SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vyw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		6 / 12 GLY A 104
GLY A 106
GLU A 133
ASP A 174
ALA A 194
LEU A 203
 SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
None
SAM  A 501 (-4.6A)
 0.77A 1jg2A-3vywA:
7.6		 1jg2A-3vywA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 11 GLY A 104
GLY A 106
GLU A 133
ASP A 174
LEU A 203
 SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-4.6A)
 0.73A 1jg3A-3vywA:
7.4		 1jg3A-3vywA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 11 GLY A 104
GLY A 106
GLU A 133
ASP A 174
LEU A 203
 SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-4.6A)
 0.73A 1jg3B-3vywA:
2.1		 1jg3B-3vywA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 TYR A  10
LEU A   7
ALA A  38
PRO A 201
ILE A 297
 None
 1.28A 1mx8A-3vywA:
undetectable		 1mx8A-3vywA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 5 GLU A 214
ARG A 284
LEU A 211
ASP A 207
 None
 1.23A 1n13B-3vywA:
undetectable
1n13C-3vywA:
undetectable		 1n13B-3vywA:
17.38
1n13C-3vywA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 6 PHE A 279
VAL A 303
LEU A 300
SER A 196
 None
 1.08A 1wrlB-3vywA:
undetectable		 1wrlB-3vywA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3vyw MNMC2
(Aquifex
aeolicus) 		3 / 3 GLY A 104
GLU A 133
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.8A)
 0.30A 2b25B-3vywA:
9.7		 2b25B-3vywA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 GLY A 104
GLY A 106
LYS A 134
ASP A 174
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
 0.90A 2pxcA-3vywA:
7.0		 2pxcA-3vywA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 11 GLY A 104
GLY A 106
GLU A 133
ASP A 174
ALA A 175
 SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
 0.61A 3dxyA-3vywA:
9.2		 3dxyA-3vywA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 6 GLY A 106
GLU A 133
GLU A 135
GLU A 202
 SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
None
SAM  A 501 (-4.2A)
 0.92A 3fpjA-3vywA:
5.5		 3fpjA-3vywA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		6 / 12 GLY A 104
GLY A 106
GLU A 133
LYS A 134
ASP A 174
ALA A 175
 SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
 0.60A 3fuuA-3vywA:
9.5		 3fuuA-3vywA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		6 / 12 VAL A 103
GLY A 104
GLY A 106
GLU A 133
LYS A 134
ASP A 174
 None
SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
 0.90A 3fuuA-3vywA:
9.5		 3fuuA-3vywA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 11 GLY A 104
GLY A 106
GLU A 133
ASP A 174
ALA A 175
 SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
 0.53A 3grvA-3vywA:
10.1		 3grvA-3vywA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 GLY A 104
GLY A 106
GLU A 133
ASP A 174
ALA A 175
 SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
 0.59A 3gryA-3vywA:
10.3		 3gryA-3vywA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		3 / 3 ASP A 193
PHE A 195
SER A  69
 SAM  A 501 (-3.8A)
SAM  A 501 (-3.7A)
None
 0.91A 3i5uB-3vywA:
8.7		 3i5uB-3vywA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 11 GLY A 104
GLU A 133
ASP A 174
ALA A 175
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.8A)
 0.67A 3id5B-3vywA:
9.0		 3id5B-3vywA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 11 GLY A 104
GLU A 133
ASP A 174
ALA A 175
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.8A)
 0.67A 3id5F-3vywA:
8.9		 3id5F-3vywA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 GLY A 104
GLU A 133
ASP A 174
ALA A 175
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.8A)
 0.58A 3id6C-3vywA:
3.5		 3id6C-3vywA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 GLY A 104
GLY A 106
GLY A 108
ASP A 174
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.1A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
 0.42A 3ihtA-3vywA:
11.5		 3ihtA-3vywA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 4 GLY A 104
GLU A 133
ASP A 174
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
 0.47A 3mb5A-3vywA:
11.5		 3mb5A-3vywA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 GLY A 104
GLU A 133
ASP A 174
ALA A 175
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.8A)
 0.63A 3nmuA-3vywA:
undetectable
3nmuF-3vywA:
6.8		 3nmuA-3vywA:
21.99
3nmuF-3vywA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 GLY A 104
GLU A 133
ASP A 174
ALA A 175
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.8A)
 0.92A 3nvkF-3vywA:
undetectable
3nvkJ-3vywA:
10.1		 3nvkF-3vywA:
22.16
3nvkJ-3vywA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 GLY A 104
GLY A 106
LYS A 134
ASP A 174
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
 0.82A 3p97C-3vywA:
4.7		 3p97C-3vywA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 GLY A 104
ASN A 110
ASP A 174
PHE A 195
ASN A 200
 SAM  A 501 (-3.6A)
SAM  A 501 (-3.6A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.2A)
 0.56A 3ps9A-3vywA:
22.3		 3ps9A-3vywA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 6 TYR A  67
GLY A 106
GLU A 133
ASP A 193
 SAM  A 501 (-4.5A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.8A)
 0.35A 3ps9A-3vywA:
22.3		 3ps9A-3vywA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 5 SER A 226
GLY A 104
GLU A 135
GLU A 133
 None
SAM  A 501 (-3.6A)
None
SAM  A 501 (-2.3A)
 1.19A 3raeB-3vywA:
undetectable
3raeD-3vywA:
undetectable		 3raeB-3vywA:
21.00
3raeD-3vywA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 GLY A 104
GLY A 106
ASN A 110
LYS A 134
ASP A 174
 SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
 0.67A 3sglA-3vywA:
20.2		 3sglA-3vywA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 LEU A 203
GLY A 173
LEU A 172
GLU A 133
ASP A 102
 SAM  A 501 (-4.6A)
None
None
SAM  A 501 (-2.3A)
SAM  A 501 ( 4.9A)
 1.04A 3tbgA-3vywA:
undetectable		 3tbgA-3vywA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 LEU A 203
GLY A 173
LEU A 172
GLU A 133
ASP A 102
 SAM  A 501 (-4.6A)
None
None
SAM  A 501 (-2.3A)
SAM  A 501 ( 4.9A)
 1.05A 3tbgC-3vywA:
undetectable		 3tbgC-3vywA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 LEU A 203
GLY A 173
LEU A 172
GLU A 133
ASP A 102
 SAM  A 501 (-4.6A)
None
None
SAM  A 501 (-2.3A)
SAM  A 501 ( 4.9A)
 1.02A 3tbgD-3vywA:
undetectable		 3tbgD-3vywA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 5 LEU A 154
PRO A 159
VAL A 158
ASP A 102
 None
None
None
SAM  A 501 ( 4.9A)
 1.11A 3ufnA-3vywA:
undetectable
3ufnB-3vywA:
undetectable		 3ufnA-3vywA:
17.80
3ufnB-3vywA:
17.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VYW_A_SAMA501_0
(MNMC2)		 3vyw MNMC2
(Aquifex
aeolicus) 		6 / 12 TYR A  63
GLY A 104
LEU A 137
ALA A 175
PHE A 195
LEU A 203
 None
SAM  A 501 (-3.6A)
None
SAM  A 501 (-3.8A)
SAM  A 501 (-3.7A)
SAM  A 501 (-4.6A)
 1.42A 3vywA-3vywA:
54.1		 3vywA-3vywA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VYW_A_SAMA501_0
(MNMC2)		 3vyw MNMC2
(Aquifex
aeolicus) 		12 / 12 TYR A  63
TYR A  67
GLY A 104
GLY A 106
LEU A 107
TYR A 109
ASN A 110
LYS A 134
GLU A 135
ALA A 175
PHE A 195
LEU A 203
 None
SAM  A 501 (-4.5A)
SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.3A)
SAM  A 501 (-4.6A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.4A)
None
SAM  A 501 (-3.8A)
SAM  A 501 (-3.7A)
SAM  A 501 (-4.6A)
 0.00A 3vywA-3vywA:
54.1		 3vywA-3vywA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VYW_A_SAMA501_1
(MNMC2)		 3vyw MNMC2
(Aquifex
aeolicus) 		6 / 6 HIS A  68
GLU A 133
ASP A 174
ASP A 193
ASN A 200
GLU A 202
 SAM  A 501 (-4.2A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.2A)
SAM  A 501 (-4.2A)
 0.00A 3vywA-3vywA:
54.1		 3vywA-3vywA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VYW_B_SAMB401_0
(MNMC2)		 3vyw MNMC2
(Aquifex
aeolicus) 		6 / 12 GLY A 104
LEU A 137
ALA A 175
PHE A 195
ASN A 200
LEU A 203
 SAM  A 501 (-3.6A)
None
SAM  A 501 (-3.8A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.2A)
SAM  A 501 (-4.6A)
 1.40A 3vywB-3vywA:
49.9		 3vywB-3vywA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VYW_B_SAMB401_0
(MNMC2)		 3vyw MNMC2
(Aquifex
aeolicus) 		12 / 12 TYR A  67
HIS A  68
GLY A 104
GLY A 106
LEU A 107
TYR A 109
ASN A 110
LYS A 134
ALA A 175
PHE A 195
ASN A 200
LEU A 203
 SAM  A 501 (-4.5A)
SAM  A 501 (-4.2A)
SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.3A)
SAM  A 501 (-4.6A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.2A)
SAM  A 501 (-4.6A)
 0.39A 3vywB-3vywA:
49.9		 3vywB-3vywA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VYW_B_SAMB401_1
(MNMC2)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 4 GLU A 133
ASP A 174
ASP A 193
GLU A 202
 SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-4.2A)
 0.38A 3vywB-3vywA:
49.9		 3vywB-3vywA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VYW_C_SAMC401_0
(MNMC2)		 3vyw MNMC2
(Aquifex
aeolicus) 		12 / 12 TYR A  63
TYR A  67
HIS A  68
GLY A 104
LEU A 107
GLY A 108
TYR A 109
ASN A 110
LYS A 134
ALA A 175
PHE A 195
LEU A 203
 None
SAM  A 501 (-4.5A)
SAM  A 501 (-4.2A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.3A)
SAM  A 501 (-4.1A)
SAM  A 501 (-4.6A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.7A)
SAM  A 501 (-4.6A)
 0.41A 3vywC-3vywA:
50.3		 3vywC-3vywA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VYW_C_SAMC401_1
(MNMC2)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 6 GLY A 106
GLU A 133
ASP A 174
ASP A 102
 SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 ( 4.9A)
 1.02A 3vywC-3vywA:
50.3		 3vywC-3vywA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VYW_C_SAMC401_1
(MNMC2)		 3vyw MNMC2
(Aquifex
aeolicus) 		6 / 6 GLY A 106
GLU A 133
ASP A 174
ASP A 193
ASN A 200
GLU A 202
 SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.2A)
SAM  A 501 (-4.2A)
 0.28A 3vywC-3vywA:
50.3		 3vywC-3vywA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VYW_D_SAMD401_0
(MNMC2)		 3vyw MNMC2
(Aquifex
aeolicus) 		6 / 12 TYR A  63
GLY A 104
LEU A 137
ALA A 175
PHE A 195
LEU A 203
 None
SAM  A 501 (-3.6A)
None
SAM  A 501 (-3.8A)
SAM  A 501 (-3.7A)
SAM  A 501 (-4.6A)
 1.49A 3vywD-3vywA:
50.6		 3vywD-3vywA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VYW_D_SAMD401_0
(MNMC2)		 3vyw MNMC2
(Aquifex
aeolicus) 		12 / 12 TYR A  63
TYR A  67
HIS A  68
GLY A 104
GLY A 106
LEU A 107
TYR A 109
ASN A 110
LYS A 134
ALA A 175
PHE A 195
LEU A 203
 None
SAM  A 501 (-4.5A)
SAM  A 501 (-4.2A)
SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.3A)
SAM  A 501 (-4.6A)
SAM  A 501 (-3.6A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.7A)
SAM  A 501 (-4.6A)
 0.33A 3vywD-3vywA:
50.6		 3vywD-3vywA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VYW_D_SAMD401_1
(MNMC2)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 5 GLU A 133
ASP A 174
ASP A 193
ASN A 200
GLU A 202
 SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.2A)
SAM  A 501 (-4.2A)
 0.22A 3vywD-3vywA:
50.6		 3vywD-3vywA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VYW_D_SAMD401_1
(MNMC2)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 5 GLU A 135
ASP A 174
ASN A 200
GLU A 202
 None
SAM  A 501 (-3.4A)
SAM  A 501 (-3.2A)
SAM  A 501 (-4.2A)
 1.02A 3vywD-3vywA:
50.6		 3vywD-3vywA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 GLY A 104
GLY A 106
LYS A 134
ASP A 174
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
 0.90A 4ctkA-3vywA:
6.5		 4ctkA-3vywA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 6 LYS A 213
ILE A 216
VAL A 190
LEU A 101
 None
 1.12A 4em2A-3vywA:
undetectable		 4em2A-3vywA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 7 VAL A  97
ILE A  98
LEU A 154
LEU A 115
 None
 0.85A 4l1wA-3vywA:
undetectable		 4l1wA-3vywA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 VAL A  83
ILE A  98
VAL A 127
LEU A 166
LEU A 118
 None
 1.17A 4m11C-3vywA:
undetectable		 4m11C-3vywA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 VAL A  83
ILE A  98
VAL A 127
LEU A 166
LEU A 118
 None
 1.17A 4m11D-3vywA:
undetectable		 4m11D-3vywA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 5 GLY A 220
ASP A 188
GLU A  90
VAL A 121
 None
 1.10A 4nkvD-3vywA:
undetectable		 4nkvD-3vywA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 GLU A  65
GLY A  64
TYR A 198
ILE A  59
HIS A  60
 None
 1.29A 4xucA-3vywA:
11.7		 4xucA-3vywA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 GLU A  65
GLY A  64
TYR A 198
ILE A  59
HIS A  60
 None
 1.29A 4xudA-3vywA:
11.6		 4xudA-3vywA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 GLY A 104
TYR A  67
TYR A 109
ALA A 175
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-4.5A)
SAM  A 501 (-4.6A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.8A)
 1.36A 4ymgB-3vywA:
10.5		 4ymgB-3vywA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 GLY A 104
GLY A 106
LYS A 134
ASP A 174
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
 0.79A 5eifC-3vywA:
4.7		 5eifC-3vywA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 7 GLY A 104
GLY A 106
GLU A 133
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.8A)
 0.39A 5ergB-3vywA:
10.7		 5ergB-3vywA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 ALA A 175
ASP A 193
GLY A 106
GLU A 133
GLU A 135
 SAM  A 501 (-3.8A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
None
 1.03A 5hfjA-3vywA:
5.2		 5hfjA-3vywA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 ASP A 174
ALA A 175
ASP A 193
GLY A 106
GLU A 133
 SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
 0.73A 5hfjA-3vywA:
5.2		 5hfjA-3vywA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 ASP A 174
ALA A 175
ASP A 193
GLY A 106
GLU A 133
 SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
 0.78A 5hfjD-3vywA:
2.1		 5hfjD-3vywA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 ASP A 174
ALA A 175
ASP A 193
GLY A 106
GLU A 133
 SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
 0.76A 5hfjE-3vywA:
5.3		 5hfjE-3vywA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 ASP A 174
ALA A 175
ASP A 193
GLY A 106
GLU A 133
 SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
 0.73A 5hfjF-3vywA:
5.4		 5hfjF-3vywA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 11 LEU A 166
ARG A 157
GLY A 108
ILE A 129
VAL A 170
 None
None
SAM  A 501 (-4.1A)
None
None
 1.32A 5hjiA-3vywA:
9.1		 5hjiA-3vywA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 5 ARG A 232
SER A 244
SER A 245
SER A 224
 None
 1.10A 5hswA-3vywA:
undetectable		 5hswA-3vywA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 5 ARG A 232
SER A 245
SER A 244
SER A 224
 None
 1.49A 5hswA-3vywA:
undetectable		 5hswA-3vywA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 TYR A  10
ALA A  38
PRO A 201
PHE A  37
ILE A 297
 None
 1.37A 5ljbA-3vywA:
undetectable		 5ljbA-3vywA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_A_STIA302_1
(DEOXYCYTIDINE KINASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 VAL A 303
TYR A 198
PRO A 201
GLU A 202
GLU A  33
 None
None
None
SAM  A 501 (-4.2A)
None
 1.46A 5mqtA-3vywA:
undetectable		 5mqtA-3vywA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 7 GLY A 104
GLU A 133
LYS A 134
ASP A 174
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
 0.58A 5mvsA-3vywA:
2.6		 5mvsA-3vywA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 8 GLY A 104
GLU A 133
LYS A 134
ASP A 174
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
 0.67A 5mvsB-3vywA:
8.5		 5mvsB-3vywA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		4 / 7 GLY A 104
GLU A 133
ASP A 193
ASN A 200
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.8A)
SAM  A 501 (-3.2A)
 0.72A 5n5dB-3vywA:
11.9		 5n5dB-3vywA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 GLY A 104
GLY A 106
LYS A 134
ASP A 174
ASP A 193
 SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
 0.80A 5wz2A-3vywA:
5.7		 5wz2A-3vywA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 10 GLY A 104
GLU A 133
LYS A 134
ASP A 174
ALA A 175
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
 0.84A 5x6yB-3vywA:
2.4		 5x6yB-3vywA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 10 GLY A 104
LYS A 134
ASP A 174
ALA A 175
LEU A 203
 SAM  A 501 (-3.6A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-4.6A)
 0.98A 5x6yB-3vywA:
2.4		 5x6yB-3vywA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 11 GLU A 133
LYS A 134
ASP A 174
ALA A 175
LEU A 203
 SAM  A 501 (-2.3A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-4.6A)
 0.87A 5x6yC-3vywA:
6.0		 5x6yC-3vywA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 11 GLY A 104
GLU A 133
ASP A 174
ALA A 175
LEU A 203
 SAM  A 501 (-3.6A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.4A)
SAM  A 501 (-3.8A)
SAM  A 501 (-4.6A)
 0.81A 5x6yC-3vywA:
6.0		 5x6yC-3vywA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 9 TYR A  14
PHE A  34
TYR A  10
ALA A  38
LEU A 301
 None
 1.32A 6ay6A-3vywA:
undetectable		 6ay6A-3vywA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3vyw MNMC2
(Aquifex
aeolicus) 		5 / 12 ASP A 102
GLY A 104
GLY A 106
LYS A 134
ASP A 174
 SAM  A 501 ( 4.9A)
SAM  A 501 (-3.6A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.4A)
SAM  A 501 (-3.4A)
 0.78A 6nj9K-3vywA:
4.7		 6nj9K-3vywA:
23.72