SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vzi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE
(Xanthomonas
oryzae) 		4 / 6 ASP A 196
GLY A 197
THR A 199
PRO A 200
 None
 0.82A 1n4fA-3vziA:
undetectable		 1n4fA-3vziA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_A_CHCA202_1
(BILE ACID RECEPTOR)		 3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE
(Xanthomonas
oryzae) 		5 / 12 PHE A  16
SER A  27
PHE A  64
ILE A  62
TYR A 114
 None
 1.38A 1osvA-3vziA:
0.0		 1osvA-3vziA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE
(Xanthomonas
oryzae) 		5 / 12 PHE A  16
SER A  27
PHE A  64
ILE A  62
TYR A 114
 None
 1.31A 1osvB-3vziA:
undetectable		 1osvB-3vziA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE
(Xanthomonas
oryzae) 		5 / 12 PHE A  16
SER A  27
PHE A  64
ILE A  62
TYR A 114
 None
 1.35A 1ot7A-3vziA:
undetectable		 1ot7A-3vziA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE
(Xanthomonas
oryzae) 		4 / 8 ALA A  14
PHE A  16
THR A 156
ALA A  35
 None
 0.83A 3hrdA-3vziA:
undetectable
3hrdB-3vziA:
undetectable		 3hrdA-3vziA:
19.16
3hrdB-3vziA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE
(Xanthomonas
oryzae) 		5 / 12 PHE A 120
THR A 123
ALA A 143
ILE A  39
ALA A  36
 None
 1.15A 3nxuB-3vziA:
undetectable		 3nxuB-3vziA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE
(Xanthomonas
oryzae) 		3 / 3 PHE A 159
VAL A 108
GLU A  65
 None
 0.71A 4fvqA-3vziA:
undetectable		 4fvqA-3vziA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE
(Xanthomonas
oryzae) 		3 / 3 SER A   2
ASP A 168
ASP A 170
 None
 0.91A 4mwzA-3vziA:
undetectable		 4mwzA-3vziA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE
(Xanthomonas
oryzae) 		3 / 3 ALA A 118
TRP A  51
VAL A  52
 None
 0.30A 4w9nC-3vziA:
undetectable		 4w9nC-3vziA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE
(Xanthomonas
oryzae) 		3 / 3 ARG A 206
ASP A 184
ARG A 204
 None
 0.70A 4wq4B-3vziA:
undetectable		 4wq4B-3vziA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE
(Xanthomonas
oryzae) 		6 / 12 LEU A   7
GLY A  38
ALA A  36
ILE A  56
VAL A 214
ILE A 116
 None
 1.42A 5e5kA-3vziA:
undetectable		 5e5kA-3vziA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE
(Xanthomonas
oryzae) 		3 / 3 ARG A 141
HIS A  44
ARG A 142
 None
 0.90A 5iaoC-3vziA:
undetectable		 5iaoC-3vziA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE
(Xanthomonas
oryzae) 		3 / 3 ARG A 141
HIS A  44
ARG A 142
 None
 0.93A 5iaoF-3vziA:
undetectable		 5iaoF-3vziA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE
(Xanthomonas
oryzae) 		5 / 12 ILE A 115
LEU A 211
GLY A 210
ALA A 213
VAL A 214
 None
 1.08A 5x66F-3vziA:
undetectable		 5x66F-3vziA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE
(Xanthomonas
oryzae) 		3 / 3 ARG A  25
PHE A 159
ARG A  69
 None
 1.16A 5y9yA-3vziA:
undetectable		 5y9yA-3vziA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE
(Xanthomonas
oryzae) 		3 / 3 ARG A 104
PHE A 159
ARG A  69
 None
 0.84A 5y9yA-3vziA:
undetectable		 5y9yA-3vziA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE
(Xanthomonas
oryzae) 		3 / 3 TYR A 114
ALA A  35
LEU A 154
 None
 0.75A 6d9kF-3vziA:
undetectable		 6d9kF-3vziA:
16.42