SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		3 / 3 THR B 180
GLU B 359
HIS B 202
 None
 0.88A 1xwfA-3vysB:
undetectable		 1xwfA-3vysB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		3 / 3 THR B 180
GLU B 359
HIS B 202
 None
 0.87A 1xwfB-3vysB:
undetectable		 1xwfB-3vysB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		3 / 3 THR B 180
GLU B 359
HIS B 202
 None
 0.89A 1xwfC-3vysB:
undetectable		 1xwfC-3vysB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		3 / 3 THR B 180
GLU B 359
HIS B 202
 None
 0.90A 1xwfD-3vysB:
undetectable		 1xwfD-3vysB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		3 / 3 ARG B  84
VAL B  73
THR B 106
 None
 0.77A 2nmzA-3vysB:
undetectable		 2nmzA-3vysB:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		3 / 3 ARG B  84
VAL B  73
THR B 106
 None
 0.75A 2nnkA-3vysB:
undetectable		 2nnkA-3vysB:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		5 / 12 ALA B 156
ILE B 173
LEU B 295
PHE B 274
THR B 153
 None
 0.93A 2w3vA-3vysB:
undetectable		 2w3vA-3vysB:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		3 / 3 ARG B  84
VAL B  73
THR B 106
 None
 0.82A 3cyxA-3vysB:
undetectable		 3cyxA-3vysB:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		3 / 3 ARG B  84
VAL B  73
THR B 106
 None
 0.67A 3k4vA-3vysB:
undetectable		 3k4vA-3vysB:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		3 / 3 ARG B  84
VAL B  73
THR B 106
 None
 0.82A 3ndtA-3vysB:
undetectable		 3ndtA-3vysB:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		3 / 3 ARG B  84
VAL B  73
THR B 106
 None
 0.74A 3nduD-3vysB:
undetectable		 3nduD-3vysB:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		3 / 3 ARG B  84
VAL B  73
THR B 106
 None
 0.78A 3pwrA-3vysB:
undetectable		 3pwrA-3vysB:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		3 / 3 ARG B  84
VAL B  73
THR B 106
 None
 0.70A 3tl9A-3vysB:
undetectable		 3tl9A-3vysB:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		4 / 7 VAL B  58
ILE B  32
ASN B  57
GLU B  19
 None
 0.93A 4a97E-3vysB:
undetectable		 4a97E-3vysB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		4 / 8 VAL B  58
ILE B  32
ASN B  57
GLU B  19
 None
 0.98A 4a97C-3vysB:
undetectable		 4a97C-3vysB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		4 / 8 VAL B  58
ILE B  32
ASN B  57
GLU B  19
 None
 0.97A 4a97I-3vysB:
undetectable		 4a97I-3vysB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		5 / 12 HIS B 202
THR B 205
VAL B 259
ASN B 253
GLU B 254
 None
 1.34A 4dvoA-3vysB:
undetectable		 4dvoA-3vysB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_C_ADNC403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		5 / 11 PRO B 317
ASP B 318
ASP B  75
ILE B  76
ILE B 104
 None
 1.45A 4ktvC-3vysB:
undetectable
4ktvD-3vysB:
undetectable		 4ktvC-3vysB:
23.57
4ktvD-3vysB:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		5 / 12 VAL B  37
GLY B 360
PHE B 149
THR B 180
THR B 361
 None
 1.30A 4mubA-3vysB:
undetectable		 4mubA-3vysB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		4 / 6 ASN B 170
ASP B 139
THR B 130
VAL B 142
 None
 1.04A 4yoaA-3vysB:
undetectable		 4yoaA-3vysB:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		6 / 12 ILE B  70
VAL B  37
GLY B 360
PHE B 149
THR B 180
THR B 361
 None
 1.24A 5byjA-3vysB:
undetectable		 5byjA-3vysB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		5 / 12 ILE B  70
VAL B  37
PHE B 149
THR B 180
THR B 361
 None
 1.21A 5bykA-3vysB:
undetectable		 5bykA-3vysB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		4 / 7 VAL B  61
PRO B 339
LEU B 340
PHE B 341
 None
None
SF4  B 501 ( 4.3A)
None
 1.22A 6aycA-3vysB:
undetectable		 6aycA-3vysB:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B4Y_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		5 / 10 ILE B  70
VAL B  37
PHE B 149
THR B 180
THR B 361
 None
 1.21A 6b4yA-3vysB:
0.0		 6b4yA-3vysB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD
(Thermococcus
kodakarensis) 		5 / 12 ASP B  75
ILE B  76
ILE B 104
PRO B 317
ASP B 318
 None
 1.49A 6fbpA-3vysB:
undetectable
6fbpB-3vysB:
undetectable		 6fbpA-3vysB:
12.12
6fbpB-3vysB:
12.12