SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vzb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		5 / 9 LEU A  69
VAL A  87
GLY A  90
ALA A  60
LEU A  20
 None
 1.19A 1e7bA-3vzbA:
undetectable		 1e7bA-3vzbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		5 / 12 ALA A  30
GLY A  80
GLY A 111
GLY A  26
LEU A 116
 None
None
SO4  A 402 (-3.3A)
SO4  A 402 (-3.3A)
None
 0.88A 1eizA-3vzbA:
undetectable		 1eizA-3vzbA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		5 / 12 ALA A  30
GLY A  80
GLY A 111
GLY A  26
LEU A 116
 None
None
SO4  A 402 (-3.3A)
SO4  A 402 (-3.3A)
None
 0.85A 1ej0A-3vzbA:
undetectable		 1ej0A-3vzbA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		5 / 11 VAL A  64
ARG A  94
LEU A  75
ALA A 100
LEU A  91
 None
 1.08A 1eqgB-3vzbA:
undetectable		 1eqgB-3vzbA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		4 / 7 HIS A 156
LEU A 153
SER A 154
ASP A 235
 None
 1.29A 1ismB-3vzbA:
undetectable		 1ismB-3vzbA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		3 / 3 ASN A  22
ALA A 110
ASN A 114
 None
 0.79A 1n4fA-3vzbA:
undetectable		 1n4fA-3vzbA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		5 / 12 VAL A  19
PHE A  34
VAL A  38
LEU A  42
THR A 139
 None
 1.19A 2jn3A-3vzbA:
undetectable		 2jn3A-3vzbA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		4 / 6 LEU A 105
MET A  84
LEU A 116
MET A 361
 None
None
None
EDO  A 403 (-4.7A)
 1.04A 2kuhA-3vzbA:
undetectable		 2kuhA-3vzbA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		3 / 3 PHE A 257
VAL A 260
TRP A 171
 None
None
EDO  A 406 (-4.7A)
 0.90A 2vx9A-3vzbA:
undetectable		 2vx9A-3vzbA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		4 / 5 VAL A 260
TYR A 289
VAL A 252
ASP A 254
 None
 1.06A 2x45A-3vzbA:
undetectable		 2x45A-3vzbA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		5 / 12 GLN A 128
GLY A  80
ASP A  81
ALA A 115
SER A 168
 None
None
None
SQS  A 401 ( 4.8A)
SQS  A 401 (-3.1A)
 1.19A 3d91B-3vzbA:
undetectable		 3d91B-3vzbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		5 / 12 ALA A  30
GLY A  80
GLY A 111
GLY A  26
LEU A 116
 None
None
SO4  A 402 (-3.3A)
SO4  A 402 (-3.3A)
None
 0.87A 3douA-3vzbA:
undetectable		 3douA-3vzbA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		4 / 6 GLY A 113
GLU A 189
GLY A 269
MET A 272
 SQS  A 401 ( 4.2A)
None
None
SQS  A 401 (-3.5A)
 0.96A 3e9rA-3vzbA:
undetectable		 3e9rA-3vzbA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		4 / 6 GLY A 113
GLU A 189
GLY A 269
MET A 272
 SQS  A 401 ( 4.2A)
None
None
SQS  A 401 (-3.5A)
 0.96A 3e9rC-3vzbA:
undetectable		 3e9rC-3vzbA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		5 / 12 GLY A 113
LEU A 268
LEU A  83
SER A 168
GLU A 343
 SQS  A 401 ( 4.2A)
SQS  A 401 (-4.4A)
None
SQS  A 401 (-3.1A)
None
 1.03A 3g2oA-3vzbA:
undetectable		 3g2oA-3vzbA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 101
PHE A 359
VAL A  64
LEU A 105
LEU A  83
 None
 0.98A 3ozuA-3vzbA:
undetectable		 3ozuA-3vzbA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		5 / 12 VAL A  64
ARG A  94
LEU A  75
ALA A 100
LEU A  91
 None
 0.97A 3rr3A-3vzbA:
undetectable		 3rr3A-3vzbA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		5 / 12 VAL A  64
ARG A  94
LEU A  75
ALA A 100
LEU A  91
 None
 0.97A 3rr3B-3vzbA:
undetectable		 3rr3B-3vzbA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		5 / 12 ASP A 341
LEU A 163
LEU A 155
GLY A 352
MET A 285
 None
 1.40A 4pfjB-3vzbA:
4.1		 4pfjB-3vzbA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		5 / 10 VAL A  64
ARG A  94
LEU A  75
ALA A 100
LEU A  91
 None
 1.04A 4ph9B-3vzbA:
undetectable		 4ph9B-3vzbA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		4 / 6 LEU A 259
PHE A 303
THR A 196
VAL A 177
 None
None
SQS  A 401 ( 4.3A)
SQS  A 401 ( 4.5A)
 1.09A 4udaA-3vzbA:
undetectable		 4udaA-3vzbA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		4 / 5 LEU A 116
ASP A  81
TYR A 123
LEU A 120
 None
None
EDO  A 408 (-4.8A)
EDO  A 403 (-4.5A)
 1.27A 4wozF-3vzbA:
undetectable
4wozH-3vzbA:
undetectable		 4wozF-3vzbA:
21.64
4wozH-3vzbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		5 / 12 SER A 270
CYH A 138
LEU A 140
LEU A 134
ALA A 117
 None
EDO  A 403 (-4.1A)
None
None
None
 1.21A 4x1kA-3vzbA:
undetectable
4x1kB-3vzbA:
undetectable		 4x1kA-3vzbA:
22.03
4x1kB-3vzbA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		4 / 6 LEU A 134
ASN A 114
PRO A 109
ARG A 144
 None
 1.44A 4yv5B-3vzbA:
undetectable		 4yv5B-3vzbA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		4 / 6 LEU A 134
ASN A 114
PRO A 109
ARG A 144
 None
 1.42A 4yv5A-3vzbA:
undetectable		 4yv5A-3vzbA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		4 / 6 GLY A 195
THR A 196
SER A 181
VAL A 177
 None
SQS  A 401 ( 4.3A)
None
SQS  A 401 ( 4.5A)
 0.87A 5ewuA-3vzbA:
undetectable		 5ewuA-3vzbA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		5 / 12 LEU A 263
GLY A 269
ALA A 115
SER A 119
LEU A 116
 None
None
SQS  A 401 ( 4.8A)
None
None
 1.05A 5ikrA-3vzbA:
undetectable		 5ikrA-3vzbA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		4 / 6 HIS A 237
VAL A 234
ARG A 162
HIS A 156
 EDO  A 404 (-3.6A)
None
None
None
 1.46A 5kkzA-3vzbA:
undetectable
5kkzG-3vzbA:
undetectable		 5kkzA-3vzbA:
22.01
5kkzG-3vzbA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		5 / 10 GLY A 172
LEU A 259
THR A 205
ALA A 292
LEU A 299
 EDO  A 406 (-3.4A)
None
None
None
None
 1.00A 6czmA-3vzbA:
undetectable
6czmC-3vzbA:
undetectable		 6czmA-3vzbA:
23.62
6czmC-3vzbA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		4 / 5 TYR A 123
VAL A 340
PHE A 273
GLY A 278
 EDO  A 408 (-4.8A)
None
None
EDO  A 408 ( 3.9A)
 1.20A 6hd4A-3vzbA:
undetectable		 6hd4A-3vzbA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3vzb SPHINGOSINE KINASE 1
(Homo
sapiens) 		4 / 7 GLY A  82
HIS A  85
VAL A  88
SER A 168
 None
None
None
SQS  A 401 (-3.1A)
 0.94A 6hu9S-3vzbA:
undetectable
6hu9q-3vzbA:
undetectable		 6hu9S-3vzbA:
12.36
6hu9q-3vzbA:
14.44