SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vx8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 3vx8 AUTOPHAGY-RELATED
PROTEIN 3
(Arabidopsis
thaliana) 		5 / 8 PHE B  72
THR B 200
HIS B 252
ILE B  74
HIS B 245
 None
 1.38A 1ei6D-3vx8B:
undetectable		 1ei6D-3vx8B:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		5 / 12 VAL D 201
ASP D 200
ASP D 221
HIS D 218
SER D 132
 None
 0.82A 1ia0B-3vx8D:
undetectable		 1ia0B-3vx8D:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		5 / 12 VAL D 201
ASP D 200
ASP D 221
HIS D 218
SER D 132
 None
 0.82A 1tubB-3vx8D:
undetectable		 1tubB-3vx8D:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 7 SER D 207
ALA D 214
SER D 215
SER D 209
 None
 0.89A 2i91A-3vx8D:
undetectable		 2i91A-3vx8D:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 7 SER D 207
ALA D 214
SER D 215
SER D 209
 None
 0.90A 2i91B-3vx8D:
undetectable		 2i91B-3vx8D:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 5 PHE D  28
PHE D  24
LEU D  63
PHE D 137
 None
 1.17A 2y69C-3vx8D:
undetectable
2y69J-3vx8D:
undetectable		 2y69C-3vx8D:
17.61
2y69J-3vx8D:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 5 PHE D  28
PHE D  24
LEU D  63
PHE D 137
 None
 1.17A 2y69P-3vx8D:
undetectable
2y69W-3vx8D:
undetectable		 2y69P-3vx8D:
17.61
2y69W-3vx8D:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 5 PHE D  28
PHE D  24
LEU D  63
PHE D 137
 None
 1.21A 3abmC-3vx8D:
undetectable
3abmJ-3vx8D:
undetectable		 3abmC-3vx8D:
17.61
3abmJ-3vx8D:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 5 PHE D  28
PHE D  24
LEU D  63
PHE D 137
 None
 1.20A 3abmP-3vx8D:
undetectable
3abmW-3vx8D:
undetectable		 3abmP-3vx8D:
17.61
3abmW-3vx8D:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3vx8 AUTOPHAGY-RELATED
PROTEIN 3
(Arabidopsis
thaliana) 		4 / 5 THR B 200
SER B 198
SER B 254
ARG B 209
 None
 1.38A 3hlwB-3vx8B:
undetectable		 3hlwB-3vx8B:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 8 PHE D 177
GLU D 180
SER D 212
VAL D 208
 None
 1.22A 3jx1A-3vx8D:
undetectable
3jx1B-3vx8D:
undetectable		 3jx1A-3vx8D:
20.75
3jx1B-3vx8D:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 7 PHE D 177
GLU D 180
SER D 212
VAL D 208
 None
 1.17A 3n61A-3vx8D:
undetectable
3n61B-3vx8D:
undetectable		 3n61A-3vx8D:
20.75
3n61B-3vx8D:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		3 / 3 VAL D 185
VAL D 285
SER D 283
 None
 0.73A 3n8xB-3vx8D:
undetectable		 3n8xB-3vx8D:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 8 PHE D 177
GLU D 180
SER D 212
VAL D 208
 None
 1.17A 3nlrA-3vx8D:
undetectable
3nlrB-3vx8D:
undetectable		 3nlrA-3vx8D:
20.75
3nlrB-3vx8D:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 8 PHE D 177
GLU D 180
SER D 212
VAL D 208
 None
 1.16A 3nlyA-3vx8D:
undetectable
3nlyB-3vx8D:
undetectable		 3nlyA-3vx8D:
20.52
3nlyB-3vx8D:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 8 PHE D 177
GLU D 180
SER D 212
VAL D 208
 None
 1.18A 3rqlA-3vx8D:
undetectable
3rqlB-3vx8D:
undetectable		 3rqlA-3vx8D:
20.52
3rqlB-3vx8D:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 5 VAL D 139
LEU D  93
ILE D  45
VAL D  20
 None
 0.85A 4a9kB-3vx8D:
undetectable		 4a9kB-3vx8D:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 8 PHE D 177
GLU D 180
SER D 212
VAL D 208
 None
 1.16A 4capA-3vx8D:
undetectable
4capB-3vx8D:
undetectable		 4capA-3vx8D:
20.52
4capB-3vx8D:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 8 PHE D 177
GLU D 180
SER D 212
VAL D 208
 None
 1.18A 4d32A-3vx8D:
undetectable
4d32B-3vx8D:
undetectable		 4d32A-3vx8D:
20.52
4d32B-3vx8D:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 8 PHE D 177
GLU D 180
SER D 212
VAL D 208
 None
 1.16A 4v3yA-3vx8D:
undetectable
4v3yB-3vx8D:
undetectable		 4v3yA-3vx8D:
20.52
4v3yB-3vx8D:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 5 PHE D  28
PHE D  24
LEU D  63
PHE D 137
 None
 1.16A 5wauc-3vx8D:
undetectable
5wauj-3vx8D:
undetectable		 5wauc-3vx8D:
17.61
5wauj-3vx8D:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 7 ASP D  40
ASP D  39
GLY D  37
ASN D  97
 None
 1.07A 5x7pA-3vx8D:
undetectable		 5x7pA-3vx8D:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 5 PHE D  28
PHE D  24
LEU D  63
PHE D 137
 None
 1.13A 5xdqC-3vx8D:
undetectable
5xdqJ-3vx8D:
undetectable		 5xdqC-3vx8D:
17.61
5xdqJ-3vx8D:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 5 PHE D  28
PHE D  24
LEU D  63
PHE D 137
 None
 1.16A 5xdqP-3vx8D:
undetectable
5xdqW-3vx8D:
undetectable		 5xdqP-3vx8D:
17.61
5xdqW-3vx8D:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3vx8 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7
(Arabidopsis
thaliana) 		4 / 6 PHE D  28
PHE D  24
LEU D  63
PHE D 137
 None
 1.13A 5z86C-3vx8D:
undetectable
5z86J-3vx8D:
undetectable		 5z86C-3vx8D:
17.61
5z86J-3vx8D:
10.86