SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vxc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		3 / 3 PHE A 381
LEU A 292
SER A 376
 None
 0.87A 1e7aA-3vxcA:
undetectable		 1e7aA-3vxcA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		4 / 5 GLY A 279
LEU A 188
THR A 194
VAL A 166
 None
 1.06A 1ekjF-3vxcA:
undetectable
1ekjG-3vxcA:
undetectable		 1ekjF-3vxcA:
22.82
1ekjG-3vxcA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		5 / 12 LEU A 432
ALA A 238
ILE A 217
ILE A 415
LEU A 418
 None
 1.14A 1tw4A-3vxcA:
undetectable		 1tw4A-3vxcA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		3 / 3 ASN A 327
ILE A  98
MET A  74
 BXP  A 601 (-2.9A)
None
None
 0.70A 2h42C-3vxcA:
undetectable		 2h42C-3vxcA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		5 / 12 ALA A 238
PRO A 237
VAL A 239
THR A 396
ILE A 226
 None
 1.00A 2v95A-3vxcA:
undetectable		 2v95A-3vxcA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		4 / 7 TYR A 328
SER A 330
GLN A 401
SER A 106
 None
None
BXP  A 601 (-3.9A)
None
 1.26A 2xz5A-3vxcA:
undetectable
2xz5B-3vxcA:
undetectable		 2xz5A-3vxcA:
18.94
2xz5B-3vxcA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		4 / 7 ARG A 346
ALA A  68
ASN A 337
ALA A  70
 None
 1.14A 2zgwA-3vxcA:
undetectable		 2zgwA-3vxcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		5 / 12 ALA A 269
GLY A 258
SER A 261
GLY A 200
GLY A 199
 None
 0.94A 3douA-3vxcA:
undetectable		 3douA-3vxcA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		4 / 4 LEU A 172
ALA A 191
VAL A 193
PRO A 195
 None
 1.06A 3gv1B-3vxcA:
undetectable		 3gv1B-3vxcA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		5 / 12 PHE A 196
ALA A 197
PHE A 255
LEU A 249
GLY A 284
 None
 1.11A 4kykA-3vxcA:
undetectable
4kykB-3vxcA:
undetectable		 4kykA-3vxcA:
18.43
4kykB-3vxcA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_A_PARA500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		5 / 10 PHE A 381
THR A 290
ASP A  46
ASP A  47
GLY A 293
 None
None
BXP  A 601 (-3.1A)
None
None
 1.45A 4qb9A-3vxcA:
0.0		 4qb9A-3vxcA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		5 / 12 PHE A 381
THR A 290
ASP A  46
ASP A  47
GLY A 293
 None
None
BXP  A 601 (-3.1A)
None
None
 1.50A 4qb9E-3vxcA:
undetectable		 4qb9E-3vxcA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		5 / 11 PHE A 381
THR A 290
ASP A  46
ASP A  47
GLY A 293
 None
None
BXP  A 601 (-3.1A)
None
None
 1.48A 4qb9F-3vxcA:
undetectable		 4qb9F-3vxcA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		5 / 10 VAL A 420
GLY A 256
PHE A 259
SER A 261
GLY A 200
 None
 1.50A 4xpbA-3vxcA:
undetectable		 4xpbA-3vxcA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		5 / 11 GLY A 154
PHE A 133
ASN A 324
CYH A 326
VAL A 137
 None
None
BXP  A 601 (-3.3A)
None
None
 1.28A 5c8tB-3vxcA:
undetectable		 5c8tB-3vxcA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		5 / 12 VAL A 429
PRO A 309
PHE A 311
VAL A 322
PHE A 428
 None
 1.11A 6becA-3vxcA:
undetectable
6becB-3vxcA:
undetectable
6becC-3vxcA:
undetectable		 6becA-3vxcA:
21.06
6becB-3vxcA:
21.06
6becC-3vxcA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		5 / 10 LEU A 213
LEU A 181
ILE A 217
SER A 310
GLY A 314
 None
 1.20A 6dm0B-3vxcA:
5.7
6dm0C-3vxcA:
3.1		 6dm0B-3vxcA:
10.26
6dm0C-3vxcA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN
(Streptomyces
thermoviolaceus) 		4 / 5 TYR A 264
VAL A 250
PHE A 161
GLY A 284
 None
 1.25A 6hd4A-3vxcA:
undetectable		 6hd4A-3vxcA:
10.80