244
 None
 1.02A 5j4nA-3vx6A:
undetectable		 5j4nA-3vx6A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3vx6 E1
(Kluyveromyces
marxianus) 		4 / 6 LEU A  40
SER A  62
PHE A  63
ASP A  61
 None
 1.08A 5om3A-3vx6A:
undetectable
5om3B-3vx6A:
undetectable		 5om3A-3vx6A:
15.33
5om3B-3vx6A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 3vx6 E1
(Kluyveromyces
marxianus) 		4 / 8 ILE A 243
TRP A 218
VAL A 195
ASP A 199
 None
 1.11A 5vlmF-3vx6A:
undetectable		 5vlmF-3vx6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 3vx6 E1
(Kluyveromyces
marxianus) 		3 / 3 TYR A 133
ASP A 272
ASP A 126
 None
 0.80A 5x6yA-3vx6A:
undetectable		 5x6yA-3vx6A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 3vx6 E1
(Kluyveromyces
marxianus) 		3 / 3 PHE A  49
ARG A 233
ALA A   8
 None
 0.79A 6ecfB-3vx6A:
undetectable		 6ecfB-3vx6A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3vx6 E1
(Kluyveromyces
marxianus) 		4 / 7 ASP A 161
ILE A 162
LYS A 194
ILE A 181
 None
 0.96A 6fbnA-3vx6A:
undetectable		 6fbnA-3vx6A:
22.80